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Naji, M. |
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Motta, Antonella |
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Aletan, Dirar |
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Mohamed, Tarek |
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Ertürk, Emre |
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Taccardi, Nicola |
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Kononenko, Denys |
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Petrov, R. H. | Madrid |
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Alshaaer, Mazen | Brussels |
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Bih, L. |
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Casati, R. |
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Muller, Hermance |
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Kočí, Jan | Prague |
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Šuljagić, Marija |
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Kalteremidou, Kalliopi-Artemi | Brussels |
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Azam, Siraj |
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Ospanova, Alyiya |
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Blanpain, Bart |
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Ali, M. A. |
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Popa, V. |
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Rančić, M. |
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Ollier, Nadège |
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Azevedo, Nuno Monteiro |
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Landes, Michael |
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Rignanese, Gian-Marco |
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Van Erps, Jurgen
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (21/21 displayed)
- 2023VCSEL wavelength tunability using controlled mechanical strain
- 2021Increasing the Microfabrication Performance of Synthetic Hydrogel Precursors through Molecular Designcitations
- 20203D direct laser writing of microstructured optical fiber tapers on single-mode fibers for mode-field conversioncitations
- 2018Ultrathin Poly-DL-Lactic Membranes for Corneal Endothelial Transplantation
- 2018Localized optical- quality doping of graphene on silicon waveguides through a TFSA- containing polymer matrixcitations
- 2016Replication of self-centering optical fiber alignment structures using hot embossingcitations
- 2016Hot-embossing replication of self-centering optical fiber alignment structures prototyped by deep proton writingcitations
- 2016Deep proton writing with 12 MeV protons for rapid prototyping of microstructures in polymethylmethacrylatecitations
- 2016Optofluidic multi-measurement system for the online monitoring of lubricant oilcitations
- 2016Design and prototyping of self-centering optical single-mode fiber alignment structurescitations
- 2015Mould insert fabrication of a single-mode fibre connector alignment structure optimized by justified partial metallizationcitations
- 2013Low-coherence interferometry with polynomial interpolation on Compute Unified Device Architectur-enabled graphics processing units
- 2013Gloss, hydrophobicity and surface texture of papers with organic nanoparticle coatings
- 2013B-Calm: An open-source multi-GPU-based 3D-FDTD with multi-pole dispersion for plasmonics
- 2010Populating multi-fiber fiberoptic connectors using an interferometric measurement of fiber tip position and facet quality
- 2010Design and fabrication of embedded micro-mirror inserts for out-of-plane coupling in PCB-level optical interconnects
- 2008Hot embossing of microoptical components prototyped by deep proton writing
- 2008Embedded Micro-Mirror inserts for optical printed circuit boards
- 2008Deep Proton Writing: A tool for rapid prototyping of polymer micro-opto-mechanical modules
- 2007Deep Proton Writing: A tool for rapid prototyping polymer micro-opto-mechanical modules
- 2006Laser Ablation of Parallel Optical Interconnect Waveguides
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article
Increasing the Microfabrication Performance of Synthetic Hydrogel Precursors through Molecular Design
Abstract
Implementation of hydrogel precursors in two-photon polymerization (2PP) technology provides promising opportunities in the tissue engineering field thanks to their soft characteristics and similarity to extracellular matrix. Most of the hydrogels, however, are prone to post-fabrication deformations, leading to a mismatch between the computer-aided design and the printed structure. In the present work, we have developed novel synthetic hydrogel precursors to overcome the limitations associated with 2PP processing of conventional hydrogel precursors such as post-processing deformations and a narrow processing window. The precursors are based on a poly(ethylene glycol) backbone containing urethane linkers and are, on average, functionalized with six acrylate terminal groups (three on each terminal group). As a benchmark material, we exploited a precursor with an identical backbone and urethane linkers, albeit functionalized with two acrylate groups, that were reported as state-of-the-art. An in-depth characterization of the hexafunctional precursors revealed a reduced swelling ratio (<0.7) and higher stiffness (>36 MPa Young's modulus) compared to their difunctional analogs. The superior physical properties of the newly developed hydrogels lead to 2PP-based fabrication of stable microstructures with excellent shape fidelity at laser scanning speeds up to at least 90 mm s-1, in contrast with the distorted structures of conventional difunctional precursors. The hydrogel films and microscaffolds revealed a good cell interactivity after functionalization of their surface with a gelatin methacrylamide-based coating. The proposed synthesis strategy provides a one-pot and scalable synthesis of hydrogel building blocks that can overcome the current limitations associated with 2PP fabrication of hydrogel microstructures