| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Klaushofer, Klaus
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (12/12 displayed)
- 2017Pyridinoline collagen cross-link content at actively forming trabecular surfaces is associated with fragility fracture incidence independent of BMD and the clinical diagnosis.
- 2017IFITM5 (BRIL) p.S40L mutation causing atypical type VI OI results in unique bone material phenotype impacting both endochondral ossification and chondrocyte development.
- 2017Fkbp10 Deletion in Osteoblasts Leads to Qualitative Defects in Bonecitations
- 2016Aging Versus Postmenopausal Osteoporosis: Bone Composition and Maturation Kinetics at Actively-Forming Trabecular Surfaces of Female Subjects Aged 1 to 84 Yearscitations
- 2016Evidence for a Role for Nanoporosity and Pyridinoline Content in Human Mild Osteogenesis Imperfectacitations
- 2015Unique micro- and nano-scale mineralization pattern of human osteogenesis imperfecta type VI bonecitations
- 2015Fragility of Bone Material Controlled by Internal Interfacescitations
- 2014Mapping dynamical mechanical properties of osteonal bone by scanning acoustic microscopy in time-of-flight modecitations
- 2014Changes in the Degree of Mineralization with Osteoporosis and its Treatmentcitations
- 2014Relationship between the v(2)PO(4)/amide III ratio assessed by Raman spectroscopy and the calcium content measured by quantitative backscattered electron microscopy in healthy human osteonal bonecitations
- 2014Mineral particle size in children with osteogenesis imperfecta type I is not increased independently of specific collagen mutationscitations
- 2012Microcracks and Osteoclast Resorption Activity In Vitrocitations
Places of action
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article
Mapping dynamical mechanical properties of osteonal bone by scanning acoustic microscopy in time-of-flight mode
Abstract
<p>An important determinant of mechanical properties of bone is Young's modulus and its variation in individual osteons of cortical bone tissue. Its mechanical behavior also depends on deformation rate owing to its visco-or poroelastic properties. We developed a method to measure dynamical mechanical properties of bulk bone tissue at osteonal level based on scanning acoustic microscopy (SAM) using time-of-flight (TOF) measurements in combination with quantitative backscattered electron imaging (qBEI). SAM-TOF yields local sound velocities and qBEI corresponding material densities together providing elastic properties. Osteons (n=55) were measured in three human femoral diaphyseal ground bone sections (∼30 μm in thickness). In addition, subchondral bone and mineralized articular cartilage were investigated. The mean mineral contents, the mean sound velocities, and the mean elastic modulus of the osteons ranged from 20 to 26 wt%, from 3,819 to 5,260 m/s, and from 21 to 44 GPa, respectively. There was a strong positive correlation between material density and sound velocity (Pearson's r=0.701; p<0.0001) of the osteons. Sound velocities between cartilage and bone was similar, though material density was higher in cartilage (+4.46%, p<0.0001). These results demonstrate the power of SAM-TOF to estimate dynamic mechanical properties of the bone materials at the osteonal level.</p>