| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Roschger, Andreas
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (13/13 displayed)
- 2024Postembedding Iodine Staining for Contrast‐Enhanced 3D Imaging of Bone Tissue Using Focused Ion Beam‐Scanning Electron Microscopy
- 2024Twisted-plywood-like tissue formation in vitro. Does curvature do the twist?citations
- 2023Twisted plywood-like tissue formation in vitro. Does curvature do the twist?citations
- 20213D Interrelationship between Osteocyte Network and Forming Mineral during Human Bone Remodelingcitations
- 2020The mechanoresponse of bone is closely related to the osteocyte lacunocanalicular network architecturecitations
- 2020Heterogeneity of the osteocyte lacuno-canalicular network architecture and material characteristics across different tissue types in healing bonecitations
- 2019Mechanical properties of stingray tesserae: High-resolution correlative analysis of mineral density and indentation moduli in tessellated cartilagecitations
- 2019Cortical bone properties in the Brtl/+ mouse model of Osteogenesis imperfecta as evidenced by acoustic transmission microscopycitations
- 2017IFITM5 (BRIL) p.S40L mutation causing atypical type VI OI results in unique bone material phenotype impacting both endochondral ossification and chondrocyte development.
- 2016The nanostructure of murine alveolar bone and its changes due to type 2 diabetescitations
- 2015Unique micro- and nano-scale mineralization pattern of human osteogenesis imperfecta type VI bonecitations
- 2014Mapping dynamical mechanical properties of osteonal bone by scanning acoustic microscopy in time-of-flight modecitations
- 2014Relationship between the v(2)PO(4)/amide III ratio assessed by Raman spectroscopy and the calcium content measured by quantitative backscattered electron microscopy in healthy human osteonal bonecitations
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article
Mapping dynamical mechanical properties of osteonal bone by scanning acoustic microscopy in time-of-flight mode
Abstract
<p>An important determinant of mechanical properties of bone is Young's modulus and its variation in individual osteons of cortical bone tissue. Its mechanical behavior also depends on deformation rate owing to its visco-or poroelastic properties. We developed a method to measure dynamical mechanical properties of bulk bone tissue at osteonal level based on scanning acoustic microscopy (SAM) using time-of-flight (TOF) measurements in combination with quantitative backscattered electron imaging (qBEI). SAM-TOF yields local sound velocities and qBEI corresponding material densities together providing elastic properties. Osteons (n=55) were measured in three human femoral diaphyseal ground bone sections (∼30 μm in thickness). In addition, subchondral bone and mineralized articular cartilage were investigated. The mean mineral contents, the mean sound velocities, and the mean elastic modulus of the osteons ranged from 20 to 26 wt%, from 3,819 to 5,260 m/s, and from 21 to 44 GPa, respectively. There was a strong positive correlation between material density and sound velocity (Pearson's r=0.701; p<0.0001) of the osteons. Sound velocities between cartilage and bone was similar, though material density was higher in cartilage (+4.46%, p<0.0001). These results demonstrate the power of SAM-TOF to estimate dynamic mechanical properties of the bone materials at the osteonal level.</p>