| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Araujo, An
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (6/6 displayed)
- 2017Synthesis of distinctly thiol-capped CdTe quantum dots under microwave heating: multivariate optimization and characterizationcitations
- 2009Modeling, Structural, and Spectroscopic Studies of Lanthanide-Organic Frameworkscitations
- 2006Extraction and recovery of chromium from electroplating sludgecitations
- 2004Sequential injection analysis of lead using time-based colorimetric detection and preconcentration on an anionic-exchange resincitations
- 2004Simultaneous determination of pH, chloride and nickel in electroplating baths using sequential injection analysiscitations
- 2001Sequential injection analysis of captopril based on colorimetric and potentiometric detectioncitations
Places of action
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article
Sequential injection analysis of captopril based on colorimetric and potentiometric detection
Abstract
The development of an analytical procedure based on the sequential injection analysis (SIA) concept for the analytical control of captopril in pharmaceutical formulations is described. The robustness of the proposed system is established by accuracy assessment that consists in yielding a versatile manifold for the carryout of two quasi-independent analytical determinations. One of the captopril determination procedures is based on the colorimetric measurement of the captopril-palladium complex in acid media at the 400 nm. No interference from other compounds usually contained in the samples was found, even when its concentration was 25 times higher than that of the analyte. The other procedure involves the potentiometric titration of captopril with a 10(-3) mol/l Ag(I) solution used as titrant and the application of the Gran's method for ascertaining the equivalence point. Accuracy of the proposed approach was attained by developing an in-line calibration procedure for the assessment of the electrode slope and performing titration in four different titrant/analyte mixtures. Precision of the developed procedures was better than 1.3%, being similar to that of the reference chromatographic method. The results attained were statistically similar to those given by the reference method and, thus, the accuracy assessment concept may be used for the determination of failures of the analytical procedure when performing large-scale analysis.