Materials Map

Discover the materials research landscape. Find experts, partners, networks.

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The Materials Map is an open tool for improving networking and interdisciplinary exchange within materials research. It enables cross-database search for cooperation and network partners and discovering of the research landscape.

The dashboard provides detailed information about the selected scientist, e.g. publications. The dashboard can be filtered and shows the relationship to co-authors in different diagrams. In addition, a link is provided to find contact information.

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Materials Map under construction

The Materials Map is still under development. In its current state, it is only based on one single data source and, thus, incomplete and contains duplicates. We are working on incorporating new open data sources like ORCID to improve the quality and the timeliness of our data. We will update Materials Map as soon as possible and kindly ask for your patience.

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Schneider, M.

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in Cooperation with on an Cooperation-Score of 37%

Topics

Publications (61/61 displayed)

  • 2024High-Temperature Corrosion of High- and Medium-Entropy Alloys CrMnFeCoNi and CrCoNi Exposed to a Multi-Oxidant Atmosphere H2O–O2–SO22citations
  • 2022A Round Robin Test To Investigate The Printing Quality Of PBF-LB/M Processed AlSi10Mgcitations
  • 2022A space-time upscaling technique for modeling high-cycle fatigue-damage of short-fiber reinforced composites20citations
  • 2022Thermo-mechanical properties prediction of Ni-reinforced Al$_2$O$_3$ composites using micro-mechanics based representative volume elementscitations
  • 2022Thermo-mechanical properties prediction of Ni-reinforced Al2O3 composites using micro-mechanics based representative volume elements12citations
  • 2022Reproducibility and Scattering in Additive Manufacturing: Results from a Round Robin on PBF-LB/M AlSi10Mg Alloy3citations
  • 2022Influence of machining on the surface integrity of high- and medium-entropy alloys21citations
  • 2022Inner relaxations in equiatomic single-phase high-entropy Cantoralloy14citations
  • 2021Identification of Stability Constraints in the Particle Engineering of an Inhaled Monoclonal Antibody Dried Powder.13citations
  • 2021Welding of high-entropy alloys and compositionally complex alloys - an overview36citations
  • 2020High-Temperature Oxidation in Dry and Humid Atmospheres of the Equiatomic CrMnFeCoNi and CrCoNi High- and Medium-Entropy Alloys49citations
  • 2020High temperature sintering and its effect on dimensional and geometrical precision and on microstructure of low alloyed steels4citations
  • 2019Efficient multiscale methods for viscoelasticity and fatigue of short fiber-reinforced polymers7citations
  • 2019Development of additive manufactured, highly integrative tensioning templates for CFRP components,Additiv gefertigte Spannmittel für CFK-BauteileUntersuchung der Eigenschaften und prototypische Umsetzungcitations
  • 2018Seamless tool fabrication for Roll-to-Roll microreplication18citations
  • 2018Modelling the microstructure and computing effective elastic properties of sand core materials31citations
  • 2018Fiber orientation interpolation for the multiscale analysis of short fiber reinforced composite parts70citations
  • 2017Introducing high strength and ductility twinning induced plasticity (TWIP) steels for European automotive applications through advanced material modeling (TWIP4EU)citations
  • 2016Weak side of strong topological insulatorscitations
  • 20163D high throughput screening and profiling of embryoid bodies in thermoformed microwell plates69citations
  • 2016Pilot-scale removal and recovery of dissolved phosphate from secondary wastewater effluents with reusable ZnFeZr adsorbent @ Fe<sub>3</sub>O<sub>4</sub>/SiO<sub>2</sub> particles with magnetic harvesting.157citations
  • 2015Mould insert fabrication of a single-mode fibre connector alignment structure optimized by justified partial metallization11citations
  • 2015Mould insert fabrication of a single-mode fibre connector alignment structure optimized by justified partial metallization11citations
  • 2015Programmable and self-demolding microstructured molds fabricated from shape-memory polymers15citations
  • 2015Determination of state of charge-dependent asymmetric Butler-Volmer kinetics for LixCoO2 electrode using GITT measurements75citations
  • 2014D2 enertrode: Production technologies and component integration of nanostructured carbon electrodes for energy technology-functionalized carbon materials for efficient electrical energy supplycitations
  • 2014Electrochemical corrosion of silicon carbide ceramics in H2SO461citations
  • 2014Hot embossing and thermoforming of biodegradable three-dimensional wood structures23citations
  • 2014High power density LED modules with silver sintering die attach on aluminum nitride substratescitations
  • 2014Macroscopic modelling and simulations of material behaviour of modern twinning-induced plasticity steelscitations
  • 2014Deformation behaviour of TWIP-Steels: From experiments to constitutive modelling and simulationscitations
  • 2013Electrochemical corrosion of liquid phase sintered silicon carbide ceramics16citations
  • 2013Morphology of blends with cross-linked PMMA microgels and linear PMMA chains12citations
  • 2012Study of delamination induced by laser drilling of thermally sprayed TBC interfacescitations
  • 2011Study of influencing factors in micro thermoforming and micro blow moldingcitations
  • 2011Investigation of anodic dissolution of cobalt in alkaline solution ; Untersuchung der anodischen Auflösung von Cobalt in alkalischer Lösungcitations
  • 2011Thickness determination of thin anodic titanium oxide films13citations
  • 2011Influence of electric potentials on the tribological behaviour of silicon carbide29citations
  • 2010Towards the flexible and near-net-shape production of three-dimensionally curved extrusion profiles3citations
  • 2009Increase in quality and reliability of the process chain in the flexible manufacture of light space frame structures | Prozesskette zur flexiblen herstellung leichter tragwerkstrukturen steigerung der qualität und zuverlässigkeitcitations
  • 2009Investigating corrosion protection of offshore wind towers: Pt.2: Results of the site testscitations
  • 2009Micro-EIS of anodic thin oxide films on titanium for capacitor applications51citations
  • 2008The electronic structure of La 1-x Sr x MnO 3 thin films and its T c dependence as studied using angle-resolved photoemission4citations
  • 2008Consideration of nonlinear creep strain of siliceous concrete on calculation of mechanical strain under transient temperatures as a function of load historycitations
  • 2008Novel aluminum-rich Ti1- xAlxN coatings by LPCVD69citations
  • 2008Protection I: Oxide tailoring for downstream modification by chemical nanotechnology to upgrade adhesive properties and corrosion protection of aluminum alloys ; Korrosionsschutz I. Maßschneidern von Oxiden für die Nachfolgemodifikation durch chemische Nanotechnologie zur Verbesserung der adhäsiven Eigenschaften und des Korrosionsschutzes von Aluminiumlegierungencitations
  • 2008Novel aluminum-rich Ti(ind 1 - x)Al(ind x)N coatings by LPCVD69citations
  • 2008Investigation of thin oxide films on titanium for capacitor applications10citations
  • 2007Interplay between the deposition mode and microstructure in electrochemically deposited Cu thin films19citations
  • 2007Microstructure formation in electrochemically deposited Copper thin films1citations
  • 2007Modification of anodic layers on aluminium alloys ; Modifikation anodischer Schichten auf Aluminiumlegierungencitations
  • 2007Investigation of the initial stage of crevice corrosion on Al99.5 by electrochemical noise analysis ; Untersuchung des Anfangstadiums der Spaltkorrosion von Al99.5 durch elektrochemische Rauschanalysen5citations
  • 2007Preparation of epitaxial La 0.6 Ca 0.4 Mn 1- x Fe x O 3 ( x = 0, 0.2) thin films: variation of the oxygen content6citations
  • 2007Simulation of Phase Changes During Thermal Treatments of Various Metal Alloys (TP B2)citations
  • 2007Preparation of epitaxial La0.6Ca0.4Mn1-xFexO3 (x=0, 0.2) thin films: Variation of the oxygen content6citations
  • 2006Aluminium-rich Ti(1-x)Al(x)N coatings by CVDcitations
  • 2004Pulsed laser deposition of atomically flat La1-xSrxMnO3 thin films using a novel target geometrycitations
  • 2003Specific heat in the mixed state of non-magnetic borocarbides1citations
  • 2003Optimization of chemical and electrochemical parameters for the preparation of n-typeBi2Te0.7Se0.3 thin films by electrodeposition39citations
  • 2002Erratum: Specific heat and disorder in the mixed state of non-magnetic borocarbides (Europhysics Letters (2002) 58:3 (435-441))1citations
  • 2002Specific heat and disorder in the mixed state of non-magnetic borocarbides25citations

Places of action

Chart of shared publication
Karafiludis, Stephanos
2 / 8 shared
Manzoni, Anna M.
1 / 4 shared
Laplanche, G.
5 / 13 shared
Mohring, W.
1 / 1 shared
Stephan-Scherb, C.
1 / 2 shared
Hilgenberg, Kai
1 / 43 shared
Schlingmann, T.
2 / 2 shared
Bettge, Dirk
1 / 20 shared
Binder, M.
2 / 5 shared
Schmidt, J.
1 / 29 shared
Klöden, B.
2 / 14 shared
Welschinge, F.
1 / 1 shared
Magino, Nicola
1 / 6 shared
Köbler, Jonathan
1 / 9 shared
Andrä, Heiko
1 / 19 shared
Müller, R.
3 / 31 shared
Abubakar, Abba A.
2 / 5 shared
Al-Athel, K. S.
2 / 2 shared
Shahzamanian, M. M.
2 / 2 shared
Akhtar, S. S.
1 / 6 shared
Basirun, W. J.
2 / 2 shared
Shakelly, N.
2 / 2 shared
Hakeem, Abbas Saeed
2 / 14 shared
Wu, P. D.
2 / 2 shared
Arif, A. F. M.
2 / 2 shared
Akhtar, Syed Sohail
1 / 5 shared
Hilgenberg, K.
1 / 1 shared
Dreyer, M.
1 / 1 shared
Dollmeier, K.
1 / 1 shared
Bettge, D.
1 / 2 shared
Schmidt, Jonathan
1 / 4 shared
Boerner, Andreas
1 / 3 shared
Schroepfer, Dirk
1 / 12 shared
Saliwan Neumann, Romeo
1 / 10 shared
Richter, Tim
2 / 19 shared
Rhode, Michael
2 / 53 shared
Siemensmeyer, K.
1 / 3 shared
De Oliveira Guilherme Buzanich, Ana
1 / 12 shared
Yusenko, Kirill
1 / 20 shared
Reinholz, Uwe
1 / 12 shared
Abrudan, R.
1 / 3 shared
Kuzmin, A.
1 / 11 shared
Smekhova, A.
1 / 5 shared
Hdc, Smyth
1 / 1 shared
Wu, T.
1 / 14 shared
Khalaf, Ryan
1 / 1 shared
Brunaugh, Ashlee
1 / 1 shared
Ding, Li
1 / 1 shared
Manzoni, Anna Maria
1 / 13 shared
Schröpfer, Dirk
1 / 40 shared
Stephan-Scherb, Christiane
1 / 13 shared
Schulz, Wencke
1 / 5 shared
Cristofolini, I.
1 / 1 shared
Arnhold, V.
1 / 1 shared
Sicre, J.
1 / 1 shared
Toledo, D.
1 / 1 shared
Molinari, A.
1 / 16 shared
Dougan, M.
1 / 2 shared
Weber, H.
1 / 3 shared
Bonnefoy, V.
1 / 1 shared
Kruzhanov, V.
1 / 1 shared
Vervoort, P.
1 / 1 shared
Larsson, C.
1 / 3 shared
Baumgartner, F.
1 / 1 shared
Hellein, R.
1 / 1 shared
Wimbert, L.
1 / 1 shared
Welschinger, F.
1 / 2 shared
Staub, S.
1 / 3 shared
Köbler, J.
2 / 2 shared
Andrä, H.
3 / 17 shared
Gebhardt, A.
1 / 3 shared
Götz, T.
1 / 1 shared
Esch, P.
1 / 1 shared
Modler, Nils
1 / 355 shared
Vogel, C.
1 / 13 shared
Striegel, A.
1 / 1 shared
Benkel, Ch.
1 / 1 shared
Worgull, M.
4 / 8 shared
Schneider, N.
1 / 5 shared
Steeb, H.
1 / 2 shared
Volk, W.
1 / 39 shared
Lechner, P.
1 / 3 shared
Ettemeyer, F.
1 / 2 shared
Hofmann, T.
1 / 10 shared
Ospald, F.
1 / 2 shared
Erhart, A.
3 / 3 shared
Haufe, A.
3 / 3 shared
Biasutti, M.
3 / 4 shared
Hagstrom, J.
3 / 3 shared
Croizet, D.
3 / 3 shared
Stenberg, N.
3 / 4 shared
Zapara, M.
3 / 4 shared
Butz, A.
3 / 11 shared
Kampczyk, M.
2 / 2 shared
Sbierski, Björn
1 / 2 shared
Brouwer, Piet W.
1 / 8 shared
Rivron, N. C.
1 / 2 shared
Kolew, A.
5 / 5 shared
Heilig, M.
3 / 7 shared
Espinoza, S.
1 / 1 shared
Van Blitterswijk, Clemens A.
1 / 21 shared
Vrij, Erik
1 / 1 shared
Truckenmüller, Roman
1 / 14 shared
Franzreb, Matthias
1 / 5 shared
Steinmetz, H.
1 / 2 shared
Gellermann, Carsten
1 / 3 shared
Meyer, C.
1 / 6 shared
Drenkova-Tuhtan, Asya
1 / 3 shared
Mandel, Karl
1 / 13 shared
Sextl, G.
1 / 4 shared
Watté, J.
1 / 1 shared
Van Erps, Jurgen
1 / 21 shared
Besser, H.
2 / 4 shared
Barie, N.
2 / 2 shared
Wissmann, M.
1 / 4 shared
Hofmann, A.
2 / 6 shared
Guttmann, M.
2 / 8 shared
Beri, Stefano
1 / 4 shared
Pfleging, W.
2 / 11 shared
Wissmann, Markus
1 / 2 shared
Erps, J. Van
1 / 3 shared
Beri, S.
1 / 1 shared
Watte, J.
1 / 1 shared
Hölscher, H.
2 / 4 shared
Reinhard, M.
1 / 2 shared
Meier, Tobias
1 / 3 shared
Bur, J.
1 / 1 shared
Cuniberti, Gianaurelio
1 / 456 shared
Heubner, C.
1 / 1 shared
Roode-Gutzmer, Q.
1 / 1 shared
Hess, A.
1 / 1 shared
Michaelis, A.
8 / 47 shared
Bobeth, M.
1 / 7 shared
Weiser, M.
1 / 14 shared
Kaskel, S.
1 / 24 shared
Giebeler, L.
1 / 69 shared
Dörfler, S.
1 / 3 shared
Beyer, E.
1 / 58 shared
Pinkert, K.
1 / 9 shared
Eckert, Jürgen
1 / 1035 shared
Goldberg, A.
1 / 5 shared
Wabnitz, C.
1 / 1 shared
Ferse, B.
1 / 1 shared
Althues, H.
1 / 7 shared
Kremmer, K.
3 / 3 shared
Herrmann, M.
6 / 62 shared
Sempf, K.
2 / 8 shared
Sydow, U.
4 / 4 shared
Feit, K.
1 / 2 shared
Röhrig, M.
1 / 1 shared
Leuthold, J.
1 / 14 shared
Meier, T.
1 / 2 shared
Maikowske, S.
1 / 1 shared
Herbold, C.
1 / 1 shared
Leyrer, B.
1 / 2 shared
Helm, D.
2 / 15 shared
Kleebe, H.-J.
1 / 14 shared
Goerigk, G.
1 / 15 shared
Huber, K.
1 / 2 shared
Michels, R.
1 / 1 shared
Pipich, V.
1 / 7 shared
Heim, Hans-Peter
1 / 104 shared
Sauer, V.
1 / 1 shared
Girardot, J.
1 / 2 shared
Berthe, L.
1 / 12 shared
Guipont, Vincent
1 / 29 shared
Guinard, Caroline
1 / 2 shared
Martin, A.
1 / 42 shared
Jeandin, Michel
1 / 40 shared
Proudhon, Henry
1 / 74 shared
Dinglreiter, H.
1 / 1 shared
Schubert, N.
1 / 1 shared
Langklotz, U.
1 / 4 shared
Amann, T.
1 / 6 shared
Krummhauer, O.
1 / 3 shared
Kailer, A.
1 / 31 shared
Schulze, V.
1 / 48 shared
Erman Tekkaya, A.
1 / 20 shared
Munzinger, C.
2 / 2 shared
Kleiner, M.
1 / 24 shared
Selvaggio, A.
2 / 11 shared
Becker, D.
2 / 7 shared
Koehler, G.
1 / 1 shared
Ruhstorfer, M.
1 / 4 shared
Elser, J.
1 / 2 shared
Michael, M.
1 / 2 shared
Brosius, A.
1 / 61 shared
Köhler, G.
1 / 1 shared
Tekkaya, Ae
1 / 822 shared
Ruch, D.
1 / 9 shared
Gerbracht, T.
1 / 1 shared
Ochs, A.
1 / 1 shared
Huber, S.
1 / 10 shared
Lanza, G.
1 / 4 shared
Zäh, S. M. F.
1 / 1 shared
Stenzel, V.
1 / 4 shared
Plagemann, P.
1 / 5 shared
Momber, A. W.
1 / 8 shared
Wiegemann, M.
1 / 2 shared
Schilm, J.
1 / 15 shared
Schroth, S.
2 / 2 shared
Krempasky, J.
1 / 3 shared
Falub, M. C.
2 / 2 shared
Hricovini, K.
1 / 5 shared
Herger, R.
2 / 4 shared
Falub, C. V.
2 / 8 shared
Willmott, P. R.
2 / 7 shared
Patthey, L.
2 / 7 shared
Shi, M.
2 / 8 shared
Franssen, Jean-Marc
1 / 18 shared
Schneider, U.
1 / 5 shared
Endler, I.
3 / 9 shared
Westphal, H.
3 / 4 shared
Pitonak, R.
3 / 6 shared
Berg, H. Van Den
3 / 8 shared
Ruppi, S.
3 / 4 shared
Höhn, M.
2 / 4 shared
Fürbeth, W.
2 / 7 shared
Weidmann, S. K.
2 / 2 shared
Mayer-Uhma, T.
1 / 1 shared
Klemm, V.
3 / 68 shared
Schreiber, G.
2 / 31 shared
Yezerska, O.
2 / 3 shared
Rafaja, David
2 / 293 shared
Masimov, M.
2 / 4 shared
Galle, K.
1 / 1 shared
Canulescu, S.
1 / 5 shared
Lippert, Th.
1 / 5 shared
Robert, R.
2 / 11 shared
Wokaun, A.
2 / 18 shared
Weidenkaff, A.
2 / 39 shared
Döbeli, M.
2 / 30 shared
Logvinovich, D.
2 / 13 shared
Schneider, J. M.
1 / 25 shared
Hallstedt, B.
1 / 4 shared
Steinbach, I.
1 / 13 shared
Walter, C.
1 / 7 shared
Gerdemann, F.
1 / 2 shared
Jannot, E.
1 / 1 shared
Warnken, Nils
1 / 40 shared
Gottstein, G.
1 / 3 shared
Prahl, U.
1 / 10 shared
Bleck, W.
1 / 15 shared
Mohles, V.
1 / 4 shared
Canulescu, Stela
1 / 57 shared
Doebeli, M.
1 / 2 shared
Lippert, T. H.
1 / 1 shared
Naupert, M.
1 / 1 shared
Lipp, D.
3 / 7 shared
Drechsler, S.-L.
3 / 16 shared
Gladun, A.
3 / 6 shared
Fuchs, G.
3 / 33 shared
Müller, K.-H.
2 / 28 shared
Nenkov, K.
3 / 35 shared
Freudenberger, Jens
3 / 150 shared
Michel, S.
1 / 12 shared
Stein, Nicolas
1 / 16 shared
Lecuire, Jm.
1 / 1 shared
Boulanger, C.
1 / 2 shared
Cichorek, T.
2 / 4 shared
Gegenwart, P.
2 / 8 shared
Mülcer, K.-H.
1 / 1 shared
Chart of publication period
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2002

Co-Authors (by relevance)

  • Karafiludis, Stephanos
  • Manzoni, Anna M.
  • Laplanche, G.
  • Mohring, W.
  • Stephan-Scherb, C.
  • Hilgenberg, Kai
  • Schlingmann, T.
  • Bettge, Dirk
  • Binder, M.
  • Schmidt, J.
  • Klöden, B.
  • Welschinge, F.
  • Magino, Nicola
  • Köbler, Jonathan
  • Andrä, Heiko
  • Müller, R.
  • Abubakar, Abba A.
  • Al-Athel, K. S.
  • Shahzamanian, M. M.
  • Akhtar, S. S.
  • Basirun, W. J.
  • Shakelly, N.
  • Hakeem, Abbas Saeed
  • Wu, P. D.
  • Arif, A. F. M.
  • Akhtar, Syed Sohail
  • Hilgenberg, K.
  • Dreyer, M.
  • Dollmeier, K.
  • Bettge, D.
  • Schmidt, Jonathan
  • Boerner, Andreas
  • Schroepfer, Dirk
  • Saliwan Neumann, Romeo
  • Richter, Tim
  • Rhode, Michael
  • Siemensmeyer, K.
  • De Oliveira Guilherme Buzanich, Ana
  • Yusenko, Kirill
  • Reinholz, Uwe
  • Abrudan, R.
  • Kuzmin, A.
  • Smekhova, A.
  • Hdc, Smyth
  • Wu, T.
  • Khalaf, Ryan
  • Brunaugh, Ashlee
  • Ding, Li
  • Manzoni, Anna Maria
  • Schröpfer, Dirk
  • Stephan-Scherb, Christiane
  • Schulz, Wencke
  • Cristofolini, I.
  • Arnhold, V.
  • Sicre, J.
  • Toledo, D.
  • Molinari, A.
  • Dougan, M.
  • Weber, H.
  • Bonnefoy, V.
  • Kruzhanov, V.
  • Vervoort, P.
  • Larsson, C.
  • Baumgartner, F.
  • Hellein, R.
  • Wimbert, L.
  • Welschinger, F.
  • Staub, S.
  • Köbler, J.
  • Andrä, H.
  • Gebhardt, A.
  • Götz, T.
  • Esch, P.
  • Modler, Nils
  • Vogel, C.
  • Striegel, A.
  • Benkel, Ch.
  • Worgull, M.
  • Schneider, N.
  • Steeb, H.
  • Volk, W.
  • Lechner, P.
  • Ettemeyer, F.
  • Hofmann, T.
  • Ospald, F.
  • Erhart, A.
  • Haufe, A.
  • Biasutti, M.
  • Hagstrom, J.
  • Croizet, D.
  • Stenberg, N.
  • Zapara, M.
  • Butz, A.
  • Kampczyk, M.
  • Sbierski, Björn
  • Brouwer, Piet W.
  • Rivron, N. C.
  • Kolew, A.
  • Heilig, M.
  • Espinoza, S.
  • Van Blitterswijk, Clemens A.
  • Vrij, Erik
  • Truckenmüller, Roman
  • Franzreb, Matthias
  • Steinmetz, H.
  • Gellermann, Carsten
  • Meyer, C.
  • Drenkova-Tuhtan, Asya
  • Mandel, Karl
  • Sextl, G.
  • Watté, J.
  • Van Erps, Jurgen
  • Besser, H.
  • Barie, N.
  • Wissmann, M.
  • Hofmann, A.
  • Guttmann, M.
  • Beri, Stefano
  • Pfleging, W.
  • Wissmann, Markus
  • Erps, J. Van
  • Beri, S.
  • Watte, J.
  • Hölscher, H.
  • Reinhard, M.
  • Meier, Tobias
  • Bur, J.
  • Cuniberti, Gianaurelio
  • Heubner, C.
  • Roode-Gutzmer, Q.
  • Hess, A.
  • Michaelis, A.
  • Bobeth, M.
  • Weiser, M.
  • Kaskel, S.
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article

Identification of Stability Constraints in the Particle Engineering of an Inhaled Monoclonal Antibody Dried Powder.

  • Schneider, M.
  • Hdc, Smyth
  • Wu, T.
  • Khalaf, Ryan
  • Brunaugh, Ashlee
  • Ding, Li
Abstract

Monoclonal antibody (mAb) based therapies may provide a valuable new treatment modality for acute and chronic lung diseases, including asthma, respiratory infections, and lung cancer. Currently mAbs are delivered via systemic administration routes, but direct delivery to the lungs via the inhaled route could provide higher concentrations at the site of disease and reduced off-target effects. Though lyophilized mAbs may be reconstituted and delivered to the lungs using nebulizers, dry powder inhalers provide a more patient-friendly delivery method based upon their fast administration time and portability. However, particle engineering processes required to prepare respirable dried powders for DPI delivery involve multiple potential stressors for mAbs, which have not been fully explored. In this study, a systematic examination of various aspects of the particle engineering process (atomization, freezing, drying, and storage) was performed to further understand their impact on mAb structure and aggregation. Using anti-streptavidin IgG1 as a model mAb, atomization settings were optimized using a design of experiments approach to elucidate the relationship between feed flow rate, formulation solid content, and atomization airflow rate and protein structural changes and aggregation. The optimized atomization conditions were then applied to spray drying and spray freezing drying particle engineering processes to determine the effects of freezing and drying on IgG1 stability and aerosol performance of the powders. IgG1 was found to be particularly susceptible to degradation induced by the expansive air-ice interface generated by spray freeze drying and this process also produced powders that exhibited decreased storage stability. This study further delineates the design space for manufacturing of respirable biologic therapies and is intended to serve as a roadmap for future development work.

Topics
  • impedance spectroscopy
  • experiment
  • drying
  • atomization