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Pawłowska, Agata
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article
Perfluorophenyl phosphonate analogues of aromatic amino acids: Synthesis, X-ray and DFT studies
Abstract
Novel perfluorophenyl phosphonate analogues of phenylglycine and homophenylalanine were prepared in good to excellent yields, and subjected to solid state characterization by single-crystal X-ray diffraction analysis, and to investigations with the use of DFT methods. The α-aminophosphonates have a big potential for biological activity, and through S<sub>N</sub>Ar reactions may give an entrance to further structurally variable analogues of both amino acids.</p>