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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Hasan, Abshar
University of Nottingham
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (5/5 displayed)
- 2020Growth‐factor free multicomponent nanocomposite hydrogels that stimulate bone formationcitations
- 2018Laser cladding with HA and functionally graded TiO2-HA precursors on Ti–6Al–4V alloy for enhancing bioactivity and cyto-compatibilitycitations
- 2018Surface Functionalization of Ti6Al4V via Self-assembled Monolayers for Improved Protein Adsorption and Fibroblast Adhesioncitations
- 2018Nano-biocomposite scaffolds of chitosan, carboxymethyl cellulose and silver nanoparticle modified cellulose nanowhiskers for bone tissue engineering applicationscitations
- 2017A novel bio-sorbent comprising encapsulated Agrobacterium fabrum (SLAJ731) and iron oxide nanoparticles for removal of crude oil co-contaminant, lead Pb(II)citations
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article
Laser cladding with HA and functionally graded TiO2-HA precursors on Ti–6Al–4V alloy for enhancing bioactivity and cyto-compatibility
Abstract
In the present study, the morphology and composition of Titanium alloy (Ti–6Al–4 V) surfaces were modified by laser cladding (LC) process to enhance the biocompatibility and bioactivity of orthopaedic implants. Ti–6Al–4 V substrates were processed using a pulsed Nd:YAG laser with various precursors: 100% HA and functionally graded TiO2-HA material (FGM). A set of laser parameters having 21.6 J/mm2 laser energy density or irradiance was applied for cladding, to execute a comparative study. The morphology, phases and wettability with different biological tests including bioactivity, protein adsorption, cell adhesion and cyto-compatibility were performed on cladded samples. The FGM cladding showed higher apatite precipitation than 100% HA cladding. Both LC samples had significantly higher amount of protein adsorption lead to higher cell adhesion and cyto-compatibility compared to non-cladded Ti-6Al-4 V alloy. In between the LC samples, FGM cladding had more protein adsorption and cell adhesion than 100% HA cladding. With six days of incubation, the proliferation rate of FGM cladding (215.6 ± 17.2%) was significantly higher than 100%HA cladding (134.6 ± 9.5%) and non-cladded Ti–6Al–4 V control (100%). All these outcomes reveal that the LC process improves the biocompatibility and bioactivity of Ti–6Al–4 V.