| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Aguiar-Ricardo, Ana
Universidade Nova de Lisboa
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (15/15 displayed)
- 2020Cyclodextrin solubilization and complexation of antiretroviral drug lopinavir: In silico prediction; Effects of derivatization, molar ratio and preparation methodcitations
- 2018Preparation of ibuprofen/hydroxypropyl-Γ-cyclodextrin inclusion complexes using supercritical CO2-assisted spray dryingcitations
- 2017Supercritical CO2-assisted spray drying of strawberry-like gold-coated magnetite nanocomposites in chitosan powders for inhalationcitations
- 2017Bioactivity, mechanical properties and drug delivery ability of bioactive glass-ceramic scaffolds coated with a natural-derived polymercitations
- 2016Design of experiments approach on the preparation of dry inhaler chitosan composite formulations by supercritical CO2-assisted spray-dryingcitations
- 2015Design of oligoaziridine-PEG coatings for efficient nanogold cellular biotaggingcitations
- 2015POxylated Polyurea Dendrimerscitations
- 2014Polyurea dendrimer for efficient cytosolic siRNA deliverycitations
- 2014Development of dual-responsive chitosan-collagen scaffolds for pulsatile release of bioactive moleculescitations
- 2012Dual stimuli responsive poly(N-isopropylacrylamide) coated chitosan scaffolds for controlled release prepared from a non residue technologycitations
- 2012Biocompatible polyurea dendrimers with pH-dependent fluorescencecitations
- 2008Preparation of membranes with polysulfone/polycaprolactone blends using a high pressure cell specially designed for a CO2-assisted phase inversioncitations
- 2008Ultrasonic energy as a tool in the sample treatment for polymer characterization through matrix-assisted laser desorption ionization time-of-flight mass spectrometrycitations
- 2007Boron trifluoride catalyzed polymerisation of 2-substituted-2-oxazolines in supercritical carbon dioxidecitations
- 2006Visual and acoustic investigation of the critical behavior of mixtures of CO2 with a perfluorinated polyethercitations
Places of action
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article
Design of experiments approach on the preparation of dry inhaler chitosan composite formulations by supercritical CO2-assisted spray-drying
Abstract
<p>Pulmonary delivery is very attractive as potential route for non-invasive administration of active ingredients to the lungs, by dry powder inhalation, either for directly target the lungs or render a systemic therapeutic effect. Besides biocompatibility, non-toxicity and biodegradability, dry powders must fulfil main particle requirements in terms of performance delivery in order to be considered suitable carriers for dry pulmonary therapeutics, such as size, density and aerodynamic properties. The development of such particles typically involves a complex process of optimization. In this work a design of experiments approach (DoE) was used to study the effect of supercritical CO<sub>2</sub>-assisted spray-drying (SASD) operational parameters in the final properties of composite chitosan (CHT) microparticles. The effect of CO<sub>2</sub> to liquid flow ratio (R), atomization temperature and the co-atomization of a model active ingredient, ibuprofen (IBP), was studied with respect to the particle volumetric diameter (D<sub>v,50</sub>), span, mass median aerodynamic diameter (MMAD), fine particle fraction (FPF), geometric standard deviation (GSD) and emitted fraction (EF). The in vitro aerosolization profile of the powders was assessed using an Anderson Cascade Impactor (ACI) equipment able to simulate the deposition of the particles in the lungs. In addition, in vitro release studies from the composite particle formulations were performed and modelled using the Korsmeyer-Peppas equation, as well as lysozyme biodegradation experiments. We were able to develop dry chitosan composite particles with suitable characteristics for the delivery of active ingredients to the lungs. Design of experiments approach was able to statistically correlate the operational conditions with the final characteristics of the formulation.</p>