| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Keller, Stephan Urs
Technical University of Denmark
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (34/34 displayed)
- 2024In-situ mineralization of biomass-derived hydrogels boosts capacitive electrochemical energy storage in free-standing 3D carbon aerogelscitations
- 2022Stereolithography-Derived Three-Dimensional Pyrolytic Carbon/Mn3O4 Nanostructures for Free-Standing Hybrid Supercapacitor Electrodescitations
- 2022Selective Passivation of Three-Dimensional Carbon Microelectrodes by Polydopamine Electrodeposition and Local Laser Ablationcitations
- 2021Hot punching for loading of biodegradable microcontainers with budesonide-Soluplus filmcitations
- 2021Suspended highly 3D interdigitated carbon microelectrodescitations
- 2020Highly structured 3D pyrolytic carbon electrodes derived from additive manufacturing technologycitations
- 2019Where Is the Drug? Quantitative 3D Distribution Analyses of Confined Drug-Loaded Polymer Matricescitations
- 2019Pyrolytic carbon resonators for micromechanical thermal analysiscitations
- 2019Wafer-Scale Polymer-Based Transparent Nanocorals with Excellent Nanoplasmonic Photothermal Stability for High-Power and Superfast SERS Imagingcitations
- 2017Suspended 3D pyrolytic carbon microelectrodes for electrochemistrycitations
- 2017Suspended microstructures of epoxy based photoresists fabricated with UV photolithographycitations
- 2017High temperature SU-8 pyrolysis for fabrication of carbon electrodescitations
- 2016Bioengineering of Solution Processed Graphene for the Development of Ultrasensitive Flexible Biosensing Platform
- 2016Pyrolytic 3D Carbon Microelectrodes for Electrochemistry
- 2016Microcontainers for Intestinal Drug Delivery
- 2016Pyrolytic carbon microelectrodes for impedance based cell sensingcitations
- 2016Supercritical impregnation of polymer matrices spatially confined in microcontainers for oral drug delivery: Effect of temperature, pressure and timecitations
- 2016Synthesis and characterization of UV photocrosslinkable hydrogels with poly(N-vinyl-2-pyrrolidone): Determination of the network mesh size distributioncitations
- 2015Fabrication of Ni stamp with high aspect ratio, two-leveled, cylindrical microstructures using dry etching and electroplatingcitations
- 2015Microcantilever sensors for fast analysis of enzymatic degradation of poly (D, L-lactide)citations
- 2015Fabrication and loading of oral drug delivery microcontainers using hot punching
- 2015Hot punching of high-aspect-ratio 3D polymeric microstructures for drug deliverycitations
- 2014Physical characterization of photocrosslinked poly(vinyl pyrrolidone) (PVP) hydrogels for drug delivery
- 2014Micromechanical String Resonators: Analytical Tool for Thermal Characterization of Polymerscitations
- 2013Spray coating of microcontainers with eudragit using ferromagnetic shadow masks for controlled oral release of poorly water soluble drugs.
- 2013Sensitive determination of the Young's modulus of thin films by polymeric microcantileverscitations
- 2013Biodegradable microcontainers as an oral drug delivery system for poorly soluble drugs.
- 2013Ferromagnetic shadow mask for spray coating of polymer patternscitations
- 2013Process optimization of ultrasonic spray coating of polymer filmscitations
- 2012Process Optimization for Spray Coating of Poly (vinyl pyrrolidone)
- 2011Biodegradable micromechanical sensors
- 2011Fabrication and characterization of SRN/SU-8 bimorph cantilevers for temperature sensingcitations
- 2010Double layer resist process scheme for metal lift-off with application in inductive heating of microstructurescitations
- 2008Optimized plasma-deposited fluorocarbon coating for dry release and passivation of thin SU-8 cantileverscitations
Places of action
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article
Supercritical impregnation of polymer matrices spatially confined in microcontainers for oral drug delivery: Effect of temperature, pressure and time
Abstract
The present study is aimed to enhance the oral bioavailability of ketoprofen by inserting it into the matrixof poly(vinylpyrrolidone) (PVP) K10 spatially confined into microcontainers, by means of supercriticalCO2-aided impregnation. Microcontainers are cylindrical reservoirs, with typical sizes in the micrometerrange, with a cavity open on one side, where the drug formulation is loaded. Differently to traditionaltablets, microcontainers have a higher surface area per unit volume, and release the drug only in onedirection. This design is meant to enhance the absorption of problematic drugs, like those with poor sol-ubility in water. In a previous study we introduced a novel technique for drug loading of microcontainers,based on inkjet printing and supercritical impregnation (SCI). We showed that SCI produces accurate andreproducible drug loading for large arrays of microcontainers. In the attempt of enhancing the throughputof the loading methods, we propose the replacement of polymer inkjet printing with an easier man-ual compression of the PVP powder into the microcontainers. As the second step, the polymer powderfilled-microcontainers were submitted to SCI. The separate role of different impregnation parameters(temperature, pressure, time, drug concentration in the supercritical phase) was elucidated with respectto the loading capacity. The microcontainer filling was observed by means of optical macroimaging, X-ray microtomography and scanning electron microscopy. The physical state of the drug was investigatedby means of Raman spectroscopy and compared with selected representative PVP-ketoprofen physicalmixtures. Finally, the drug loading was estimated by means of in vitro dissolution tests.The characterization study shows that the present loading method is a valuable alternative to the onepreviously described. The drug loading can be controlled with high accuracy and reproducibility andthe impregnated drug is in amorphous state. These results demonstrate that SCI can be used as a highthroughput loading technique for microfabricated devices for oral drug delivery.