Materials Map

Discover the materials research landscape. Find experts, partners, networks.

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The Materials Map is an open tool for improving networking and interdisciplinary exchange within materials research. It enables cross-database search for cooperation and network partners and discovering of the research landscape.

The dashboard provides detailed information about the selected scientist, e.g. publications. The dashboard can be filtered and shows the relationship to co-authors in different diagrams. In addition, a link is provided to find contact information.

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The Materials Map is still under development. In its current state, it is only based on one single data source and, thus, incomplete and contains duplicates. We are working on incorporating new open data sources like ORCID to improve the quality and the timeliness of our data. We will update Materials Map as soon as possible and kindly ask for your patience.

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Topics

Publications (62/62 displayed)

  • 2024Flexible Coatings Facilitate pH-Targeted Drug Release via Self-Unfolding Foils2citations
  • 2024Fully Biodegradable Elastomer-Based Device for Oral Macromolecule Delivery1citations
  • 20233D-printed Radiopaque Microdevices with Enhanced Mucoadhesive Geometry for Oral Drug Delivery10citations
  • 2022High-throughput 3d-printingcitations
  • 2022Self-propelled Janus micromotors for pH-responsive release of small molecule drug25citations
  • 2021Hot punching for loading of biodegradable microcontainers with budesonide-Soluplus film3citations
  • 2021The determinant role of fabrication technique in final characteristics of scaffolds for tissue engineering applications:A focus on silk fibroin-based scaffolds34citations
  • 2021Effects of chitosan/chondroitin sulfate polysaccharide lids on amoxicillin drug release from microcontainerscitations
  • 2021The determinant role of fabrication technique in final characteristics of scaffolds for tissue engineering applications34citations
  • 2019Artificial gut-on-a-disc platform to evaluate ph sensitive coatings of oral drug delivery devicescitations
  • 2019Fast and quantitative 2D and 3D orientation mapping using Raman microscopy53citations
  • 2019Where Is the Drug? Quantitative 3D Distribution Analyses of Confined Drug-Loaded Polymer Matrices6citations
  • 2019Thin Film Analysis by Nanomechanical Infrared Spectroscopy16citations
  • 2019Evaluation of the solid state form of tadalafil in sub-micron thin films using nanomechanical infrared spectroscopy6citations
  • 2019Thread-Like Radical-Polymerization via Autonomously Propelled (TRAP) Bots20citations
  • 2019Pyrolytic carbon resonators for micromechanical thermal analysis9citations
  • 2019Wafer-Scale Polymer-Based Transparent Nanocorals with Excellent Nanoplasmonic Photothermal Stability for High-Power and Superfast SERS Imaging17citations
  • 2018Using microcantilever sensors to measure poly(lactic-co-glycolic acid) plasticization by moisture uptake9citations
  • 2018Evaluation of the effects of spray drying parameters for producing cubosome powder precursors16citations
  • 2018Evaluation of the effects of spray drying parameters for producing cubosome powder precursors16citations
  • 2018Injection-Molded Microfluidic Device for SERS Sensing Using Embedded Au-Capped Polymer Nanocones44citations
  • 2017Microcontainers as an oral delivery system for spray dried cubosomes containing ovalbumin42citations
  • 2017Quantitative Detection of Trace Level Cloxacillin in Food Samples Using Magnetic Molecularly Imprinted Polymer Extraction and Surface-Enhanced Raman Spectroscopy Nanopillars86citations
  • 2016Microcontainers for Intestinal Drug Deliverycitations
  • 2016Wafer-Scale Nanopillars Derived from Block Copolymer Lithography for Surface-Enhanced Raman Spectroscopy40citations
  • 2016Supercritical impregnation of polymer matrices spatially confined in microcontainers for oral drug delivery: Effect of temperature, pressure and time29citations
  • 2016Synthesis and characterization of UV photocrosslinkable hydrogels with poly(N-vinyl-2-pyrrolidone): Determination of the network mesh size distribution14citations
  • 2016Triple co-culture cell model as an in vitro model for oral particulate vaccine systemscitations
  • 2016Nonlinear optomechanical measurement of mechanical motion124citations
  • 2015Fabrication of Ni stamp with high aspect ratio, two-leveled, cylindrical microstructures using dry etching and electroplating10citations
  • 2015Microcantilever sensors for fast analysis of enzymatic degradation of poly (D, L-lactide)6citations
  • 2015Fabrication and loading of oral drug delivery microcontainers using hot punchingcitations
  • 2015Hot punching of high-aspect-ratio 3D polymeric microstructures for drug delivery20citations
  • 2014Physical characterization of photocrosslinked poly(vinyl pyrrolidone) (PVP) hydrogels for drug deliverycitations
  • 2014Single-layer graphene on silicon nitride micromembrane resonators31citations
  • 2014Single-layer graphene on silicon nitride micromembrane resonators31citations
  • 2014Micromechanical String Resonators: Analytical Tool for Thermal Characterization of Polymers21citations
  • 2013Spray coating of microcontainers with eudragit using ferromagnetic shadow masks for controlled oral release of poorly water soluble drugs.citations
  • 2013Sensitive determination of the Young's modulus of thin films by polymeric microcantilevers15citations
  • 2013Plasma etching on large-area mono-, multi- and quasi-mono crystalline siliconcitations
  • 2013Plasma etching on large-area mono-, multi- and quasi-mono crystalline siliconcitations
  • 2013Biodegradable microcontainers as an oral drug delivery system for poorly soluble drugs.citations
  • 2013Ferromagnetic shadow mask for spray coating of polymer patterns13citations
  • 2013Process optimization of ultrasonic spray coating of polymer films100citations
  • 2013DNA hybridization sensing for cytogenetic analysiscitations
  • 2012Process Optimization for Spray Coating of Poly (vinyl pyrrolidone)citations
  • 2011Microwave absorption properties of gold nanoparticle doped polymers8citations
  • 2011Biodegradable micromechanical sensorscitations
  • 2011Fabrication and characterization of SRN/SU-8 bimorph cantilevers for temperature sensing18citations
  • 2010Double layer resist process scheme for metal lift-off with application in inductive heating of microstructures12citations
  • 2008Optimized plasma-deposited fluorocarbon coating for dry release and passivation of thin SU-8 cantilevers31citations
  • 2007Reliability of poly 3,4-ethylenedioxythiophene strain gauge24citations
  • 2007Single-mode waveguides with SU-8 polymer core and cladding for MOEMS applications104citations
  • 2005Investigation of the bond strength between the photo-sensitive polymer SU-8 and goldcitations
  • 2005Dry release of all-polymer structures35citations
  • 2005Highly Sensitive Polymer-based Cantilever-sensors for DNA Detection143citations
  • 2004Investigation of the bond strength between the photo-sensitive polymer SU-8 and Aucitations
  • 2003Polymeric mechanical sensors with strain gauge readout in a microfluidic systemcitations
  • 2003Polymeric cantilever arrays for biosensing applications72citations
  • 2003Polymeric Cantilever Arrays for Biosensing Applications72citations
  • 2003Optimised cantilever biosensor with piezoresistive read-out143citations
  • 2002Adsorption kinetics and mechanical properties of thiol-modified DNA-oligos on gold investigated by microcantilever sensors125citations

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Chart of shared publication
Krishnan, Samvrta
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Göncü, Nuray
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Vittorio, Laura De
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Ghavami, Mahdi
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Thilsted, Anil H.
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Christensen, Claus Bo Vöge
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Co-Authors (by relevance)

  • Krishnan, Samvrta
  • Göncü, Nuray
  • Vittorio, Laura De
  • Milián-Guimerá, Carmen
  • Ghavami, Mahdi
  • Mccabe, Reece
  • Thamdrup, Lasse Højlund Eklund
  • Eklund Thamdrup, Lasse Højlund
  • Vila, Eduard Marzo
  • Hwu, Ente
  • Chang, Tien-Jen
  • Kjeldsen, Rolf Bech
  • Christfort, Juliane Fjelrad
  • Zór, Kinga
  • Nielsen, Line Hagner
  • Alstrøm, Tommy Sonne
  • Ilchenko, Oleksii
  • Atladóttir, Sylvía
  • Maric, Tijana
  • Keller, Stephan Urs
  • Abid, Zarmeena
  • Petersen, Ritika Singh
  • Andreoli, Francesca
  • Kristensen, Maja N.
  • Müllertz, Anette
  • Ajalloueian, Fatemeh
  • Khademolqorani, Sanaz
  • Chronakis, Ioannis S.
  • Tavanai, Hossein
  • Kamguyan, Khorshid
  • Ozaltin, Kadir
  • Guimera, Carmen Milian
  • Karakurt, Ilkay
  • Lehocky, Marian
  • Kinahan, David
  • Thoppe Rajendran, Sriram
  • Slipets, Roman
  • Okeyo, Peter Ouma
  • Bachmann, Florian
  • Pilgun, Yuriy
  • Kutsyk, Andrii
  • Poulsen, Henning, F.
  • Todeschini, Matteo
  • Mortensen, Jacob
  • Tentor, Fabio
  • Antalaki, Anastasia
  • Jacobsen, Rasmus D.
  • Mazzoni, Chiara
  • Ceccacci, Andrea Casci
  • Marizza, Paolo
  • Cagliani, Alberto
  • Schmid, Silvan
  • Bose-Goswami, Sanjukta
  • Afifi, Ahmad
  • Samaeifar, Fatemeh
  • Srivastava, Sarvesh Kumar
  • Larsen, Tom
  • Villanueva, Luis Guillermo
  • Larsen, Peter Emil
  • Nguyen, Long Quang
  • Rindzevicius, Tomas
  • Wu, Kaiyu
  • Mansano, Ronaldo D.
  • Alves, Gustavo Marcati A.
  • Bargholz, Mia Travers
  • Rades, Thomas
  • Von Halling Laier, Christoffer
  • Sjøltov, Pernille Bjerg
  • Laier, Christoffer Von Halling
  • Thilsted, Anil H.
  • Viehrig, Marlitt
  • Matteucci, Marco
  • Schmidt, Michael S.
  • Catak, Darmin
  • Boyd, Ben
  • Schmidt, Michael Stenbæk
  • Hansen, Mikkel Fougt
  • Sun, Yi
  • Ashley, Jon
  • Ndoni, Sokol
  • Schulte, Lars
  • Wang, Zhongli
  • Li, Tao
  • Pontoni, L.
  • Moneghini, M.
  • Kikic, I.
  • Zordi, N. De
  • Su, K.
  • Alopaeus, J. F.
  • Zeitler, J. A.
  • Solinas, D.
  • Cortesi, A.
  • Laurini, Erik
  • Goswami, Kaustav
  • Grassi, Mario
  • Posocco, Paola
  • Skov, Anne Ladegaard
  • Grassi, Gabriele
  • Abrami, Michela
  • Larobina, D.
  • Rossi, C. De
  • Boyd, B.
  • Lehr, C-M.
  • Rades, T.
  • Gordon, S.
  • Vanner, M. R.
  • Brawley, G. A.
  • Bowen, W. P.
  • Hansen, Ole
  • Bose, Sanjukta
  • Almdal, Kristoffer
  • Borre, Mads T.
  • Grassi, M.
  • Lapasin, R.
  • Grassi, G.
  • Abrami, M.
  • Marcus, Charles M.
  • Herring, Patrick K.
  • Polzik, Eugene S.
  • Shin, Yong Cheol
  • Usami, Koji
  • Sørensen, Anders S.
  • Kong, Jing
  • Armato, Bartolo
  • Taylor, Jacob M.
  • Zeuthen, Emil
  • Torrijo, Luis Guillermo Villanueva
  • Bagci, Tolga
  • Cassidy, Maja C.
  • Villanueva Torrijo, Luis Guillermo
  • Sommer-Larsen, Peter
  • Bergese, Paolo
  • Depero, Laura Eleonora
  • Federici, Stefania
  • Bontempi, Elza
  • Borgese, Laura
  • Colombi, Paolo
  • Davidsen, Rasmus Schmidt
  • Schmidt Davidsen, Rasmus
  • Nagstrup, Johan
  • Østergaard, Jesper
  • Gordon, Sarah
  • Bosco, Filippo
  • Dimaki, Maria
  • Svendsen, Winnie Edith
  • Brøgger, Anna Line
  • Dapra, Johannes
  • Kwasny, Dorota
  • Rozlosnik, Noemi
  • Tumer, Zeynep
  • Jakobsen, Mogens Havsteen
  • Johansen, Tom Keinicke
  • Jiang, Chenhui
  • Curri, M. L.
  • Ouattara, Lassana
  • Ingrosso, Chiara
  • Krozer, V.
  • Greve, Anders
  • Davis, Zachary James
  • Dohn, Søren
  • Knutzen, Michael
  • Hansen, M. F.
  • Häfliger, Daniel
  • Geschke, Oliver
  • Lillemose, Michael
  • Mateiu, Ramona Valentina
  • Hansen, Thomas Steen
  • Nordström, Maria
  • Zauner, Dan
  • Hübner, Jörg
  • Noguerón, E. Sánchez
  • Johansson, Alicia
  • Gomez, Montserrat
  • Clausen, Bjarne Hans
  • Haefliger, D.
  • Rasmussen, Peter Andreas
  • Nordstrøm, M.
  • Lechuga, L. M.
  • Tamayo, J.
  • Alvarez, M.
  • Sanches-Noguerón, E.
  • Clausen, B.
  • Nordstrom, Maria
  • Johansson, A.
  • Calleja, Montserrat
  • Rasmussen, P. A.
  • Lechuga, Laura M.
  • Tamayo De Miguel, Francisco Javier
  • Rasmussen, Peter
  • Calleja, M.
  • Lechuga, L.
  • Eriksen, S. C.
  • Thaysen, J.
  • Marie, Rodolphe Charly Willy
  • Christensen, Claus Bo Vöge
  • Jensenius, Henriette
  • Thaysen, Jacob
OrganizationsLocationPeople

article

Supercritical impregnation of polymer matrices spatially confined in microcontainers for oral drug delivery: Effect of temperature, pressure and time

  • Boisen, Anja
  • Pontoni, L.
  • Marizza, Paolo
  • Moneghini, M.
  • Kikic, I.
  • Keller, Stephan Urs
  • Zordi, N. De
  • Su, K.
  • Alopaeus, J. F.
  • Zeitler, J. A.
  • Solinas, D.
  • Cortesi, A.
  • Rindzevicius, Tomas
Abstract

The present study is aimed to enhance the oral bioavailability of ketoprofen by inserting it into the matrixof poly(vinylpyrrolidone) (PVP) K10 spatially confined into microcontainers, by means of supercriticalCO2-aided impregnation. Microcontainers are cylindrical reservoirs, with typical sizes in the micrometerrange, with a cavity open on one side, where the drug formulation is loaded. Differently to traditionaltablets, microcontainers have a higher surface area per unit volume, and release the drug only in onedirection. This design is meant to enhance the absorption of problematic drugs, like those with poor sol-ubility in water. In a previous study we introduced a novel technique for drug loading of microcontainers,based on inkjet printing and supercritical impregnation (SCI). We showed that SCI produces accurate andreproducible drug loading for large arrays of microcontainers. In the attempt of enhancing the throughputof the loading methods, we propose the replacement of polymer inkjet printing with an easier man-ual compression of the PVP powder into the microcontainers. As the second step, the polymer powderfilled-microcontainers were submitted to SCI. The separate role of different impregnation parameters(temperature, pressure, time, drug concentration in the supercritical phase) was elucidated with respectto the loading capacity. The microcontainer filling was observed by means of optical macroimaging, X-ray microtomography and scanning electron microscopy. The physical state of the drug was investigatedby means of Raman spectroscopy and compared with selected representative PVP-ketoprofen physicalmixtures. Finally, the drug loading was estimated by means of in vitro dissolution tests.The characterization study shows that the present loading method is a valuable alternative to the onepreviously described. The drug loading can be controlled with high accuracy and reproducibility andthe impregnated drug is in amorphous state. These results demonstrate that SCI can be used as a highthroughput loading technique for microfabricated devices for oral drug delivery.

Topics
  • impedance spectroscopy
  • surface
  • polymer
  • amorphous
  • phase
  • scanning electron microscopy
  • Raman spectroscopy