| People | Locations | Statistics |
|---|---|---|
| Naji, M. |
| |
| Motta, Antonella |
| |
| Aletan, Dirar |
| |
| Mohamed, Tarek |
| |
| Ertürk, Emre |
| |
| Taccardi, Nicola |
| |
| Kononenko, Denys |
| |
| Petrov, R. H. | Madrid |
|
| Alshaaer, Mazen | Brussels |
|
| Bih, L. |
| |
| Casati, R. |
| |
| Muller, Hermance |
| |
| Kočí, Jan | Prague |
|
| Šuljagić, Marija |
| |
| Kalteremidou, Kalliopi-Artemi | Brussels |
|
| Azam, Siraj |
| |
| Ospanova, Alyiya |
| |
| Blanpain, Bart |
| |
| Ali, M. A. |
| |
| Popa, V. |
| |
| Rančić, M. |
| |
| Ollier, Nadège |
| |
| Azevedo, Nuno Monteiro |
| |
| Landes, Michael |
| |
| Rignanese, Gian-Marco |
|
Aguiar-Ricardo, Ana
Universidade Nova de Lisboa
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (15/15 displayed)
- 2020Cyclodextrin solubilization and complexation of antiretroviral drug lopinavir: In silico prediction; Effects of derivatization, molar ratio and preparation methodcitations
- 2018Preparation of ibuprofen/hydroxypropyl-Γ-cyclodextrin inclusion complexes using supercritical CO2-assisted spray dryingcitations
- 2017Supercritical CO2-assisted spray drying of strawberry-like gold-coated magnetite nanocomposites in chitosan powders for inhalationcitations
- 2017Bioactivity, mechanical properties and drug delivery ability of bioactive glass-ceramic scaffolds coated with a natural-derived polymercitations
- 2016Design of experiments approach on the preparation of dry inhaler chitosan composite formulations by supercritical CO2-assisted spray-dryingcitations
- 2015Design of oligoaziridine-PEG coatings for efficient nanogold cellular biotaggingcitations
- 2015POxylated Polyurea Dendrimerscitations
- 2014Polyurea dendrimer for efficient cytosolic siRNA deliverycitations
- 2014Development of dual-responsive chitosan-collagen scaffolds for pulsatile release of bioactive moleculescitations
- 2012Dual stimuli responsive poly(N-isopropylacrylamide) coated chitosan scaffolds for controlled release prepared from a non residue technologycitations
- 2012Biocompatible polyurea dendrimers with pH-dependent fluorescencecitations
- 2008Preparation of membranes with polysulfone/polycaprolactone blends using a high pressure cell specially designed for a CO2-assisted phase inversioncitations
- 2008Ultrasonic energy as a tool in the sample treatment for polymer characterization through matrix-assisted laser desorption ionization time-of-flight mass spectrometrycitations
- 2007Boron trifluoride catalyzed polymerisation of 2-substituted-2-oxazolines in supercritical carbon dioxidecitations
- 2006Visual and acoustic investigation of the critical behavior of mixtures of CO2 with a perfluorinated polyethercitations
Places of action
| Organizations | Location | People |
|---|
article
Dual stimuli responsive poly(N-isopropylacrylamide) coated chitosan scaffolds for controlled release prepared from a non residue technology
Abstract
The first decade of the 21st century saw an increasing interest in the development of devices and biomaterials for delivery of bioactive substances that can be controlled by external stimuli. Herein we report the production of smart partially biodegradable scaffolds that exhibit pH- and temperature-responsive behavior and their effects on the release of a model protein and a drug of low molecular weight. Chitosan (CHT) scaffolds (pH sensitive) were coated/impregnated with a thermoresponsive polymer, poly(N-isopropylacrylamide) (PNIPAAm), by in situ synthesis of PNIPAAm within CHT micropores. Microarchitectural analysis by scanning electron microscopy and mercury intrusion porosimetry demonstrate that the coating of the pores inner structure could be efficiently achieved without a considerable loss of porosity of native CHT-scaffolds. Two different strategies were used to impregnate the polymeric devices: supercritical fluid impregnation for scaffold uptake with a model low molecular weight drug (ibuprofen) and bulk loading to impregnate a model protein (bovine serum albumin, BSA). The release profiles showed a specific pattern according to pH and temperature. PNIPAAm temperature responsiveness is able to control BSA release but ibuprofen (Ibu) release is only mediated by pH environmental conditions. (c) 2011 Elsevier B.V. All rights reserved.