| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Blunn, Gw
University of Portsmouth
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (21/21 displayed)
- 2023Accelerated Degradation of Poly-ε-caprolactone Composite Scaffolds for Large Bone Defectscitations
- 2022Design and in vivo testing of novel single-stage tendon graft using polyurethane nanocomposite polymer for tendon reconstructioncitations
- 2018Novel adaptive finite element algorithms to predict bone ingrowth in additive manufactured porous implantscitations
- 2018Novel adaptive finite element algorithms to predict bone ingrowth in additive manufactured porous implants.
- 2017Clinical cold welding of the modular total hip arthroplasty prosthesiscitations
- 2017Intrinsic osteoinductivity of porous titanium scaffold for bone tissue engineeringcitations
- 2017Fretting corrosion behavior of nitinol spinal rods in conjunction with titanium pedicle screwscitations
- 2016Corrosion at the head-neck interface of current designs of modular femoral componentscitations
- 2016Metal concentrations in the blood and tissues after implantation of titanium growth guidance sliding instrumentationcitations
- 2016Nanohydroxyapatite effect on the degradation, osteoconduction and mechanical properties of polymeric bone tissue engineered scaffoldscitations
- 2015The effect of frictional torque and bending moment on corrosion at the taper interfacecitations
- 2015Lessons from retrievalscitations
- 2015Analysis of retrieved growth guidance sliding LSZ-4D devices for early onset scoliosis and investigation of the use of nitinol rods for this systemcitations
- 2015Silicate-substituted calcium phosphate with enhanced strut porosity stimulates osteogenic differentiation of human mesenchymal stem cellscitations
- 2014Low dose of propranolol does not affect rat osteotomy healing and callus strengthcitations
- 2013Enhanced wear and corrosion in modular tapers in total hip replacement is associated with the contact area and surface topographycitations
- 2011Enhancing the soft tissue seal around intraosseous transcutaneous amputation prostheses using silanized fibronectin titanium alloycitations
- 2008Composite ceramic bone graft substitute in the treatment of locally aggressive benign bone tumours.citations
- 2006Porous Ti-6Al-4V bone replacement materials produced by Selective Laser Sintering (SLS)
- 2004The effect of diamond like carbon and hydroxyapatite coatings on soft tissue reactions to external fixation screws under load
- 2000Fractographic examination of racing greyhound central (navicular) tarsal bone failure surfaces using scanning electron microscopy
Places of action
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article
Metal concentrations in the blood and tissues after implantation of titanium growth guidance sliding instrumentation
Abstract
<p><b>Background</b> - Growth guidance sliding treatment devices, such as Shilla (Medtronic, Minneapolis, MN USA) or LSZ-4D (CONMET, Moscow, Russia), used for the treatment of scoliosis in children who have high growth potential have unlocked fixtures that allow rods to slide during growth of the spine, which avoids periodical extensions. However, the probability of clinical complications associated with metallosis after implantation of such devices is poorly understood. The content of metal ions in the blood and tissues of pediatric patients treated for scoliosis using fusionless growth guidance sliding instrumentation has not yet been investigated.</p><p><b>Purpose</b> - The aim of the present study was to measure the content of metal ions in the blood and tissues surrounding the implanted growth guidance sliding LSZ-4D devices made of titanium alloy (Ti6Al4V), and to identify the incidence of metallosis-associated clinical complications in some patients with these devices.</p><p><b>Study Design</b> - This is a one-center, case-control retrospective study.</p><p><b>Patients Sample</b> - The study group included 25 patients with high growth potential (22 females, 3 males; average age at primary surgery for scoliosis treatment is 11.4±1.2 years old) who had sliding growth guidance instrumentation LSZ-4D (CONMET) implanted on 13 (range: 10-16) spine levels for 6±2 years. The LSZ-4D device was made from titanium alloy Ti6Al4V and consisted of two rectangular section rods and fixture elements. Locked fixtures were used on one spinal level, whereas the others were unlocked (sliding). The control group consisted of 13 patients (12 females and 1 male; 11±1.2 years old) without any implanted devices.</p><p><b>Outcome Measures</b> - The content of Ti, Al, and V metal ions in the whole blood and tissues around the implanted device was measured. The incidences of metallosis-associated complications in the study group were recorded.</p><p><b>Methods</b> - Metal ion content was measured by the inductively coupled mass spectrometry method on quadrupolar NexION 300D (PerkinElmer Inc, Shelton, CT, USA).</p><p><b>Results</b> - Five of 25 patients in the study group developed metallosis-associated complications (two sinuses and three seroma in the lumbar part of the spine). Revisions were carried out in two of these patients. Ninety percent of the patients in the study group had increased content of Ti and V ions in the blood (2.8 and 4 times, respectively). Median content of Ti ions in soft tissues adjacentto implanted sliding device was more than 1,500-fold higher than that of the control group. These levels are much higher than previously reported for spinal instrumentation.</p><p><b>Conclusions</b> - Increased content of Ti and V ions in the blood and especially in tissues around the titanium growth guidance sliding device LSZ-4D accompanied by clinical manifestations (seroma and sinuses) indicates the importance of improving wear resistance of such instrumentation with the coatings and the necessity to exchange sliding instrumentation once the child is fully grown.</p>