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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Amatatongchai, Maliwan
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Publications (3/3 displayed)
- 2021Novel dual-sensor for creatinine and 8-hydroxy-2 '-deoxyguanosine using carbon-paste electrode modified with molecularly imprinted polymers and multiple-pulse amperometrycitations
- 2020Novel amino-containing molecularly-imprinted polymer coating on magnetite-gold core for sensitive and selective carbofuran detection in foodcitations
- 2019Highly sensitive and selective electrochemical paper-based device using a graphite screen-printed electrode modified with molecularly imprinted polymers coated Fe3O4@Au@SiO2 for serotonin determinationcitations
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article
Novel dual-sensor for creatinine and 8-hydroxy-2 '-deoxyguanosine using carbon-paste electrode modified with molecularly imprinted polymers and multiple-pulse amperometry
Abstract
We present a novel amperometric dual-imprinted sensor for simultaneous determination of creatinine (Cre) and 8-hydroxy-2'-deoxyguanosine (8-OHdG) in human urine and serum. The sensor used multiple-pulse amperometric detection in flow injection analysis (MPA-FIA). Copper oxide nanoparticles were coated with the Cre molecularly-imprinted polymer (CuO@MIP), using methacrylic acid as the functional monomer and N, N'-(1,2-dihydroxyethylene) bis-acrylamide as cross-linker. For 8-OHdG sensing, we embedded platinum nanoparticles in reduced graphene oxide and then coated it with guanosine poly-dopamine MIP (PtNPs-rGO@MIP). A carbon paste electrode (CPE) was then formed containing both nanocomposites to give the dual MIP sensor (CuO@MIP and PtNPs-rGO@MIP/CPE). We developed a dual-potential waveform as a function of time, with (Edet.1) (+0.4 V/150 ms) to determine Cre selectively and E-det.2 (+0.6 V/250 ms) to analyze both compounds simultaneously (Cre and 8-OHdG). Subtracting the two signals at 0.6 V and 0.4 V (using a correction factor), respectively, from each other allowed for quantifying 8-OHdG without interference from Cre. The MIP sensor has a linear range of 0.5-150 mu M for creatinine and 0.005-50 mu M for 8-OHdG, with limits of detection in nano-molar level. The proposed method is successfully applied for the simultaneous determination of Cre and 8-OHdG in urine and serum samples.