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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Michrafy, Abderrahim
Universidad de Cantabria
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (10/10 displayed)
- 2018Compaction properties of dry granulated powders based on Drucker–Prager Cap modelcitations
- 2017Computational intelligence models to predict porosity of tablets using minimum featurescitations
- 2016Effect of roll compactor sealing system designs: a finite element analysiscitations
- 2016Effect of roll compactor sealing system designs: A finite element analysiscitations
- 2015Processing fine powders by roll presscitations
- 2013The effect of punch's shape on die compaction of pharmaceutical powderscitations
- 2008Size effect in transient thermal fatigue testing and thermo-mechanical screening of coatingscitations
- 2004Wall friction in the compaction of pharmaceutical powders: measurement and effect on the density distributioncitations
- 2001Heat transfer and thermo-mechanical stresses in a gravity casting die - Influence of process parameterscitations
- 2000Rôle du poteyage et de la température initiale du moule sur les sollicitations thermomécaniques des moules permanents de fonderie
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article
Effect of roll compactor sealing system designs: a finite element analysis
Abstract
In the pharmaceutical industry, the roll compaction is part of the dry granulation process, densifying fine powders into ribbons that will be later milled to produce granules with good flowability for subsequent die compaction process. Roll compactors are constructed with a sealing system, limiting the loss of powder from the sides. However, the sealing system may result in unwanted non-uniformity of the ribbon's properties. In this work, a 3D Finite Elements Method (FEM) modeling is used to analyze the roll compaction process and the effect of sealing system designs on the compacted ribbon's density distribution. A density dependent Drucker-Prager Cap (DPC) constitutive model for microcrystalline cellulose (Avicel PH-101) was calibrated and implemented in Abaqus/Explicit. Two different FEM models were investigated, one with a fixed side sealing called cheek plates and another where the side sealing is integrated with the bottom roll called rimmed-roll. Both numerical and experimental results clearly show the non-uniform roll pressure and density distribution for the cheek plates assembly, whereas the rimmed-roll shows an overall more uniformly distributed resultant pressure and density distribution. These results demonstrate the capability of FEM modeling to provide insight and help achieving a better understanding of the roll compaction process. ; This project has received funding from the European Union's Seventh Framework Programme for research, technological development and demonstration under grant agreement No. 316555. The authors would like to thank Prof. Peter Kleinebudde and Mrs. Ana Pérez Gago from Düsseldorf University for providing scientific, and technical support and recommendations using the Gerteis roll compactor. The authors also thank Dr. Gavin Reynolds and Dr. Andreja Mirtic from AstraZeneca,UK for giving access to the GeoPyc in order to validate this work.