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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Michrafy, Abderrahim
Universidad de Cantabria
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (10/10 displayed)
- 2018Compaction properties of dry granulated powders based on Drucker–Prager Cap modelcitations
- 2017Computational intelligence models to predict porosity of tablets using minimum featurescitations
- 2016Effect of roll compactor sealing system designs: a finite element analysiscitations
- 2016Effect of roll compactor sealing system designs: A finite element analysiscitations
- 2015Processing fine powders by roll presscitations
- 2013The effect of punch's shape on die compaction of pharmaceutical powderscitations
- 2008Size effect in transient thermal fatigue testing and thermo-mechanical screening of coatingscitations
- 2004Wall friction in the compaction of pharmaceutical powders: measurement and effect on the density distributioncitations
- 2001Heat transfer and thermo-mechanical stresses in a gravity casting die - Influence of process parameterscitations
- 2000Rôle du poteyage et de la température initiale du moule sur les sollicitations thermomécaniques des moules permanents de fonderie
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article
The effect of punch's shape on die compaction of pharmaceutical powders
Abstract
This paper investigates the compaction of pharmaceutical powders using different shapes of punches. We introduce a model of mechanical behaviour Drucker-Prager Cap (DPC), using the approach of compressible continuous media. The model parameters that are depending on the material density, were identified from experimental data and a calibration process was applied on Microcrystalline Cellulose (MCC) powder. In addition, the mathematical formulation of the boundary problem of compaction in rigid tools brings back to an optimization problem with constraint, which is solved by finite element method. The Drucker-Prager Cap model, which is implemented in Abaqus/Standard software, was employed using a user subroutine, USDFLD. Three kinds of typical pharmaceutical tablets are considered: flat-face tablet and concave face tablet with two different depths. Results of simulations of die compaction cycle as compression, decompression and ejection, reproduce the powder compaction process for the studied shaped punches. The effects of the punch's shape on the compaction process were observed on the distribution and the maximum of stress and density in the compact. Examination of the density gradient according to the shape, suggests a capping tendency, which increases with the punch depth. This study illustrates the potentiality of the FEM method, which could be used as an efficient tool to predict the density and the stress distributions into shaped compacts and to provide a diagnostic of the capping problems.