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Naji, M. |
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Motta, Antonella |
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Aletan, Dirar |
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Mohamed, Tarek |
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Ertürk, Emre |
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Taccardi, Nicola |
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Kononenko, Denys |
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Petrov, R. H. | Madrid |
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Alshaaer, Mazen | Brussels |
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Bih, L. |
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Casati, R. |
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Muller, Hermance |
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Kočí, Jan | Prague |
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Šuljagić, Marija |
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Kalteremidou, Kalliopi-Artemi | Brussels |
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Azam, Siraj |
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Ospanova, Alyiya |
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Blanpain, Bart |
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Ali, M. A. |
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Popa, V. |
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Rančić, M. |
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Ollier, Nadège |
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Azevedo, Nuno Monteiro |
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Landes, Michael |
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Rignanese, Gian-Marco |
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Michrafy, Abderrahim
Universidad de Cantabria
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (10/10 displayed)
- 2018Compaction properties of dry granulated powders based on Drucker–Prager Cap modelcitations
- 2017Computational intelligence models to predict porosity of tablets using minimum featurescitations
- 2016Effect of roll compactor sealing system designs: a finite element analysiscitations
- 2016Effect of roll compactor sealing system designs: A finite element analysiscitations
- 2015Processing fine powders by roll presscitations
- 2013The effect of punch's shape on die compaction of pharmaceutical powderscitations
- 2008Size effect in transient thermal fatigue testing and thermo-mechanical screening of coatingscitations
- 2004Wall friction in the compaction of pharmaceutical powders: measurement and effect on the density distributioncitations
- 2001Heat transfer and thermo-mechanical stresses in a gravity casting die - Influence of process parameterscitations
- 2000Rôle du poteyage et de la température initiale du moule sur les sollicitations thermomécaniques des moules permanents de fonderie
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article
Wall friction in the compaction of pharmaceutical powders: measurement and effect on the density distribution
Abstract
Issu de : APHYS 2003 - 1st International Meeting on Applied Physics, Badajoz, SPAIN, OCT 13-18, 2003. Ce numéro spécial reprend après révision certains papiers du congrès. ; International audience ; In this paper, the axial density profile of tablets of microcrystal line cellulose (MCC) powder compacted in nonlubricated die is investigated by finite element modelling (FEM). The Drucker-Prager/Cap model was adopted for the compaction behavior of powder. The material parameters of the model, including the die wall friction coefficient, were estimated from experimental data of die compaction where the initial density of powder is taken uniform. Changes of Young's modulus with density was measured with a four-point beam bending test. The results of the simulation of the compression and the decompression steps were used to calculate the axial density distribution. Comparison with the measured data presented in [A. Michrafy, M.S. Kadiri, J.A.D. Dodds. Wall friction and its effects on the density distribution in the compaction of pharmaceutical excipients, Chem. Eng. Research and Design. Vol. 81. Part A. September (2003)] is discussed.