| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Al-Malaika, Sahar
Aston University
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (18/18 displayed)
- 2021Influence of anti-ageing compounds on rheological properties of bitumencitations
- 2021Effect of processing conditions and catalyst type on the thermal oxidative degradation mechanisms and melt stability of metallocene and Ziegler‐catalyzed ethylene‐1‐hexene copolymerscitations
- 2021New and novel stabilisation approach for radiation-crosslinked Ultrahigh Molecular Weight Polyethylene (XL-UHMWPE) targeted for use in orthopeadic implantscitations
- 2020Photo-stabilization of biopolymers-based nanocomposites with UV-modified layered silicatescitations
- 2017Novel strategic approach for the thermo- and photo-oxidative stabilization of polyolefin/clay nanocompositescitations
- 2017Novel strategic approach for the thermo- and photo- oxidative stabilization of polyolefin/clay nanocompositescitations
- 2017Thermo-oxidative stabilization of poly(lactic acid)-based nanocomposites through the incorporation of clay with in-built antioxidant activitycitations
- 2015Novel organo-modifier for thermally-stable polymer-layered silicate nanocompositescitations
- 2013Influence of processing and clay type on nanostructure and stability of polypropylene-clay nanocompositescitations
- 2011Effect of contact surfaces on the thermal and photoxidation of dehydrated castor oilcitations
- 2010Reactive processing of polymerscitations
- 2009Effect of extrusion and photo-oxidation on polyethylene/clay nanocompositescitations
- 2009Reactive processing of polymers: structural characterization of products by 1H and 13C NMR spectroscopy for glycidyl methacrylate grafting onto EPR in the absence and presence of a reactive comonomercitations
- 2008Special issue of PDS - Based on PDDG meeting, Aston University, September 2007, in honour of Professor Norman Billingham
- 2006Metallocene ethylene-1-octene copolymerscitations
- 2005Polymer degradation and stabilitycitations
- 2004Perspectives in stabilisation of polyolefinscitations
- 2003Oxidative degradation and stabilisation of polymerscitations
Places of action
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article
New and novel stabilisation approach for radiation-crosslinked Ultrahigh Molecular Weight Polyethylene (XL-UHMWPE) targeted for use in orthopeadic implants
Abstract
<p>There is a substantial evidence to show that oxidative degradation has a negative impact on the properties and performance of radiation-crosslinked ultra high molecular weight polyethylene (XL-UHMWPE) used as articulating components in orthopaedic joint implants and is the primary cause for their premature failure. In general, high energy radiation is required not only for sterilising the articulating surfaces but also for crosslinking the polymer to improving its mechanical properties and wear resistance thus minimising the extent of formation of wear-particles which are implicated in the aseptic loosening and failure of the implant. To address the oxidative stability of the XL-UHMWPE bearing surfaces, the natural hindered phenol antioxidant, vitamin E, which has been approved by FDA for use in this application, is used to enhance the oxidation resistance of orthopaedic implants, e.g. in tibial bearings. Further, a purified grade of the commercial antioxidant Irganox 1010<sup>Ⓡ</sup> (pentaerythritol tetrakis(3-[3,5-di tertiary butyl‑4‑hydroxy phenyl]propionate) has also been FDA approved and used in some knee-based systems. In the case of vitamin E, its effectiveness as a potent free radical scavenger, however, presents some issues in respect of the polymer crosslinking process and the homogeneity of its distribution especially during manufacturing processes that involve the infusion of the vitamin into the polymer. The novel approach adopted in this study for the stabilisation of XL-UHMWPE bearing surfaces makes use of graftable polymer-reactive antioxidants (r-AOs) bearing a hindered phenol and also hindered amine moieties. Potentially, these r-AOs can be chemicaly grafted in-situ on the polymer backbone during the radiation-crosslinking process without the need for any additional manufacturing step. The results obtained have demonstrated a substantive stabilisation which can be achieved with these r-AOs. This was shown to be the case in all the XL-UHMWPE samples tested here which were manufactured according to a methodology typically used in the commercial production and crosslinking (by gamma- or electron-beam) of UHMWPE-based implants.</p>