| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Choińska, Emilia
Warsaw University of Technology
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (16/16 displayed)
- 2024A comparative study of oxidation behavior of Co4Sb12 and Co4Sb10.8Se0.6Te0.6 skutterudite thermoelectric materials fabricated via fast SHS-PPS routecitations
- 20223D-Printed Drug Delivery Systems: The Effects of Drug Incorporation Methods on Their Release and Antibacterial Efficiency
- 2022The Utility of Recycled Rice Husk-Reinforced PVC Composite Profiles for Façade Claddingcitations
- 2021Biological and Corrosion Evaluation of In Situ Alloyed NiTi Fabricated through Laser Powder Bed Fusion (LPBF)citations
- 2021Plasma modification of carbon coating produced by RF CVD on oxidized NiTi shape memory alloy under glow-discharge conditionscitations
- 2020Molding Binder Influence on the Porosity and Gas Permeability of Ceramic Casting Moldscitations
- 2020The effect of diameter of fibre on formation of hydrogen bonds and mechanical properties of 3D-printed PCLcitations
- 2020The effect of introduction of filament shift on degradation behaviour of PLGA- and PLCL-based scaffolds fabricated via additive manufacturingcitations
- 2019Engineering Human-Scale Artificial Bone Grafts for Treating Critical-Size Bone Defectscitations
- 2018Nanobead-on-string composites for tendon tissue engineeringcitations
- 2018Micro and nanoscale characterization of poly(DL-lactic-co-glycolic acid) films subjected to the L929 cells and the cyclic mechanical loadcitations
- 2018Multi-scale characterization and biological evaluation of composite surface layers produced under glow discharge conditions on NiTi shape memory alloy for potential cardiological applicationcitations
- 2017Radiopaque biodegradable polymeric composites for in vivo monitoring of TE products by X-rays imaging
- 2016Increase of radiopacity of PCL scaffolds for their in vivo monitoring using x – rays imaging
- 2016Fabrication and characterization of electrospun bionanocomposites of poly (vinyl alcohol)/ nanohydroxyapatite/ cellulose nanofiberscitations
- 2013Investigations of polycaprolactone / gelatin blends in terms of their miscibilitycitations
Places of action
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article
The effect of introduction of filament shift on degradation behaviour of PLGA- and PLCL-based scaffolds fabricated via additive manufacturing
Abstract
<p>The degradation rate of polyester scaffolds has been emphasised as one of the main areas of concern in bone tissue engineering. In ideal conditions, the degradation of polymeric constructs should match regeneration of the injured tissue. Thus, there is an imperative need to strictly define and understand determinants influencing the degradation rate of scaffolds. In this study, we focused on the effect of filament shift introduction on degradation behaviour of the polymeric-based scaffolds. The poly(L-lactide-co-glycolide) (PLGA), poly(L-lactide-co-ε-caprolactone) (PLCL) and their tricalcium-phosphate-loaded (TCP) composites containing 20 and 40 wt% of filler, were utilized to fabricate constructs using modified fused deposition modeling (FDM). The scaffolds were designed with filament lay-down pattern of 0°/90° and with or without the modifications of filament distance in n+2 layer, shifted and non-shifted constructs were obtained, respectively. To investigate the degradation profile, the change of mass, pH, water absorption and initial molecular weight (M<sub>w0</sub>) loss was observed during the degradation study in phosphate buffered saline (PBS) at 37 °C for up to 48 weeks. The scaffold morphology was evaluated utilizing scanning electron microscopy (SEM) and the visualization of the topography was performed utilizing atomic force microscopy (AFM). Surface area to volume ratio (SVR) and porosity were determined using micro-computed tomography (μCT). The fluid flow simulations were used to define the permeability of two investigated groups of scaffolds. The results of this study clearly demonstrate the accelerating effect of filament shift introduction on degradation behaviour in the scaffolds with similar porosity and SVR. The decrease of M<sub>w0</sub> was significantly higher in case of all shifted samples. We assume that faster degradation of shifted constructs may be attributed to their tortuosity, making them less permeable and prone to the degradation, as the result of the accumulation of acidic products in the tortuous architecture of the samples. Thus, the effect of introduction of filament shift into scaffold architecture comprise an attractive approach to influence the degradation rate in case of bone regeneration with the use of polyesters scaffolds.</p>