| People | Locations | Statistics |
|---|---|---|
| Naji, M. |
| |
| Motta, Antonella |
| |
| Aletan, Dirar |
| |
| Mohamed, Tarek |
| |
| Ertürk, Emre |
| |
| Taccardi, Nicola |
| |
| Kononenko, Denys |
| |
| Petrov, R. H. | Madrid |
|
| Alshaaer, Mazen | Brussels |
|
| Bih, L. |
| |
| Casati, R. |
| |
| Muller, Hermance |
| |
| Kočí, Jan | Prague |
|
| Šuljagić, Marija |
| |
| Kalteremidou, Kalliopi-Artemi | Brussels |
|
| Azam, Siraj |
| |
| Ospanova, Alyiya |
| |
| Blanpain, Bart |
| |
| Ali, M. A. |
| |
| Popa, V. |
| |
| Rančić, M. |
| |
| Ollier, Nadège |
| |
| Azevedo, Nuno Monteiro |
| |
| Landes, Michael |
| |
| Rignanese, Gian-Marco |
|
Chlanda, Adrian
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (15/15 displayed)
- 2024A novel approach to enhance mechanical properties of Ti substrates for biomedical applicationscitations
- 2021Investigation into morphological and electromechanical surface properties of reduced-graphene-oxide-loaded composite fibers for bone tissue engineering applications: A comprehensive nanoscale study using atomic force microscopy approachcitations
- 2020Biological properties of a novel β-Ti alloy with a low young’s modulus subjected to cold rollingcitations
- 2020The effect of diameter of fibre on formation of hydrogen bonds and mechanical properties of 3D-printed PCLcitations
- 2020Internal nanocrystalline structure and stiffness alterations of electrospun polycaprolactone-based mats after six months of in vitro degradation. An atomic force microscopy assaycitations
- 2020The effect of introduction of filament shift on degradation behaviour of PLGA- and PLCL-based scaffolds fabricated via additive manufacturingcitations
- 2018Structure and physico-mechanical properties of low temperature plasma treated electrospun nanofibrous scaffolds examined with atomic force microscopycitations
- 2018The influence of carbon-encapsulated iron nanoparticles on elastic modulus of living human mesenchymal stem cells examined by atomic force microscopycitations
- 2018Nanobead-on-string composites for tendon tissue engineeringcitations
- 2018Micro and nanoscale characterization of poly(DL-lactic-co-glycolic acid) films subjected to the L929 cells and the cyclic mechanical loadcitations
- 2018Multi-scale characterization and biological evaluation of composite surface layers produced under glow discharge conditions on NiTi shape memory alloy for potential cardiological applicationcitations
- 2017Microstructure and nanomechanical properties of single stalks from diatom Didymosphenia geminata and their change due to adsorption of selected metal ionscitations
- 2016.; Influence of biodegradable polymer coatings on corrosion, cytocompatibility and cell functionality of Mg-2.0Zn-0.98Mn magnesium alloycitations
- 2015Quantitative imaging of electrospun fibers by PeakForce Quantitative NanoMechanics Atomic Force Microscopy using etched scanning probescitations
- 2013Three dimensional hybrid scaffolds for bone tissue engineering
Places of action
| Organizations | Location | People |
|---|
article
The effect of introduction of filament shift on degradation behaviour of PLGA- and PLCL-based scaffolds fabricated via additive manufacturing
Abstract
<p>The degradation rate of polyester scaffolds has been emphasised as one of the main areas of concern in bone tissue engineering. In ideal conditions, the degradation of polymeric constructs should match regeneration of the injured tissue. Thus, there is an imperative need to strictly define and understand determinants influencing the degradation rate of scaffolds. In this study, we focused on the effect of filament shift introduction on degradation behaviour of the polymeric-based scaffolds. The poly(L-lactide-co-glycolide) (PLGA), poly(L-lactide-co-ε-caprolactone) (PLCL) and their tricalcium-phosphate-loaded (TCP) composites containing 20 and 40 wt% of filler, were utilized to fabricate constructs using modified fused deposition modeling (FDM). The scaffolds were designed with filament lay-down pattern of 0°/90° and with or without the modifications of filament distance in n+2 layer, shifted and non-shifted constructs were obtained, respectively. To investigate the degradation profile, the change of mass, pH, water absorption and initial molecular weight (M<sub>w0</sub>) loss was observed during the degradation study in phosphate buffered saline (PBS) at 37 °C for up to 48 weeks. The scaffold morphology was evaluated utilizing scanning electron microscopy (SEM) and the visualization of the topography was performed utilizing atomic force microscopy (AFM). Surface area to volume ratio (SVR) and porosity were determined using micro-computed tomography (μCT). The fluid flow simulations were used to define the permeability of two investigated groups of scaffolds. The results of this study clearly demonstrate the accelerating effect of filament shift introduction on degradation behaviour in the scaffolds with similar porosity and SVR. The decrease of M<sub>w0</sub> was significantly higher in case of all shifted samples. We assume that faster degradation of shifted constructs may be attributed to their tortuosity, making them less permeable and prone to the degradation, as the result of the accumulation of acidic products in the tortuous architecture of the samples. Thus, the effect of introduction of filament shift into scaffold architecture comprise an attractive approach to influence the degradation rate in case of bone regeneration with the use of polyesters scaffolds.</p>