| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Idaszek, Joanna
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (10/10 displayed)
- 2023In-depth analysis of the influence of bio-silica filler (Didymosphenia geminata frustules) on the properties of Mg matrix compositescitations
- 2020The effect of diameter of fibre on formation of hydrogen bonds and mechanical properties of 3D-printed PCLcitations
- 2020The effect of introduction of filament shift on degradation behaviour of PLGA- and PLCL-based scaffolds fabricated via additive manufacturingcitations
- 2019The influence of chemical polishing of titanium scaffolds on their mechanical strength and in-vitro cell responsecitations
- 20193D bioprinting of hydrogel constructs with cell and material gradients for the regeneration of full-thickness chondral defect using a microfluidic printing headcitations
- 2018The Influence of Selective Laser Melting (SLM) Process Parameters on In-Vitro Cell Responsecitations
- 2016Post Processing and Biological Evaluation of the Titanium Scaffolds for Bone Tissue Engineeringcitations
- 2016.; Influence of biodegradable polymer coatings on corrosion, cytocompatibility and cell functionality of Mg-2.0Zn-0.98Mn magnesium alloycitations
- 2015Ternary composite scaffolds with tailorable degradation rate and highly improved colonization by human bone marrow stromal cellscitations
- 2012Fabrication of porous poly(3-hydroxybutyrate-co-3-hydroxyvalerate) scaffolds using a Rapid Prototyping Technique
Places of action
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article
The effect of introduction of filament shift on degradation behaviour of PLGA- and PLCL-based scaffolds fabricated via additive manufacturing
Abstract
<p>The degradation rate of polyester scaffolds has been emphasised as one of the main areas of concern in bone tissue engineering. In ideal conditions, the degradation of polymeric constructs should match regeneration of the injured tissue. Thus, there is an imperative need to strictly define and understand determinants influencing the degradation rate of scaffolds. In this study, we focused on the effect of filament shift introduction on degradation behaviour of the polymeric-based scaffolds. The poly(L-lactide-co-glycolide) (PLGA), poly(L-lactide-co-ε-caprolactone) (PLCL) and their tricalcium-phosphate-loaded (TCP) composites containing 20 and 40 wt% of filler, were utilized to fabricate constructs using modified fused deposition modeling (FDM). The scaffolds were designed with filament lay-down pattern of 0°/90° and with or without the modifications of filament distance in n+2 layer, shifted and non-shifted constructs were obtained, respectively. To investigate the degradation profile, the change of mass, pH, water absorption and initial molecular weight (M<sub>w0</sub>) loss was observed during the degradation study in phosphate buffered saline (PBS) at 37 °C for up to 48 weeks. The scaffold morphology was evaluated utilizing scanning electron microscopy (SEM) and the visualization of the topography was performed utilizing atomic force microscopy (AFM). Surface area to volume ratio (SVR) and porosity were determined using micro-computed tomography (μCT). The fluid flow simulations were used to define the permeability of two investigated groups of scaffolds. The results of this study clearly demonstrate the accelerating effect of filament shift introduction on degradation behaviour in the scaffolds with similar porosity and SVR. The decrease of M<sub>w0</sub> was significantly higher in case of all shifted samples. We assume that faster degradation of shifted constructs may be attributed to their tortuosity, making them less permeable and prone to the degradation, as the result of the accumulation of acidic products in the tortuous architecture of the samples. Thus, the effect of introduction of filament shift into scaffold architecture comprise an attractive approach to influence the degradation rate in case of bone regeneration with the use of polyesters scaffolds.</p>