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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Vert, Michel
French National Centre for Scientific Research
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (4/4 displayed)
- 2014Head-to-Head Comparison of a Drug-Free Early Programmed Dismantling Polylactic Acid Bioresorbable Scaffold and a Metallic Stent in the Porcine Coronary Arterycitations
- 2011Thermal and strain-induced chain ordering in lactic acid stereocopolymers: Influence of the composition in stereomerscitations
- 2009Lipase-catalysed degradation of copolymers prepared from e-caprolactone and DL-lactidecitations
- 2003Mechanical properties and lipase-catalyzed biodegradation of alpha-methyl, epsilon-caprolactone/epsilon-caprolactone copolymers obtained by chemical modification of poly(epsilon-caprolactone)
Places of action
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article
Lipase-catalysed degradation of copolymers prepared from e-caprolactone and DL-lactide
Abstract
International audience ; A series of copolymers were prepared by ring-opening polymerization of e-caprolactone and DL-lactide, using zinc lactate as catalyst. The resulting PCL/PLA copolymers were characterized by various analytical techniques such as NMR, SEC, DSC and X-ray diffraction. The [CL]/[LA] ratios of the copolymers are very close to those in the feed, indicating a good conversion of monomers. The copolymers with CL contents higher than 50% appear semi-crystalline, the crystalline structure being of the PCL-type. Compression molded polymer films were allowed to degrade in a pH = 7.0 phosphate buffer containing pseudomonas lipase. Data show that copolymers with CL contents lower than 25% are not degradable and the degradation rate increases with CL content for CL-rich copolymers. Various soluble degradation products are detected in the degradation medium, including CL1 to CL3 and LA1 to LA4 homo-oligomers, and CL2LA1 co-oligomer. The presence of LA homo-oligomers and CL2LA1 co-oligomer suggests that pseudomonas lipase can not only degrades PCL, but also LA short blocks along PCL/PLA copolymer chains. On the other hand, little changes of compositions are detected during degradation, in agreement with a surface erosion mechanism as shown by ESEM.