| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Carugo, Dario
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (7/7 displayed)
- 2021Potential strategies to prevent encrustations on urinary stents and catheters - thinking outside the box: a European network of multidisciplinary research to improve urinary stents (ENIUS) initiativecitations
- 2018Easy-to-perform and cost-effective fabrication of continuous-flow reactors and their application for nanomaterials synthesiscitations
- 2018Easy-to-perform and cost-effective fabrication of continuous-flow reactors and their application for nanomaterials synthesiscitations
- 2013The effect of ultrasound-related stimuli on cell viability in microfluidic channelscitations
- 2012Mechanism of co-nanoprecipitation of organic actives and block copolymers in a microfluidic environmentcitations
- 2012A novel microfluidic approach for the assessment of antifouling technologies
- 2011Continuous-flow production of polymeric micelles in microreactors: experimental and computational analysiscitations
Places of action
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article
Easy-to-perform and cost-effective fabrication of continuous-flow reactors and their application for nanomaterials synthesis
Abstract
The translation of continuous-flow microreactor technology to the industrial environment has been limited by cost and complexity of the fabrication procedures, and the requirement for specialised infrastructure. In the present study, we have developed a significantly cost-effective and easy-to-perform fabrication method for the generation of optically transparent, continuous-flow reactors. The method combines 3D printing of master moulds with sealing of the PDMS channels’ replica using a pressure-sensitive adhesive tape. Morphological characterisation of the 3D printed moulds was performed, and reactors were fabricated with an approximately square-shaped cross-section of 1 mm^2. Notably, they were tested for operation over a wide range of volumetric flow rates, up to 20 ml/min. Moreover, the fabrication time (i.e., from design to the finished product) was <1 day, at an average material cost of ~£5. The flow reactors have been applied to the production of both inorganic nanoparticles (silver nanospheres) and organic vesicular systems (liposomes), and their performance compared with reactors produced using more expensive and laborious fabrication methods. Numerical simulations were performed to characterise the transport of fluids and chemical species within the devices. The developed fabrication method is suitable for scaled-up fabrication of continuous-flow reactors, with potential for application in biotechnology and nanomedicine.