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Wójkowska, Dagmara
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article
Ruthenium metallodendrimer against triple-negative breast cancer in mice
Abstract
Carbosilane metallodendrimers, based on the arene Ru(II) complex (CRD13) and integrated to imino-pyridinesurface groups have been investigated as an anticancer agent in a mouse model with triple-negative breastcancer. The dendrimer entered into the cells efficiently, and exhibited selective toxicity for 4T1 cells. In vivoinvestigations proved that a local injection of CRD13 caused a reduction of tumour mass and was non-toxic. ICPanalyses indicated that Ru(II) accumulated in all tested tissues with a greater content detected in the tumour.