| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Bellucci, Stefano
University of Cassino and Southern Lazio
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (10/10 displayed)
- 2024Sono-synthesis and characterization of next-generation antimicrobial ZnO/TiO2 and Fe3O4/TiO2 bi-nanocomposites, for antibacterial and antifungal applicationscitations
- 2024Studies of Fractal Microstructure in Nanocarbon Polymer Composites
- 2023Tunable optical and semiconducting properties of eco-friendly-prepared reduced graphene oxide
- 2022Synthesis and characterization of MWCNT-COOH/Fe3O4 and CNT-COOH/Fe3O4/NiO nanocomposites: assessment of adsorption and photocatalytic performancecitations
- 2022Study of Barium Adsorption from Aqueous Solutions Using Copper Ferrite and Copper Ferrite/rGO Magnetic Adsorbentscitations
- 2021Oxidized alginate dopamine conjugate: In vitro characterization for nose-to-brain delivery applicationcitations
- 2019Novel non-destructive evaluation technique for the detection of poor dispersion of carbon nanotubes in nanocompositescitations
- 2018Electrical Permittivity and Conductivity of a Graphene Nanoplatelet Contact in the Microwave Rangecitations
- 2016Regulation of angiogenesis through the efficient delivery of microRNAs into endothelial cells using polyamine-coated carbon nanotubescitations
- 2014Dielectric properties of graphite-based epoxy compositescitations
Places of action
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article
Regulation of angiogenesis through the efficient delivery of microRNAs into endothelial cells using polyamine-coated carbon nanotubes
Abstract
MicroRNAs (miRNAs) directly regulate gene expression at a post-transcriptional level and represent an attractive therapeutic target for a wide range of diseases.Here, we report a novel strategy for delivering miRNAs to endothelial cells (ECs) to regulate angiogenesis, using polymer functionalized carbon nanotubes (CNTs). CNTs were coated with two different polymers, polyethyleneimine (PEI) or polyamidoamine dendrimer (PAMAM), followed by conjugation of miR-503 oligonucleotides as recognized regulators of angiogenesis. We demonstrated a reduced toxicity for both polymer-coated CNTs, compared with pristine CNTs or polymers alone. Moreover, polymer-coated CNT stabilized miR-503 oligonucleotides and allowed their efficient delivery to ECs. The functionality of PAMAM-CNT-miR-503 complexes was further demonstrated in ECs through regulation of target genes, cell proliferation and angiogenic sprouting and furthermore, in a mouse model of angiogenesis. This comprehensive series of experiments demonstrates that the use of polyamine-functionalized CNTs to deliver miRNAs is a novel and effective means to regulate angiogenesis.