| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Kozlovskiy, A. L.
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (6/6 displayed)
- 2023STUDY OF THE INFLUENCE OF VARIATIONS IN THE PHASE COMPOSITION ON THE DIELECTRIC PROPERTIES OF FERROELECTRIC CaTiO3 CERAMICS DOPED WITH Y2O3
- 2020Application of Fe2O3/CeO2 nanocomposites for the purification of aqueous mediacitations
- 2020Immobilization of carboranes on Fe3O4-polymer nanocomposites for potential application in boron neutron cancer therapycitations
- 2020Carboranes immobilization on Fe3O4 nanocomposites for targeted deliverycitations
- 2020Stability and cytotoxicity study of NiFe2O4 nanocomposites synthesized by co-precipitation and subsequent thermal annealingcitations
- 2019Study of phase transformations, structural, corrosion properties and cytotoxicity of magnetite-based nanoparticlescitations
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article
Carboranes immobilization on Fe3O4 nanocomposites for targeted delivery
Abstract
Boron neutron capture therapy (BNCT) is promising method of cancer treatment. Success implementation of BNCT depends on effectiveness of selective delivery of boron-rich compound into the cancer cells. In this paper, carboranes with 10 boron atoms per molecule were attached to superparamagnetic nanoparticles for realization of potential magnetic drug targeting. Isopropyl-o-carborane has been successfully immobilized on Fe3O4 nanoparticles (NPs) via covalent bonding with pre-modified surface by tetraethoxysilane (TEOS) and (3-glycidylpropyl) trimethoxysilane (GPTMS). Structure, morphology, element and chemical composition of prepared Fe3O4 NPs were studied by FTIR spectroscopy, X-ray diffraction (XRD), scanning electron microscopy (SEM), Energy-dispersive X-ray spectroscopy (EDA), dynamic light scattering analysis (DLS), Mössbauer spectroscopy and vibrational magnetometer system (VMS). The biocompatibility was evaluated in vitro using different human cancer cell lines: HeLa (cervical cancer cell), PC-3 (prostate cancer cell), HT-29 (colon cancer cell), BxPC-3 (pancreatic cancer cell). Fibroblasts like cells of L929 obtained from subcutaneous adipose tissue of mouse were used as normal cells. Results indicate success immobilization of carboranes on Fe3O4 NPs with low cytotoxicity in concentration range 1–200 μg/mL, and potential to use them as carriers for BNCT.