People | Locations | Statistics |
---|---|---|
Naji, M. |
| |
Motta, Antonella |
| |
Aletan, Dirar |
| |
Mohamed, Tarek |
| |
Ertürk, Emre |
| |
Taccardi, Nicola |
| |
Kononenko, Denys |
| |
Petrov, R. H. | Madrid |
|
Alshaaer, Mazen | Brussels |
|
Bih, L. |
| |
Casati, R. |
| |
Muller, Hermance |
| |
Kočí, Jan | Prague |
|
Šuljagić, Marija |
| |
Kalteremidou, Kalliopi-Artemi | Brussels |
|
Azam, Siraj |
| |
Ospanova, Alyiya |
| |
Blanpain, Bart |
| |
Ali, M. A. |
| |
Popa, V. |
| |
Rančić, M. |
| |
Ollier, Nadège |
| |
Azevedo, Nuno Monteiro |
| |
Landes, Michael |
| |
Rignanese, Gian-Marco |
|
Moroni, Lorenzo
Maastricht University
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (43/43 displayed)
- 2024Well-Defined Synthetic Copolymers with Pendant Aldehydes Form Biocompatible Strain-Stiffening Hydrogels and Enable Competitive Ligand Displacementcitations
- 2023Thiol-ene conjugation of a VEGF peptide to electrospun scaffolds for potential applications in angiogenesiscitations
- 2023Chitin nanofibrils modulate mechanical response in tympanic membrane replacementscitations
- 2023Complementary Supramolecular Functionalization Enhances Antifouling Surfacescitations
- 2023Microstructured click hydrogels for cell contact guidance in 3Dcitations
- 2022Ancient fibrous biomaterials from silkworm protein fibroin and spider silk blends: Biomechanical patternscitations
- 2022Incorporation of Superparamagnetic Iron Oxide Nanoparticles into Collagen Formulation for 3D Electrospun Scaffoldscitations
- 20223D printing of jammed self-supporting microgels with alternative mechanism for shape fidelity, crosslinking and conductivitycitations
- 2022Additive Manufacturing of α-Amino Acid Based Poly(ester amide)s for Biomedical Applicationscitations
- 2022Universal Strategy for Designing ShapeMemory Hydrogelscitations
- 2022Tuning Hydrogels by Mixing Dynamic Cross-Linkers: Enabling Cell-Instructive Hydrogels and Advanced Bioinkscitations
- 2022HOW PRESERVATION PERIOD AFFECT THE BIOLOGICAL PROPERTIES OF ACELLULAR PLACENTAL SPONGE PATCHES?
- 2022Modular mixing of benzene-1,3,5-tricarboxamide supramolecular hydrogelators allows tunable biomimetic hydrogels for control of cell aggregation in 3Dcitations
- 20224D Printed Shape Morphing Biocompatible Materials Based on Anisotropic Ferromagnetic Nanoparticlescitations
- 2021Shaping and properties of thermoplastic scaffolds in tissue regeneration: The effect of thermal history on polymer crystallization, surface characteristics and cell fatecitations
- 2021Biomimetic Mechanically Strong One-Dimensional Hydroxyapatite/Poly(d,l-lactide) Composite Inducing Formation of Anisotropic Collagen Matrixcitations
- 2021Additive manufactured scaffolds for bone tissue engineering: Physical characterization of thermoplastic composites with functional fillerscitations
- 2021Bioprinting Via a Dual-Gel Bioink Based on Poly(Vinyl Alcohol) and Solubilized Extracellular Matrix towards Cartilage Engineeringcitations
- 2021Additive Manufactured Scaffolds for Bone Tissue Engineering: Physical Characterization of Thermoplastic Composites with Functional Fillerscitations
- 2021Controllable four axis extrusion-based additive manufacturing system for the fabrication of tubular scaffolds with tailorable mechanical propertiescitations
- 2021Chitin Nanofibril Application in Tympanic Membrane Scaffolds to Modulate Inflammatory and Immune Responsecitations
- 2021Biomimetic double network hydrogels: Combining dynamic and static crosslinks to enable biofabrication and control cell-matrix interactionscitations
- 20213D porous Ti6Al4V-beta-tricalcium phosphate scaffolds directly fabricated by additive manufacturingcitations
- 2021Long-term preservation effects on biological properties of acellular placental sponge patchescitations
- 2020Additive manufacturing of an elastic poly(ester)urethane for cartilage tissue engineeringcitations
- 20193D-printed bioactive scaffolds from nanosilicates and PEOT/PBT for bone tissue engineeringcitations
- 20193D-printed bioactive scaffolds from nanosilicates and PEOT/PBT for bone tissue engineeringcitations
- 2019Self-assembly of electrospun nanofibers into gradient honeycomb structurescitations
- 2018Influence of the nanofiber chemistry and orientation of biodegradable poly(butylene succinate)-based scaffolds on osteoblast differentiation for bone tissue regenerationcitations
- 2018Biofabrication strategies for 3D in vitro models and regenerative medicinecitations
- 2017Influence of Solution Properties and Process Parameters on the Formation and Morphology of YSZ and NiO Ceramic Nanofibers by Electrospinningcitations
- 2017Influence of Solution Properties and Process Parameters on the Formation and Morphology of YSZ and NiO Ceramic Nanofibers by Electrospinningcitations
- 2016Mimicking natural cell environments: design, fabrication and application of bio-chemical gradients on polymeric biomaterial substratescitations
- 2016Surface energy and stiffness discrete gradients in additive manufactured scaffolds for osteochondral regenerationcitations
- 2016Surface energy and stiffness discrete gradients in additive manufactured scaffolds for osteochondral regenerationcitations
- 2016Flexible Yttrium-Stabilized Zirconia Nanofibers Offer Bioactive Cues for Osteogenic Differentiation of Human Mesenchymal Stromal Cellscitations
- 2015Myoblast differentiation of human mesenchymal stem cells on graphene oxide and electrospun graphene oxide-polymer composite fibrous meshes: importance of graphene oxide conductivity and dielectric constant on their biocompatibilitycitations
- 2015Decellularized Extracellular Matrix Scaffolds for Cartilage Regenerationcitations
- 2015Distribution and Viability of Fetal and Adult Human Bone Marrow Stromal Cells in a Biaxial Rotating Vessel Bioreactor after Seeding on Polymeric 3D Additive Manufactured Scaffoldscitations
- 2014Interfacing polymeric scaffolds with primary pancreatic ductal adenocarcinoma cells to develop 3D cancer modelscitations
- 2014A biocomposite of collagen nanofibers and nanohydroxyapatite for bone regenerationcitations
- 2012Degradable amorphous scaffolds with enhanced mechanical properties and homogeneous cell distribution produced by a three‐dimensional fiber deposition methodcitations
- 2012Degradable amorphous scaffolds with enhanced mechanical properties and homogeneous cell distribution produced by a three-dimensional fiber deposition methodcitations
Places of action
Organizations | Location | People |
---|
article
Microstructured click hydrogels for cell contact guidance in 3D
Abstract
The topography of the extracellular matrix (ECM) is a major biophysical regulator of cell behavior. While this has inspired the design of cell-instructive biomaterials, the ability to present topographic cues to cells in a true 3D setting remains challenging, particularly in ECM-like hydrogels made from a single polymer. Herein, we report the design of microstructured alginate hydrogels for injectable cell delivery and show their ability to orchestrate morphogenesis via cellular contact guidance in 3D. Alginate was grafted with hydrophobic cyclooctyne groups (ALG-K), yielding amphiphilic derivatives with self-associative potential and ionic crosslinking ability. This allowed the formation of microstructured ALG-KH hydrogels, triggered by the spontaneous segregation between hydrophobic/hydrophilic regions of the polymer that generated 3D networks with stiffer microdomains within a softer lattice. The azide-reactivity of cyclooctynes also allowed ALG-K functionalization with bioactive peptides via cytocompatible strain-promoted azide-alkyne cycloaddition (SPAAC). Hydrogel-embedded mesenchymal stem cells (MSCs) were able to integrate spatial information and to mechano-sense the 3D topography, which regulated cell shape and stress fiber organization. MSCs clusters initially formed on microstructured regions could then act as seeds for neo-tissue formation, inducing cells to produce their own ECM and self-organize into multicellular structures throughout the hydrogel. By combining 3D topography, click functionalization, and injectability, using a single polymer, ALG-K hydrogels provide a unique cell delivery platform for tissue regeneration.