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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Zhang, Chunyang
European Commission
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (4/4 displayed)
- 2022Bioadhesive eutectogels supporting drug nanocrystals for long-acting delivery to mucosal tissuescitations
- 2022Microstructure and correlated mechanical properties study of Ni–(Fe, Co)–Mn–(Al, In) as-spun ribbonscitations
- 2021Microstructure and correlated mechanical properties study of Ni-(Fe, Co)-Mn-(Al, In) as-spun ribbons
- 2021Deformation of Mg-γMg17Al12 in situ composites: Room temperature mechanical behaviour, microstructures and mechanismscitations
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article
Bioadhesive eutectogels supporting drug nanocrystals for long-acting delivery to mucosal tissues
Abstract
utectogels (Egels) are an emerging class of soft ionic materials outperforming traditional temperature-intolerant hydrogels and costly ionogels. Due to their excellent elasticity, non-volatile nature, and adhesion properties, Egels are attracting a great deal of interest in the biomedical space. Herein, we report the first example of adhesive Egels loading drug nanocrystals (Egel-NCs) for controlled delivery to mucosal tissues. These soft materials were pre-pared using gelatin, glycerine, a deep eutectic solvent (DES) based on choline hydrochloride and glycerol, and nanocrystallised curcumin, a model drug with potent antimicrobial and anti-inflammatory activities. We first explored the impact of the biopolymer concentration on the viscoelastic and mechanical properties of the net-works. Thanks to the dynamic interactions between gelatin and the DES, the Egel showed excellent stretchability and elasticity (up to asymptotic to 160%), reversible gel-sol phase transition at mild temperature (asymptotic to 150 degrees C), 3D-printing ability, and good adhesion to mucin protein (stickiness asymptotic to 40 kPa). In vitro release profiles demonstrated the ability of the NCs-based Egel to deliver curcumin for up to four weeks and deposit significantly higher drug amounts in excised porcine mucosa compared to the control cohort. All in all, this study opens new prospects in designing soft adhesive materials for long-acting drug delivery and paves the way to explore novel eutectic systems with multiple therapeutic applications. ; This work was financially supported by the Wellcome Trust (UNS40040). M.B.B. received funding from Erasmus+ Traineeships for students abroad. M.L.P. has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement no. 101028881.