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Naji, M. |
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Motta, Antonella |
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Aletan, Dirar |
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Mohamed, Tarek |
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Ertürk, Emre |
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Taccardi, Nicola |
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Kononenko, Denys |
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Petrov, R. H. | Madrid |
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Alshaaer, Mazen | Brussels |
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Bih, L. |
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Casati, R. |
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Muller, Hermance |
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Kočí, Jan | Prague |
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Šuljagić, Marija |
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Kalteremidou, Kalliopi-Artemi | Brussels |
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Azam, Siraj |
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Ospanova, Alyiya |
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Blanpain, Bart |
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Ali, M. A. |
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Popa, V. |
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Rančić, M. |
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Ollier, Nadège |
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Azevedo, Nuno Monteiro |
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Landes, Michael |
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Rignanese, Gian-Marco |
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Fratila-Apachitei, Lidy
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (11/11 displayed)
- 2024On-Demand Magnetically-Activated Drug Delivery from Additively Manufactured Porous Bone Implants to Tackle Antibiotic-Resistant Infectionscitations
- 20244D printed shape-shifting biomaterials for tissue engineering and regenerative medicine applicationscitations
- 2024Bone cell response to additively manufactured 3D micro-architectures with controlled Poisson's ratiocitations
- 2023Extrusion-based 3D printing of biodegradable, osteogenic, paramagnetic, and porous FeMn-akermanite bone substitutescitations
- 2022Extrusion-based additive manufacturing of Mg-Zn alloy scaffoldscitations
- 2022Additive manufacturing of bioactive and biodegradable porous iron-akermanite composites for bone regenerationcitations
- 2022Poly(2-ethyl-2-oxazoline) coating of additively manufactured biodegradable porous ironcitations
- 2021Extrusion-based 3D printing of ex situ-alloyed highly biodegradable MRI-friendly porous iron-manganese scaffoldscitations
- 2021Extrusion-based 3D printed biodegradable porous ironcitations
- 2021Mechanical characterization of nanopillars by atomic force microscopycitations
- 2020Mechanics of bioinspired functionally graded soft-hard composites made by multi-material 3D printingcitations
Places of action
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article
Poly(2-ethyl-2-oxazoline) coating of additively manufactured biodegradable porous iron
Abstract
<p>Additively manufacturing of porous iron offers a unique opportunity to increase its biodegradation rate by taking advantage of arbitrarily complex porous structures. Nevertheless, achieving the required biodegradation profile remains challenging due to the natural passivation of iron that decrease the biodegradation rate. Moreover, the biocompatibility of iron is reported to be limited. Here, we address both challenges by applying poly(2-ethyl-2-oxazoline) coating to extrusion-based 3D printed porous iron. We characterized the specimens by performing in vitro biodegradation, electrochemical measurements, time-dependent mechanical tests, and in vitro cytocompatibility assays. The coated porous iron exhibited a biodegradation rate that was 2.6× higher than that of non-coated counterpart and maintained the bone-mimicking mechanical properties throughout biodegradation. Despite the formation of dense biodegradation products, the coating ensured a relatively stable biodegradation (i.e., 17% reduction in the degradation rate between days 14 and 28) as compared to that of non-coated specimens (i.e., 43% drop). Furthermore, the coating could be identified even after biodegradation, demonstrating the longevity of the coating. Finally, the coated specimens significantly increased the viability and supported the attachment and growth of preosteoblasts. Our results demonstrate the great potential of poly(2-ethyl-2-oxazoline) coating for addressing the multiple challenges associated with the clinical adoption of porous iron.</p>