| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Rosenholm, Jessica M.
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (13/13 displayed)
- 2023Advancement in Solubilization Approaches: A Step towards Bioavailability Enhancement of Poorly Soluble Drugscitations
- 2023Semi-solid 3D printing of mesoporous silica nanoparticle-incorporated xeno-free nanomaterial hydrogels for protein deliverycitations
- 2023Directing cellular responses in a nanocomposite 3D matrix for tissue regeneration with nanoparticle-mediated drug deliverycitations
- 2022Microfluidic-Assisted Fabrication of Dual-Coated pH-Sensitive Mesoporous Silica Nanoparticles for Protein Deliverycitations
- 2022Core@shell structured ceria@mesoporous silica nanoantibiotics restrain bacterial growth in vitro and in vivocitations
- 2021Stimuli-Responsive, Plasmonic Nanogel for Dual Delivery of Curcumin and Photothermal Therapy for Cancer Treatmentcitations
- 2020Opportunities and Challenges of Silicon‐based Nanoparticles for Drug Delivery and Imagingcitations
- 2019Nanodiamond based complexes for prolonged dexamethasone releasecitations
- 2019Brilliant blue, green, yellow, and red fluorescent diamond particles: synthesis, characterization, and multiplex imaging demonstrationscitations
- 2018Monitoring of the excretion of fluorescent nanocomposites out of the body using artificial neural networkscitations
- 2018Neural Network Classification Method for Solution of the Problem of Monitoring Theremoval of the Theranostics Nanocomposites from an Organismcitations
- 2018A method for optical imaging and monitoring of the excretion of fluorescent nanocomposites from the body using artificial neural networkscitations
- 2013Core–shell designs of photoluminescent nanodiamonds with porous silica coatings for bioimaging and drug delivery I: fabricationcitations
Places of action
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article
Core@shell structured ceria@mesoporous silica nanoantibiotics restrain bacterial growth in vitro and in vivo
Abstract
Due to its modular and flexible design options, mesoporous silica provides ample opportunities when developing new strategies for combinatory antibacterial treatments. In this study, antibacterial ceria (CeO2) nanoparticles (NP) were used as core material, and were further coated with a mesoporous silica shell (mSiO2) to obtain a core@shell structured nanocomposite (CeO2@mSiO2). The porous silica shell was utilized as drug reservoir, whereby CeO2@mSiO2 was loaded with the antimicrobial agent capsaicin (CeO2@mSiO2/Cap). CeO2@mSiO2/Cap was further surface-coated with the natural antimicrobial polymer chitosan by employing physical adsorption. The obtained nanocomposite, CeO2@mSiO2/Cap@Chit, denoted NAB, which stands for “nanoantibiotic”, provided a combinatory antibacterial mode of action. The antibacterial effect of NAB on the Gram-negative bacteria Escherichia coli was proven to be significant in vitro. In addition, in vivo evaluations revealed NAB to inhibit the bacterial growth in the intestine of bacteria-fed Drosophila melanogaster larvae, and decreased the required dose of capsaicin needed to eliminate bacteria. As our constructed CeO2@mSiO2 did not show toxicity to mammalian cells, it holds promise for the development of next-generation nanoantibiotics of non-toxic nature with flexible design options.