| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Dolatshahi-Pirouz, Alireza
Technical University of Denmark
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (19/19 displayed)
- 2024Engineering Photo-Cross-Linkable MXene-Based Hydrogels:Durable Conductive Biomaterials for Electroactive Tissues and Interfacescitations
- 2024Engineering Photo-Cross-Linkable MXene-Based Hydrogels: Durable Conductive Biomaterials for Electroactive Tissues and Interfacescitations
- 2023Multi-leveled Nanosilicate Implants Can Facilitate Near-Perfect Bone Healingcitations
- 2023Composite Graded Melt Electrowritten Scaffolds for Regeneration of the Periodontal Ligament-to-Bone Interfacecitations
- 2022Bioinspired gelatin/bioceramic composites loaded with bone morphogenetic protein-2 (BMP-2) promote osteoporotic bone repaircitations
- 2021Design and construction of a novel measurement device for mechanical characterization of hydrogelscitations
- 2021Design and construction of a novel measurement device for mechanical characterization of hydrogels:A case studycitations
- 2021Combinatorial fluorapatite-based scaffolds substituted with strontium, magnesium and silicon ions for mending bone defectscitations
- 2021Rheological characterization of 3D printable geopolymerscitations
- 20193D-printed bioactive scaffolds from nanosilicates and PEOT/PBT for bone tissue engineeringcitations
- 20193D-printed bioactive scaffolds from nanosilicates and PEOT/PBT for bone tissue engineeringcitations
- 2019Self-Healing Hydrogels: The Next Paradigm Shift in Tissue Engineering?citations
- 2019Silica nanoparticle surface chemistry: An important trait affecting cellular biocompatibility in two and three dimensional culture systemscitations
- 2019Combating Microbial Contamination with Robust Polymeric Nanofibers: Elemental Effect on the Mussel-Inspired Cross-Linking of Electrospun Gelatincitations
- 2017Nanoreinforced Hydrogels for Tissue Engineering: Biomaterials that are Compatible with Load-Bearing and Electroactive Tissuescitations
- 2017Nanoreinforced hydrogels for tissue engineering:Biomaterials that are compatible with load-bearing and electroactive tissuescitations
- 2016Injectable shear-thinning nanoengineered hydrogels for stem cell deliverycitations
- 2011Growth characteristics of inclined columns produced by Glancing Angle Deposition (GLAD) and colloidal lithographycitations
- 2010Synthesis of functional nanomaterials via colloidal mask templating and glancing angle deposition (GLAD)”
Places of action
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article
Bioinspired gelatin/bioceramic composites loaded with bone morphogenetic protein-2 (BMP-2) promote osteoporotic bone repair
Abstract
<p>There are currently several commercialized products approved by the Food and Drug Administration and the European Medicines Agency based on the use of recombinant human BMP-2 for the treatment of non-unions long fractures and spinal fusion. However, the adverse effects recorded with the use of BMPs suggest the need for drug delivery carriers that allow reducing the required doses and improve their cost-effectiveness. Herein, we have developed a new osteoconductive scaffold that reduces the required doses of BMP-2 for promoting bone regeneration in an osteoporotic defect model. The composite is, in brief, a gelatin-based 3D scaffold reinforced with either calcium sulfate or hydroxyapatite as an inorganic osteoconductive biomaterial. To this end, the organic/inorganic composite systems showed high hydration capacity and good in vitro degradability. The incorporation of 7.5% (m/v) ceramic compounds resulted in scaffolds with stiffer Young modulus (179 and 75 kPa for CaSO<sub>4</sub>_7 and HA_7, respectively) than bare gelatin hydrogels (48 kPa). Studies with human bone-marrow derived mesenchymal stem cells (hBM-MSCs) revealed that the 3D scaffolds promote cell adhesion and proliferation along with osteogenic differentiation capabilities. Specifically, downregulation of stemness (Nanog, Oct4) genes and upregulation of osteogenic markers (ALP, Col1a1, Fmod) by two fold were observed over 10 days under basal culture conditions. Promisingly, the sustained in vitro release of BMP-2 observed from the porous reinforced scaffolds allowed us to address the critical-sized osteoporotic mice calvarial defects with a relatively low growth factor doses (600 ng BMP-2/scaffold) compared to conventional doses at 2–15 micrograms. Overall, this study demonstrates the promising potential of osteoconductive gelatin/calcium bioceramics composites as osteogenic growth factors delivery carriers for bone-regeneration via ultra-low growth factor doses.</p>