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Naji, M. |
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Motta, Antonella |
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Aletan, Dirar |
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Mohamed, Tarek |
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Ertürk, Emre |
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Taccardi, Nicola |
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Kononenko, Denys |
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Petrov, R. H. | Madrid |
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Alshaaer, Mazen | Brussels |
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Bih, L. |
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Casati, R. |
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Muller, Hermance |
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Kočí, Jan | Prague |
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Šuljagić, Marija |
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Kalteremidou, Kalliopi-Artemi | Brussels |
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Azam, Siraj |
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Ospanova, Alyiya |
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Blanpain, Bart |
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Ali, M. A. |
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Popa, V. |
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Rančić, M. |
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Ollier, Nadège |
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Azevedo, Nuno Monteiro |
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Landes, Michael |
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Rignanese, Gian-Marco |
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Fawzy, Amr
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (23/23 displayed)
- 2024Effect of inositol hexaphosphate acid versus polyacrylic acid on dentin properties and adhesion of a self-adhesive restorative material to dentincitations
- 2024The Synergistic Effect of High Intensity Focused Ultrasound on In-vitro Remineralization of Tooth Enamel by Calcium Phosphate Ion Clusterscitations
- 2024Flowable resin-based composites modified with chlorhexidine-loaded mesoporous silica nanoparticles induce superior antibiofilm properties
- 2022Cytotoxicity and antimicrobial efficiency of ZrO2 nanoparticles reinforced 3D printed resinscitations
- 2022Development of 3D printed dental resin nanocomposite with graphene nanoplatelets enhanced mechanical properties and induced drug-free antimicrobial activity.citations
- 2021Development of 3D printed resin reinforced with modified ZrO2 nanoparticles for long-term provisional dental restorationscitations
- 2021Formulation of pH-sensitive chlorhexidine-loaded/mesoporous silica nanoparticles modified experimental dentin adhesivecitations
- 2020The Effect of Cross-linking Efficiency of Drug-Loaded Novel Freeze Gelated Chitosan Templates for Periodontal Tissue Regenerationcitations
- 2020Effect of acid etching on dentin bond strength of ultra-mild self-etch adhesivescitations
- 2020Properties of a modified quaternary ammonium silane formulation as a potential root canal irrigant in endodonticscitations
- 2020In vitro bonding performance of modern self-adhesive resin cements and conventional resin-modified glass ionomer cements to prosthetic substratescitations
- 2019Resin-based dental composites for tooth filling
- 2019Macrophage response and surface analysis of dental cementum after treatment with high intensity focused ultrasoundcitations
- 2019An in vitro study of a novel quaternary ammonium silane endodontic irrigantcitations
- 2019Co-blend application mode of bulk fill composite resincitations
- 2018In vitro assessment of ribose modified two-step etch-and-rinse dentine adhesivecitations
- 2017Proanthocyanidins-Loaded Nanoparticles Enhance Dentin Degradation Resistancecitations
- 2017Potentiating the antibacterial effect of silver nanospheres by surface-capping with chlorhexidine gluconatecitations
- 2015Characterization of antibacterial and adhesion properties of chitosan-modified glass ionomer cementcitations
- 2012Riboflavin as a dentin crosslinking agentcitations
- 2009Effect acidic and alkaline/heat treatments on the bond strength of different luting cements to commercially pure titaniumcitations
- 2009Tensile bond strength of immediately repaired anterior microfine hybrid restorative composite using nontrimmed hourglass specimens
- 2008Effect of surface treatments on the tensile bond strength of repaired water-aged anterior restorative micro-fine hybrid resin compositecitations
Places of action
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article
Formulation of pH-sensitive chlorhexidine-loaded/mesoporous silica nanoparticles modified experimental dentin adhesive
Abstract
<p>We formulated a pH-sensitive chlorhexidine-loaded mesoporous silica nanoparticles (MSN) modified with poly-(lactic-co-glycolic acid) (CHX-loaded/MSN-PLGA) and incorporated into experimental resin-based dentin adhesives at 5 and 10 wt%. Nanocarriers were characterized in terms of morphology, physicochemical features, spectral analyses, drug-release kinetics at varying pH and its effect on dentin-bound proteases was investigated. The modified dentin adhesives were characterized for cytotoxicity, antimicrobial activity, degree of conversion (DC) along with CHX release, micro-tensile bond strength (μTBS) and nano-leakage expression were studied at different pH values and storage time. CHX-loaded/MSN-PLGA nanocarriers exhibited a significant pH-dependent drug release behavior than CHX-loaded/MSN nanocarriers without PLGA modification. The highest percentage of CHX release was seen with 10 wt% CHX-loaded/MSN-PLGA doped adhesive at a pH of 5.0. CHX-loaded/MSN-PLGA modified adhesives exhibited more profound antibiofilm characteristics against S. mutans and more sustained CHX-release which was pH dependent. After 6 months in artificial saliva at varying pH, the 5 wt% CHX-loaded/MSN-PLGA doped adhesive showed excellent bonding under SEM/TEM, higher μTBS, and least nano-leakage expression. The pH-sensitive CHX-loaded/MSN-PLGA could be of crucial advantage for resin-dentin bonding applications especially in reduced pH microenvironment resulting from biofilm formation; and the activation of dentin-bound proteases as a consequence of acid etching and acidic content of bonding resin monomers.</p>