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Naji, M. |
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Motta, Antonella |
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Aletan, Dirar |
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Mohamed, Tarek |
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Ertürk, Emre |
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Taccardi, Nicola |
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Kononenko, Denys |
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Petrov, R. H. | Madrid |
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Alshaaer, Mazen | Brussels |
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Bih, L. |
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Casati, R. |
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Muller, Hermance |
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Kočí, Jan | Prague |
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Šuljagić, Marija |
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Kalteremidou, Kalliopi-Artemi | Brussels |
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Azam, Siraj |
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Ospanova, Alyiya |
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Blanpain, Bart |
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Ali, M. A. |
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Popa, V. |
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Rančić, M. |
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Ollier, Nadège |
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Azevedo, Nuno Monteiro |
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Landes, Michael |
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Rignanese, Gian-Marco |
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Massera, J.
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (27/27 displayed)
- 2024Biophotonic composite scaffolds for controlled nitric oxide release upon NIR excitation
- 2024Crystallization mechanism of B12.5 bioactive borosilicate glasses and its impact on in vitro degradationcitations
- 2023Crystallization mechanism of B12.5 bioactive borosilicate glasses and its impact on in vitro degradationcitations
- 2023Chemical interactions in composites of gellan gum and bioactive glass: self-crosslinking and in vitro dissolutioncitations
- 2023New Mg/Sr phosphate bioresorbable glass system with enhanced sintering propertiescitations
- 2022Influence of Phosphate on Network Connectivity and Glass Transition in Highly Polymerized Aluminosilicate Glassescitations
- 2022Specific trends in phosphate glass crystallizationcitations
- 2022Robocasting of multicomponent sol-gel–derived silicate bioactive glass scaffolds for bone tissue engineeringcitations
- 2021Surface Modification of Bioresorbable Phosphate Glasses for Controlled Protein Adsorptioncitations
- 2021Nano-imaging confirms improved apatite precipitation for high phosphate/silicate ratio bioactive glassescitations
- 2021Specific trends in phosphate glass crystallizationcitations
- 2021Specific trends in phosphate glass crystallizationcitations
- 2020Nucleation and growth behavior of Er3+doped oxyfluorophosphate glassescitations
- 2020Dissolution, bioactivity and osteogenic properties of composites based on polymer and silicate or borosilicate bioactive glasscitations
- 2020Phosphate/oxyfluorophosphate glass crystallization and its impact on dissolution and cytotoxicitycitations
- 2019Core-clad phosphate glass fibers for biosensingcitations
- 2019Fabrication and characterization of new phosphate glasses and glass-ceramics suitable for drawing optical and biophotonic fibers
- 2018In vitro Evaluation of Porous borosilicate, borophosphate and phosphate Bioactive Glasses Scaffolds fabricated using Foaming Agent for Bone Regenerationcitations
- 2018Processing and Characterization of Bioactive Borosilicate Glasses and Scaffolds with Persistent Luminescencecitations
- 2018Persistent luminescent particles containing bioactive glassescitations
- 2018Luminescence of Er3+ doped oxyfluoride phosphate glasses and glass-ceramicscitations
- 2017Crystallization and sintering of borosilicate bioactive glasses for application in tissue engineeringcitations
- 2017Thermal, structural and in vitro dissolution of antimicrobial copper-doped and slow resorbable iron-doped phosphate glassescitations
- 2016Novel oxyfluorophosphate glasses and glass-ceramicscitations
- 2016Effect of the glass melting condition on the processing of phosphate-based glass-ceramics with persistent luminescence propertiescitations
- 2016Thermal, structural and optical properties of Er3+ doped phosphate glasses containing silver nanoparticlescitations
- 2015Processing and characterization of phosphate glasses containing CaAl2O4:Eu2+,Nd3+ and SrAl2O4:Eu2+,Dy3+ microparticlescitations
Places of action
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article
Dissolution, bioactivity and osteogenic properties of composites based on polymer and silicate or borosilicate bioactive glass
Abstract
<p>Bioactive glass (BAG)/Poly (Lactic Acid) (PLA) composites have great potential for bone tissue engineering. The interest in these materials is to obtain a scaffold with tailorable properties bringing together the advantages of the composites’ constituents such as the biodegradability, bioactivity and osteoinduction. The materials studied are PLA/13–93 and PLA/13-93B20 (20% of SiO<sub>2</sub> is replaced with B<sub>2</sub>O<sub>3</sub> in the 13–93 composition). To characterize them, they were dissolved in TRIS buffer and Simulated Body Fluid (SBF) in vitro. Over the 10 weeks of immersion in TRIS, the ion release from the composites was constant. Following immersion in SBF for 2 weeks, the hydroxyapatite (HA) layer was found to precipitate at the composites surface. By adding Boron, both these reactions were accelerated, as the borosilicate glass dissolves faster than pure silicate glass alone. Polymer degradation was studied and showed that during immersion, the pure PLA rods maintained their molecular weight whereby the composites decreased with time, but despite this the mechanical properties remained stable for at least 10 weeks. Their ability to induce osteogenic differentiation of myoblastic cells was also demonstrated with cell experiments showing that C2C12 cells were able to proliferate and spread on the composites. The Myosin Heavy Chain and Osteopontin were tracked by immunostaining the cells and showed a suppression of the myosin signal and the presence of osteopontin, when seeded onto the composites. This proves osteoinduction occurred. In studying the mineralization of the cells, it was found that BAG presence conditions the synthesizing of mineral matter in the cells. The results show that these composites have a potential for bone tissue engineering.</p>