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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Lyyra, Inari
Tampere University
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (7/7 displayed)
- 2024Composition and Properties of Biodegradable Composites of a Bioactive Glass Filler and a Single Polymer or a Blend Matrix
- 2023Interpretable machine learning methods for monitoring polymer degradation in extrusion of polylactic acidcitations
- 2023Hydrolytic degradation of polylactide/polybutylene succinate blends with bioactive glasscitations
- 2021Impact of glass composition on hydrolytic degradation of polylactide/bioactive glass compositescitations
- 2020Dissolution, bioactivity and osteogenic properties of composites based on polymer and silicate or borosilicate bioactive glasscitations
- 2018Bioresorbable Conductive Wire with Minimal Metal Contentcitations
- 2015Optimising polylactide melt spinning using real-time monitoring
Places of action
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article
Dissolution, bioactivity and osteogenic properties of composites based on polymer and silicate or borosilicate bioactive glass
Abstract
<p>Bioactive glass (BAG)/Poly (Lactic Acid) (PLA) composites have great potential for bone tissue engineering. The interest in these materials is to obtain a scaffold with tailorable properties bringing together the advantages of the composites’ constituents such as the biodegradability, bioactivity and osteoinduction. The materials studied are PLA/13–93 and PLA/13-93B20 (20% of SiO<sub>2</sub> is replaced with B<sub>2</sub>O<sub>3</sub> in the 13–93 composition). To characterize them, they were dissolved in TRIS buffer and Simulated Body Fluid (SBF) in vitro. Over the 10 weeks of immersion in TRIS, the ion release from the composites was constant. Following immersion in SBF for 2 weeks, the hydroxyapatite (HA) layer was found to precipitate at the composites surface. By adding Boron, both these reactions were accelerated, as the borosilicate glass dissolves faster than pure silicate glass alone. Polymer degradation was studied and showed that during immersion, the pure PLA rods maintained their molecular weight whereby the composites decreased with time, but despite this the mechanical properties remained stable for at least 10 weeks. Their ability to induce osteogenic differentiation of myoblastic cells was also demonstrated with cell experiments showing that C2C12 cells were able to proliferate and spread on the composites. The Myosin Heavy Chain and Osteopontin were tracked by immunostaining the cells and showed a suppression of the myosin signal and the presence of osteopontin, when seeded onto the composites. This proves osteoinduction occurred. In studying the mineralization of the cells, it was found that BAG presence conditions the synthesizing of mineral matter in the cells. The results show that these composites have a potential for bone tissue engineering.</p>