| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Silva, Jorge Carvalho
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (21/21 displayed)
- 2024Preparation and Characterization of Zinc Ferrite and Gadolinium Iron Garnet Composite for Biomagnetic Applicationscitations
- 2024Cryoprotective Polysaccharides with Ordered Gel Structures Induce Ice Growth Anticipation and Survival Enhancement during Cell Cryopreservationcitations
- 2024Bioactive Hydroxyapatite Aerogels with Piezoelectric Particlescitations
- 2023Biocomposite Macrospheres Based on Strontium-Bioactive Glass for Application as Bone Fillerscitations
- 2023Thermal, Structural, Morphological and Electrical Characterization of Cerium-Containing 45S5 for Metal Implant Coatingscitations
- 2023Extensive Investigation on the Effect of Niobium Insertion on the Physical and Biological Properties of 45S5 Bioactive Glass for Dental Implantcitations
- 2023Extensive Investigation on the Effect of Niobium Insertion on the Physical and Biological Properties of 45S5 Bioactive Glass for Dental Implantcitations
- 2023Bioactive Glass Modified with Zirconium Incorporation for Dental Implant Applications ; Fabrication, Structural, Electrical, and Biological Analysiscitations
- 2023Hydroxyapatite-Barium Titanate Biocoatings Using Room Temperature Coblastingcitations
- 2023Bioactive Glass Modified with Zirconium Incorporation for Dental Implant Applicationscitations
- 2022Characterization of a Biocomposite of Electrospun PVDF Membranes with Embedded BaTiO3 Micro- and Nanoparticlescitations
- 2019Using water to control electrospun Polycaprolactone fibre morphology for soft tissue engineeringcitations
- 2019Electrospun biodegradable chitosan based-poly(urethane urea) scaffolds for soft tissue engineeringcitations
- 2019Polymer blending or fiber blending: a comparative study using chitosan and poly(ε-caprolactone) electrospun fiberscitations
- 2018Synthesis, electrospinning and in vitro test of a new biodegradable gelatin-based poly(ester urethane urea) for soft tissue engineeringcitations
- 2017Evaluation of nanofibrous scaffolds obtained from blends of chitosan, gelatin and polycaprolactone for skin tissue engineeringcitations
- 2017Hybrid polysaccharide-based systems for biomedical applicationscitations
- 2016Natural Nanofibres for Composite Applicationscitations
- 2016A simple sol-gel route to the construction of hydroxyapatite inverted colloidal crystals for bone tissue engineeringcitations
- 2015Osteogenisis enhancement of hydroxyapatite based materials by electrical polarization
- 2014Electrical polarization of a chitosan-hydroxyapatite composite
Places of action
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article
Electrospun biodegradable chitosan based-poly(urethane urea) scaffolds for soft tissue engineering
Abstract
<p>The composition and architecture of a scaffold determine its supportive role in tissue regeneration. In this work, we demonstrate the feasibility of obtaining a porous electrospun fibrous structure from biodegradable polyurethanes (Pus) synthesized using polycaprolactone-diol as soft segment and, as chain extenders, chitosan (CS) and/or dimethylol propionic acid. Fourier transform infrared spectroscopy and proton nuclear magnetic resonance confirmed the syntheses. Fibre mats' properties were analysed and compared with those of solvent cast films. Scanning electron microscopy images of the electrospun scaffolds revealed fibres with diameters around 1 μm. From tensile tests, we found that Young's modulus increases with CS content and is higher for films (2.5 MPa to 6.5 MPa) than for the corresponding fibre mats (0.8 MPa to 3.2 MPa). The use of CS as the only chain extender improves recovery ratio and resilience. From X-ray diffraction, a higher crystalline degree was identified in fibre mats than in the corresponding films. Films' wettability was enhanced by the presence of CS as shown by the decrease of water contact angle. X-ray photoelectron spectroscopy revealed that while ester groups are predominant at the films' surface, ester and urethanes are present in similar concentrations at fibres' surface, favouring the interaction with water molecules. Both films and fibres undergo hydrolytic degradation. In vitro evaluation was performed with human dermal fibroblasts. No PU sample revealed cytotoxicity. Cells adhered to fibre mats better than to films and proliferation was observed only for samples of CS-containing PUs. Results suggest that electrospun fibres of CS-based polyurethanes are good candidate scaffolds for soft tissue engineering.</p>