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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Zhou, Zuoxin
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (8/8 displayed)
- 2021An imidazolium-based supramolecular gelator enhancing interlayer adhesion in 3D printed dual network hydrogelscitations
- 2021Bespoke 3D-Printed Polydrug Implants Created via Microstructural Control of Oligomerscitations
- 2021Bespoke 3D-Printed Polydrug Implants Created via Microstructural Control of Oligomerscitations
- 2020Binder jetting additive manufacturing of hydroxyapatite powders: Effects of adhesives on geometrical accuracy and green compressive strengthcitations
- 20193D and 4D printing of biomaterials and biocomposites, bioinspired composites, and related transformerscitations
- 2018Development of three-dimensional printing polymer-ceramic scaffolds with enhanced compressive properties and tuneable resorptioncitations
- 2017Inkjet-printed polyvinyl alcohol multilayerscitations
- 2016Development of a direct feed fused deposition modelling technology for multi-material manufacturing
Places of action
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article
Development of three-dimensional printing polymer-ceramic scaffolds with enhanced compressive properties and tuneable resorption
Abstract
In this study, bone tissue engineered scaffolds fabricated via powder-based 3D printing from hydroxyapatite (HA) and calcium sulphate (CaSO 4 ) powders were investigated. The combination of using a fast resorbing CaSO 4 based powder and the relatively slower HA powder represents a promising prospect for tuning the bioresorption of 3D printed (3DP) scaffolds. These properties could then be tailored to coincide with tissue growth rate for different surgical procedures. The manufactured scaffolds were infiltrated with poly(ε‑caprolactone) (PCL). The PCL infiltrated the inter-particle spacing within the 3DP structures due to the nature of a loosely-packed powder bed and also covered the surface of ceramic-based scaffolds. Consequently, the average compressive strength, compressive modulus and toughness increased by 314%, 465% and 867%, respectively. The resorption behaviour of the 3DP scaffolds was characterised in vitro using a high-throughput system that mimicked the physiological environment and dynamic flow conditions relevant to the human body. A rapid release of CaSO 4 between Day 0 and 28 was commensurate with a reduction in scaffold mass and compressive properties, as well as an increase in medium absorption. In spite of this, HA particles, connected by PCL fibrils, remained within the microstructure after 56 days resorption under dynamic conditions. Consequently, a high level of structural integrity was maintained within the 3DP scaffold. This study presented a porous PCL-HA-CaSO 4 3DP structure with the potential to encourage new tissue growth during the initial stages of implantation and also offering sufficient structural and mechanical support during the bone healing phase.