| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Ribeiro, Clarisse
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (32/32 displayed)
- 2023Development of Silk Fibroin Scaffolds for Vascular Repaircitations
- 2023Natural Indigenous Paper Substrates for Colorimetric Bioassays in Portable Analytical Systems: Sustainable Solutions from the Rain Forests to the Great Plainscitations
- 2023Graphene Based Printable Conductive Wax for Low‐Power Thermal Actuation in Microfluidic Paper‐Based Analytical Devicescitations
- 2023Enhanced neuronal differentiation by dynamic piezoelectric stimulationcitations
- 2022Electrospun Magnetic Ionic Liquid Based Electroactive Materials for Tissue Engineering Applicationscitations
- 2022Piezoelectric and Magnetically Responsive Biodegradable Composites with Tailored Porous Morphology for Biotechnological Applicationscitations
- 2022Environmentally friendly conductive screen‐printable inks based on N‐Doped graphene and polyvinylpyrrolidonecitations
- 2022Understanding Myoblast Differentiation Pathways When Cultured on Electroactive Scaffolds through Proteomic Analysiscitations
- 2022Printed multifunctional magnetically activated energy harvester with sensing capabilitiescitations
- 2022Tuning magnetic response and ionic conductivity of electrospun hybrid membranes for tissue regeneration strategiescitations
- 2021Ionic Liquid-Based Materials for Biomedical Applicationscitations
- 2020Patterned Piezoelectric Scaffolds for Osteogenic Differentiationcitations
- 2020Morphology dependence degradation of electro-and magnetoactive poly(3-hydroxybutyrateco-hydroxyvalerate) for tissue engineering applicationscitations
- 2020Silica nanoparticles surface charge modulation of the electroactive phase content and physical-chemical properties of poly(vinylidene fluoride) nanocompositescitations
- 2020Magnetic Bioreactor for Magneto-, Mechano- and Electroactive Tissue Engineering Strategiescitations
- 2020Biodegradable Hydrogels Loaded with Magnetically Responsive Microspheres as 2D and 3D Scaffoldscitations
- 2020Morphology Dependence Degradation of Electro- and Magnetoactive Poly(3-hydroxybutyrate-co-hydroxyvalerate) for Tissue Engineering Applicationscitations
- 2019Development of bio-hybrid piezoresistive nanocomposites using silk-elastin protein copolymerscitations
- 2019Ionic-liquid-based electroactive polymer composites for muscle tissue engineeringcitations
- 2018Tailored biodegradable and electroactive poly(hydroxybutyrate-co-hydroxyvalerate) based morphologies for tissue engineering applicationscitations
- 2018Electroactive poly(vinylidene fluoride)-based structures for advanced applicationscitations
- 2018Multifunctional platform based on electroactive polymers and silica nanoparticles for tissue engineering applicationscitations
- 2018Silk fibroin-magnetic hybrid composite electrospun fibers for tissue engineering applicationscitations
- 2018Electroactive biomaterial surface engineering effects on muscle cells differentiationcitations
- 2018Relation between fiber orientation and mechanical properties of nano-engineered poly(vinylidene fluoride) electrospun composite fiber matscitations
- 2018Fluorinated polymers as smart materials for advanced biomedical applicationscitations
- 2018Tailored Biodegradable and Electroactive Poly(Hydroxybutyrate-Co-Hydroxyvalerate) Based Morphologies for Tissue Engineering Applicationscitations
- 2017Nanodiamonds/poly(vinylidene fluoride) composites for tissue engineering applicationscitations
- 2016Electromechanical actuators based on poly(vinylidene fluoride) with [N1 1 1 2(OH)][NTf2] and [C2mim] [C2SO4]citations
- 2016Development of poly(vinylidene fluoride)/ionic liquid electrospun fibers for tissue engineering applicationscitations
- 2015Influence of oxygen plasma treatment parameters on poly(vinylidene fluoride) electrospun fiber mats wettabilitycitations
- 2015Piezoelectric polymers as biomaterials for tissue engineering applicationscitations
Places of action
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article
Electroactive biomaterial surface engineering effects on muscle cells differentiation
Abstract
Even though skeletal muscle cells can naturally regenerate as a response to insignificant tissue damages, more severe injuries can cause irreversible loss of muscle cells mass and/or function. Until now, cell therapies are not a good approach to treat those injuries. Biomaterials such as poly(vinylidene fluoride), PVDF, can improve muscle regeneration by presenting physical cues to muscle cells that mimic the natural regeneration environment. In this way, the ferroelectric and piezoelectric properties of PVDF offer new opportunities for skeletal muscle tissue engineering once the piezoelectricity is an electromechanical effect that can be used to provide electrical signals to the cells, upon mechanical solicitations, similar to the ones found in several body tissues. Thus, previous to dynamic experiments, it is important to determine how the surface properties of the material, both in terms of the poling state (positive or negative net surface charge) and of the morphology (films or fibers) influence myoblast differentiation. It was observed that PVDF promotes myogenic differentiation of C2C12 cells as evidenced by quantitative analysis of myotube fusion, maturation index, length, diameter and number. Charged surfaces improve the fusion of muscle cells into differentiated myotubes, as demonstrated by fusion and maturation index values higher than the control samples. Finally, the use of random and oriented -PVDF electrospun fibers scaffolds has revealed differences in cell morphology. Contrary to the randomly oriented fibers, oriented PVDF electrospun fibers have promoted the alignment of the cells. It is thus demonstrated that the use of this electroactive polymer represents a suitable approach for the development of electroactive microenvironments for effective muscle tissue engineering. ; Thiswork was supported by thePortuguese Science and Technology Foundation (FCT) in the framework of the Strategic Funding UID/FIS/ 04650/2013 and UID/BIA/04050/2013 (POCI-01-0145-FEDER007569) and project ...