| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Gelinsky, Michael
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (35/35 displayed)
- 2024Poly(dl-lactide) Polymer Blended with Mineral Phases for Extrusion 3D Printing—Studies on Degradation and Biocompatibilitycitations
- 20243D bioprinting of mouse pre-osteoblasts and human MSCs using bioinks consisting of gelatin and decellularized bone particlescitations
- 2024Gelatin Methacryloyl (GelMA) - 45S5 Bioactive Glass (BG) Composites for Bone Tissue Engineering: 3D Extrusion Printability and Cytocompatibility Assessment Using Human Osteoblastscitations
- 2023Advanced Polymeric Membranes as Biomaterials Based on Marine Sources Envisaging the Regeneration of Human Tissuescitations
- 2023Mesoporous Bioactive Glass-Incorporated Injectable Strontium-Containing Calcium Phosphate Cement Enhanced Osteoconductivity in a Critical-Sized Metaphyseal Defect in Osteoporotic Ratscitations
- 2022Oxygen-sensitive nanoparticles reveal the spatiotemporal dynamics of oxygen reduction during magnesium implant biodegradationcitations
- 2022Quantification of calcium content in bone by using ToF-SIMS-a first approach
- 2022Think outside the boxcitations
- 20223D Extrusion Printing of Biphasic Anthropomorphic Brain Phantoms Mimicking MR Relaxation Times Based on Alginate-Agarose-Carrageenan Blendscitations
- 2020New insights into ToF-SIMS imaging in osteoporotic bone researchcitations
- 2020Catechol Containing Polyelectrolyte Complex Nanoparticles as Local Drug Delivery System for Bortezomib at Bone Substitute Materialscitations
- 2020Electrodeposition of Sr-substituted hydroxyapatite on low modulus beta-type Ti-45Nb and effect on in vitro Sr release and cell responsecitations
- 2019Investigation of strontium transport and strontium quantification in cortical rat bone by time-of-flight secondary ion mass spectrometrycitations
- 2019Influence of cobalt chromium alloy surface modification on the roughness and wettability behavior of pine oil/hydroxyapatite as coatingcitations
- 2019Recapitulating bone development events in a customised bioreactor through interplay of oxygen tension, medium pH, and systematic differentiation approachescitations
- 2019Investigating the effect of sterilisation methods on the physical properties and cytocompatibility of methyl cellulose used in combination with alginate for 3D-bioplotting of chondrocytescitations
- 2019Investigating the effect of sterilisation methods on the physical properties and cytocompatibility of methyl cellulose used in combination with alginate for 3D-bioplotting of chondrocytescitations
- 2019Development and Characterization of Composites Consisting of Calcium Phosphate Cements and Mesoporous Bioactive Glass for Extrusion-Based Fabricationcitations
- 2019Electrodeposition of Sr-substituted hydroxyapatite on low modulus beta-type Ti-45Nb and effect on in vitro Sr release and cell response
- 2018S and B microalloying of biodegradable Fe-30Mn-1C - Effects on microstructure, tensile properties, in vitro degradation and cytotoxicitycitations
- 2018Influence of Regioselectively Sulfated Cellulose on in Vitro Vascularization of Biomimetic Bone Matricescitations
- 2018Factors affecting the mechanical and geometrical properties of electrostatically flocked pure chitosan fiber scaffoldscitations
- 2018Strontium-modification of porous scaffolds from mineralized collagen for potential use in bone defect therapycitations
- 2018Influence of deformation on the structure and mechanical properties of a titanium-based alloy obtained by self-propagating high temperature synthesis
- 2017Strontium release from Sr2+-loaded bone cements and dispersion in healthy and osteoporotic rat bonecitations
- 2017Development of novel titanium-based surfaces using plasma- and ion beam technologies
- 2017Heparin modification of a biomimetic bone matrix modulates osteogenic and angiogenic cell response in vitrocitations
- 2017Intrinsic 3D prestressingcitations
- 2017Developing a Customized Perfusion Bioreactor Prototype with Controlled Positional Variability in Oxygen Partial Pressure for Bone and Cartilage Tissue Engineeringcitations
- 2016Low temperature additive manufacturing of three dimensional scaffolds for bone-tissue engineering applicationscitations
- 2013Quantification of calcium content in bone by using ToF-SIMS–a first approach
- 2013Heparin modification of a biomimetic bone matrix for controlled release of VEGFcitations
- 2011Bioactive SrO-SiO<sub>2</sub> glass with well-ordered mesopores: Characterization, physiochemistry and biological propertiescitations
- 2010Stem Cell Engineering for Regeneration of Bone Tissuecitations
- 2006O-Phospho-L-serine modified calcium phosphate cements - material properties, in vitro and in vivo investigationscitations
Places of action
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article
Strontium-modification of porous scaffolds from mineralized collagen for potential use in bone defect therapy
Abstract
<p>The present study describes the development and characterization of strontium(II)-modified biomimetic scaffolds based on mineralized collagen type I as potential biomaterial for the local treatment of defects in systemically impaired (e.g. osteoporotic) bone. In contrast to already described collagen/hydroxyapatite nanocomposites calcium was substituted with strontium to the extent of 25, 50, 75 and 100mol% by substituting the CaCl2-stock solution (0.1M) with SrCl2 (0.1M) during the scaffold synthesis. Simultaneous fibrillation and mineralization of collagen led to the formation of collagen-mineral nanocomposites with mineral phases shifting from nanocrystalline hydroxyapatite (Sr0) over poorly crystalline Sr-rich phases towards a mixed mineral phase (Sr100), consisting of an amorphous strontium phosphate (identified as Collin's salt, Sr6H3(PO4)5∗2 H2O, CS) and highly crystalline strontium hydroxyapatite (Sr5(PO4)3OH, SrHA). The formed mineral phases were characterized by transmission electron microscopy (TEM) and RAMAN spectroscopy. All collagen/mineral nanocomposites with graded strontium content were processed to scaffolds exhibiting an interconnected porosity suitable for homogenous cell seeding in vitro. Strontium ions (Sr2+) were released in a sustained manner from the modified scaffolds, with a clear correlation between the released Sr2+ concentration and the degree of Sr-substitution. The accumulated specific Sr2+ release over the course of 28days reached 141.2μg (~27μgmg-1) from Sr50 and 266.1μg (~35μgmg-1) from Sr100, respectively. Under cell culture conditions this led to maximum Sr2+ concentrations of 0.41mM (Sr50) and 0.73mM (Sr100) measured on day 1, which declined to 0.08mM and 0.16mM, respectively, at day 28. Since Sr2+ concentrations in this range are known to have an osteo-anabolic effect, these scaffolds are promising biomaterials for the clinical treatment of defects in systemically impaired bone.</p>