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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Hassanin, Hany
Canterbury Christ Church University
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (19/19 displayed)
- 2023Hot Air Contactless Single Point Incremental Formingcitations
- 2022Multipoint Forming Using Hole-Type Rubber Punchcitations
- 2021Laser powder bed fusion of Ti-6Al-2Sn-4Zr-6Mo alloy and properties prediction using deep learning approachescitations
- 2020Controlling the properties of additively manufactured cellular structures using machine learning approachescitations
- 20204D printing of origami structures for minimally invasive surgeries using functional scaffoldcitations
- 2018Additive Manufactured Sandwich Composite/ABS Parts for Unmanned Aerial Vehicle Applicationscitations
- 2018Surface finish improvement of additive manufactured metal partscitations
- 2018Microfabrication of Net Shape Zirconia/Alumina Nano-Composite Micro Partscitations
- 2018Tailoring selective laser melting process for titanium drug-delivering implants with releasing micro-channelscitations
- 2018Porosity control in 316L stainless steel using cold and hot isostatic pressingcitations
- 2017Net-Shape Manufacturing using Hybrid Selective Laser Melting/Hot Isostatic Pressingcitations
- 2017Evolution of grain boundary network topology in 316L austenitic stainless steel during powder hot isostatic pressingcitations
- 2017Development and Testing of an Additively Manufactured Monolithic Catalyst Bed for HTP Thruster Applicationscitations
- 2016Effect of casting practice on the reliability of Al cast alloyscitations
- 2016Adding functionality with additive manufacturing : fabrication of titanium-based antibiotic eluting implantscitations
- 2016Selective Laser Melting of TiNi Auxetic Structures
- 2016The development of TiNi-based negative Poisson's ratio structure using selective laser meltingcitations
- 2015Influence of processing conditions on strut structure and compressive properties of cellular lattice structures fabricated by selective laser meltingcitations
- 2015In-situ shelling via selective laser melting: modelling and microstructural characterisationcitations
Places of action
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article
Adding functionality with additive manufacturing : fabrication of titanium-based antibiotic eluting implants
Abstract
Additive manufacturing technologies have been utilised in healthcare to create patient-specific implants. This study demonstrates the potential to add new implant functionality by further exploiting the design flexibility of these technologies. Selective laser melting was used to manufacture titanium-based (Ti-6Al-4V) implants containing a reservoir. Pore channels, connecting the implant surface to the reservoir, were incorporated to facilitate antibiotic delivery. An injectable brushite, calcium phosphate cement, was formulated as a carrier vehicle for gentamicin. Incorporation of the antibiotic significantly (p=0.01) improved the compressive strength (5.8±0.7MPa) of the cement compared to non-antibiotic samples. The controlled release of gentamicin sulphate from the calcium phosphate cement injected into the implant reservoir was demonstrated in short term elution studies using ultraviolet-visible spectroscopy. Orientation of the implant pore channels were shown, using micro-computed tomography, to impact design reproducibility and the back-pressure generated during cement injection which ultimately altered porosity. The amount of antibiotic released from all implant designs over a 6hour period (<28% of the total amount) were found to exceed the minimum inhibitory concentrations of Staphylococcus aureus (16μg/mL) and Staphylococcus epidermidis (1μg/mL); two bacterial species commonly associated with periprosthetic infections. Antibacterial efficacy was confirmed against both bacterial cultures using an agar diffusion assay. Interestingly, pore channel orientation was shown to influence the directionality of inhibition zones. Promisingly, this work demonstrates the potential to additively manufacture a titanium-based antibiotic eluting implant, which is an attractive alternative to current treatment strategies of periprosthetic infections.