| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Neves, N.
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (10/10 displayed)
- 2024A facile strategy for tuning the density of surface-grafted biomolecules for melt extrusion-based additive manufacturing applicationscitations
- 2022Study of the immunologic response of marine-derived collagen and gelatin extracts for tissue engineering applicationscitations
- 2016Strontium-rich injectable hybrid system for bone regenerationcitations
- 2016Final Comments and Remarks
- 2011Design of nano- and microfiber combined scaffolds by electrospinning of collagen onto starch-based fiber meshes: A man-made equivalent of natural extracellular matrixcitations
- 2011Optimized electro- and wet-spinning techniques for the production of polymeric fibrous scaffolds loaded with bisphosphonate and hydroxyapatitecitations
- 20112D BI-LAYER SCAFFOLDS OF POLYCAPROLACTONE AND CHITOSAN beta-GLYCEROL-BASED FILM FOR BLOOD VESSEL CONSTRUCTS
- 2011Micro- and Nanotechnology in Tissue Engineeringcitations
- 2010High nonlinear optical anisotropy of urea nanofiberscitations
- 2008Co-culture of endothelial and smooth muscle cells for the development of blood vessel constructs
Places of action
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article
Strontium-rich injectable hybrid system for bone regeneration
Abstract
Current challenges in the development of scaffolds for bone regeneration include the engineering of materials that can withstand normal dynamic physiological mechanical stresses exerted on the bone and provide a matrix capable of supporting cell migration and tissue ingrowth. The objective of the present work was to develop and characterize a hybrid polymer-ceramic injectable system that consists of an alginate matrix crosslinked in situ in the presence of strontium (Sr), incorporating a ceramic reinforcement in the form of Sr-rich microspheres. The incorporation of Sr in the microspheres and in the vehicle relies on the growing evidence that Sr has beneficial effects in bone remodeling and in the treatment of osteopenic disorders and osteoporosis. Sr-rich porous hydroxyapatite microspheres with a uniform size and a mean diameter of 555 pm were prepared, and their compression strength and friability tested. A 3.5% (w/v) ultrapure sodium alginate solution was used as the vehicle and its in situ gelation was promoted by the addition of calcium (Ca) or Sr carbonate and Glucone-delta-lactone. Gelation times varied with temperature and crosslinking agent, being slower for Sr than for Ca, but adequate for injection in both cases. Injectability was evaluated using a device employed in vertebroplasty surgical procedures, coupled to a texture analyzer in compression mode. Compositions with 35% w of microspheres presented the best compromise between injectability and compression strength of the system, the force required to extrude it being lower than 100 N. Micro a analysis revealed a homogeneous distribution of the microspheres inside the vehicle, and a mean inter-microspheres space of 220 pm. DMA results showed that elastic behavior of the hybrid is dominant over the viscous one and that the higher storage modulus was obtained for the 3.5%Alg-35%Sr-HAp-Sr formulation.