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Naji, M. |
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Motta, Antonella |
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Aletan, Dirar |
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Mohamed, Tarek |
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Ertürk, Emre |
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Taccardi, Nicola |
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Kononenko, Denys |
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Petrov, R. H. | Madrid |
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Alshaaer, Mazen | Brussels |
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Bih, L. |
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Casati, R. |
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Muller, Hermance |
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Kočí, Jan | Prague |
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Šuljagić, Marija |
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Kalteremidou, Kalliopi-Artemi | Brussels |
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Azam, Siraj |
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Ospanova, Alyiya |
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Blanpain, Bart |
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Ali, M. A. |
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Popa, V. |
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Rančić, M. |
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Ollier, Nadège |
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Azevedo, Nuno Monteiro |
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Landes, Michael |
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Rignanese, Gian-Marco |
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Duarte, Ana Rita C.
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (69/69 displayed)
- 2024Assessment of oxidative stress biomarkers in Palaemon varians exposed to deep eutectic systems
- 2023Using Natural Deep Eutectic Systems as Alternative Media for Ocular Applicationscitations
- 2023Alginate–Chitosan Membranes for the Encapsulation of Lavender Essential Oil and Development of Biomedical Applications Related to Wound Healingcitations
- 2023Menthol-based deep eutectic systems as antimicrobial and anti-inflammatory agents for wound healingcitations
- 2023Hydrophobic DES Based on Menthol and Natural Organic Acids for Use in Antifouling Marine Coatingscitations
- 2023Uncovering biodegradability and biocompatibility of betaine-based deep eutectic systemscitations
- 2023Insights into therapeutic liquid mixtures and formulations towards tuberculosis therapycitations
- 2023Insights into therapeutic liquid mixtures and formulations towards tuberculosis therapycitations
- 2023Is it possible to correlate various physicochemical properties of Natural Deep eutectic systems in order to predict their behaviours as solvents?citations
- 2022Selective terpene based therapeutic deep eutectic systems against colorectal cancercitations
- 2022On the Not So Anomalous Water-induced Structural Transformations of Choline Chloride-Urea (Reline) Deep Eutectic Systemcitations
- 2022Fractionated extraction of polyphenols from mate tea leaves using a combination of hydrophobic/ hydrophilic NADEScitations
- 2022Fractionated extraction of polyphenols from mate tea leaves using a combination of hydrophobic/ hydrophilic NADEScitations
- 2022Assessing the Influence of Betaine-Based Natural Deep Eutectic Systems on Horseradish Peroxidasecitations
- 2022Assessment of deep eutectic solvents toxicity in zebrafish (Danio rerio)citations
- 2022Selective extraction and stabilization of bioactive compounds from rosemary leaves using a biphasic NADEScitations
- 2021Natural deep eutectic systems—A new era of cryopreservationcitations
- 2021Density of deep eutectic solvents ; The path forward cheminformatics-driven reliable predictions for mixturescitations
- 2021Effect of water on the structure and dynamics of choline chloride/glycerol eutectic systemscitations
- 2021Evaluation of Deep Eutectic Systems as an Alternative to Solvents in Painting Conservationcitations
- 2021Deep eutectic systems from betaine and polyols – Physicochemical and toxicological propertiescitations
- 2021Improved storage of influenza HA-VLPs using a trehalose-glycerol natural deep eutectic solvent systemcitations
- 2021Natural deep eutectic systems for nature-inspired cryopreservation of cellscitations
- 2021Unravelling the nature of citric acid:l-arginine:water mixtures ; The bifunctional role of watercitations
- 2021Low-Phytotoxic Deep Eutectic Systems as Alternative Extraction Media for the Recovery of Chitin from Brown Crab Shellscitations
- 2021Low-Phytotoxic Deep Eutectic Systems as Alternative Extraction Media for the Recovery of Chitin from Brown Crab Shellscitations
- 2021Influence of natural deep eutectic systems in water thermal behavior and their applications in cryopreservationcitations
- 2021A look on target-specificity of eutectic systems based on natural bioactive compoundscitations
- 2021Density of deep eutectic solventscitations
- 2020Optimal design of thedes based on perillyl alcohol and ibuprofencitations
- 2020Design and processing of drug delivery formulations of therapeutic deep eutectic systems for tuberculosiscitations
- 2020Collagen from Atlantic cod (Gadus morhua) skins extracted using CO2 acidified water with potential application in healthcarecitations
- 2020Terpene-Based Natural Deep Eutectic Systems as Efficient Solvents to Recover Astaxanthin from Brown Crab Shell Residuescitations
- 2020Advancing spinal fusion: Interbody stabilization by in situ foaming of a chemically modified polycaprolactonecitations
- 2019Unveil the Anticancer Potential of Limomene Based Therapeutic Deep Eutectic Solventscitations
- 2019Therapeutic Role of Deep Eutectic Solvents Based on Menthol and Saturated Fatty Acids on Wound Healingcitations
- 2019Properties of therapeutic deep eutectic solvents of L-arginine and ethambutol for tuberculosis treatmentcitations
- 2019A closer look in the antimicrobial properties of deep eutectic solvents based on fatty acidscitations
- 2018Synthesis and Physical and Thermodynamic Properties of Lactic Acid and Malic Acid-Based Natural Deep Eutectic Solventscitations
- 2018Chitin/Chitosan Based Aerogelscitations
- 2018Subcritical carbon dioxide foaming of polycaprolactone for bone tissue regenerationcitations
- 2018Natural deep eutectic systems as alternative nontoxic cryoprotective agentscitations
- 2018Chitin/chitosan based aerogels: processing and morphologycitations
- 2017Production of Electrospun Fast-Dissolving Drug Delivery Systems with Therapeutic Eutectic Systems Encapsulated in Gelatincitations
- 2017Biomaterials and bioactive agents in spinal fusioncitations
- 2017From honeycomb- to microsphere-patterned surfaces of poly(lactic acid) and a starch-poly(lactic acid) blend via the breath figure methodcitations
- 2017A comparison between pure active pharmaceutical ingredients and therapeutic deep eutectic solventscitations
- 2017Green solvents for enhanced impregnation processes in biomedicinecitations
- 2017Production of electrospun fast-dissolving drug delivery systems with therapeutic eutectic systems encapsulated in gelatincitations
- 2016In vitro bioactivity studies of ceramic structures isolated from marine spongescitations
- 2016Solubility and Permeability Enhancement of active compounds: Therapeutic Deep Eutectic Systems as New Vehicles for Drug Deliverycitations
- 2016Dissolution enhancement of active pharmaceutical ingredients by therapeutic deep eutectic systemscitations
- 2016Preparation of β-glucan scaffolds by hydrogel foaming with supercritical CO2
- 2015Design of controlled release systems for THEDES - Therapeutic deep eutectic solvents, using supercritical fluid technologycitations
- 2015The intersection between chemical and biomedical engineering: green technologies towards the development of enhanced biomaterialscitations
- 2015Ketoprofen-eluting biodegradable ureteral stents by CO2 impregnationcitations
- 2015Design of controlled release systems for THEDES - therapeutic deep eutectic solvents, using supercritical fluid technologycitations
- 2015Coupling Thedes - Therapeutic Deep Eutectic Solvents And Supercritical Fluid Technology for the Development of Controlled Delivery Systemscitations
- 2014Surface modification of silica-based marine sponge bioceramics induce hydroxyapatite formationcitations
- 2014Nanostructured hollow tubes based on chitosan and alginate multilayerscitations
- 2014Bioactive ceramics for tissue engineering and regenerative medicine derived from marine sponges
- 2013Alternative methodology for chitin-hydroxyapatite composites using ionic liquids and supercritical fluid technologycitations
- 2013Alternative methodology for chitin/hydroxyapatite composites using ionic liquids and supercritical fluid technologycitations
- 2013Nanostructured hollow tubes based on chitosan and alginate multilayers
- 2013Marine sponges : a new source of bioactive ceramics for tissue engineering and regenerative medicine applicationscitations
- 2013Unleashing the potential of supercritical fluids for polymer processing in tissue engineering and regenerative medicinecitations
- 2012PDLLA enriched with ulvan particles as a novel 3D porous scaffold targeted for bone engineeringcitations
- 2009Applications of supercritical expansion processes for particle formation
- 2009Processing of novel bioactive polymeric matrixes for tissue engineering using supercritical fluid technologycitations
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article
Processing of novel bioactive polymeric matrixes for tissue engineering using supercritical fluid technology
Abstract
<p>The aim of this study was to develop a new process for the production of bioactive 3D scaffolds using a clean and environmentally friendly technology. The possibility of preparing composite scaffolds of Bioglass<sup>®</sup> and a polymeric blend of starch and poly(l-lactic acid) (SPLA50) was evaluated. Supercritical phase-inversion technique was used to prepare inorganic particles loaded starch-based porous composite matrixes in a one-step process for bone tissue engineering purposes. Due to their osteoconductive properties some glasses and ceramics are interesting materials to be used for bone tissue engineering purposes; however their poor mechanical properties create the need of a polymeric support where the inorganic fraction can be dispersed. Samples impregnated with different concentrations of Bioglass<sup>®</sup> (10 and 15% wt/wt polymer) were prepared at 200 bar and 55 °C. The presence of Bioglass<sup>®</sup> did not affect the porosity or interconnectivity of the polymeric matrixes. Dynamic mechanical analysis has proven that the modulus of the SPLA50 scaffolds increases when glass particles are impregnated within the matrix. In vitro bioactivity studies were carried out using simulated body fluid and the results show that a calcium-phosphate layer started to be formed after only 1 day of immersion. Chemical analysis of the apatite layer formed on the surface of the scaffold was performed by different techniques, namely EDS and FTIR spectroscopy and X-ray diffraction (XRD). The ion concentration in the simulated body fluid was also carried out by ICP analysis. Results suggest that a bone-like apatite layer was formed. This study reports the feasibility of using supercritical fluid technology to process, in one step, a porous matrix loaded with a bioactive material for tissue engineering purposes.</p>