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Naji, M. |
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Motta, Antonella |
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Aletan, Dirar |
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Mohamed, Tarek |
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Ertürk, Emre |
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Taccardi, Nicola |
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Kononenko, Denys |
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Petrov, R. H. | Madrid |
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Alshaaer, Mazen | Brussels |
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Bih, L. |
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Casati, R. |
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Muller, Hermance |
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Kočí, Jan | Prague |
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Šuljagić, Marija |
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Kalteremidou, Kalliopi-Artemi | Brussels |
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Azam, Siraj |
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Ospanova, Alyiya |
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Blanpain, Bart |
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Ali, M. A. |
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Popa, V. |
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Rančić, M. |
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Ollier, Nadège |
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Azevedo, Nuno Monteiro |
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Landes, Michael |
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Rignanese, Gian-Marco |
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Glückstad, Jesper
University of Southern Denmark
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (23/23 displayed)
- 2022Light robotics
- 2022Light robotics:new micro-drones powered by light
- 2019Optimization of 3D-printed microstructures for investigating the properties of the mucus biobarriercitations
- 2018Light Robotics for Nanomedicine
- 2018Light Robotics – a growing toolbox for biomedical research
- 2018Optically fabricated and controlled microtool as a mobile heat source in microfluidics
- 2016Light‐driven Nano‐robotics - Invited Plenary Presentation, IEEE NANO 2016
- 2016Light‐driven Nano‐robotics - Invited Plenary Presentation, IEEE NANO 2016.
- 2013Structure-mediated nanoscopy
- 2013New two-photon based nanoscopic modalities and optogenetics
- 2013A new nano-biophotonics toolbox
- 2012Laser trapping and spatial light modulators
- 2012Towards Light‐guided Micro‐robotics
- 2012Wave-guided optical waveguidescitations
- 2012Micromanipulation and microfabrication for optical microrobotics
- 2012Optical Robotics in Mesoscopia
- 2012Light-driven nano-robotics for sub-diffraction probing and sensing
- 2012Mobile Waveguides: Freestanding Waveguides Steered by Light
- 2011Functionalized 2PP structures for the BioPhotonics Workstationcitations
- 2011Experimental demonstration of Generalized Phase Contrast based Gaussian beam-shapercitations
- 2009Optically controlled three-dimensional assembly of microfabricated building blocks
- 2009Optical microassembly platform for constructing reconfigurable microenvironment for biomedical studiescitations
- 2007Vision feedback driven automated assembly of photopolymerized structures by parallel optical trapping and manipulation
Places of action
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article
Optimization of 3D-printed microstructures for investigating the properties of the mucus biobarrier
Abstract
In order to overcome the mucus biobarrier for drug delivery purposes, a better understanding of the interactions between mucus and the drug carrier is needed. We propose optical catapulting of 3D-printed microstructures with tailored shape and surface chemistry as a means to study the interaction filtering properties of a model mucus biobarrier in dynamic conditions. Using twophoton polymerization, we fabricate microstructures with a resolution of approximately 200 nm. We introduce amino functional groups on the surface of the IP-L 780-derived polymer in a single step process via UV-assisted functionalization with an anthraquinone amine photolinker. Our optical catapulting system relies on Generalized Phase Contrast for beam shaping and it allows us to manipulate microstructures over a distance of 250 µm, similar to the mucus layer thickness in the upper part of the lower human intestine. This work is part of an ongoing endeavor to establish Light Robotics as a valuable toolbox for biomedical research.