| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Schnabelrauch, Matthias
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (6/6 displayed)
- 2023Rational engineering of glycosaminoglycan-based Dickkopf-1 scavengers to improve bone regenerationcitations
- 2021Artificial Extracellular Matrices Containing Bioactive Glass Nanoparticles Promote Osteogenic Differentiation in Human Mesenchymal Stem Cellscitations
- 2020The influence of different artificial extracellular matrix implant coatings on the regeneration of a critical size femur defect in ratscitations
- 2016Development of novel electrospun dual-drug fiber mats loaded with a combination of ampicillin and metronidazolecitations
- 2013Surface microstructuring and protein patterning using hyaluronan derivativescitations
- 2012Release of metronidazole from electrospun poly(l-lactide-co-d/l-lactide) fibers for local periodontitis treatmentcitations
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article
Surface microstructuring and protein patterning using hyaluronan derivatives
Abstract
Natural polymers, such as hyaluronan, are considered as good candidates to substitute synthetic materials in many biological applications due to their intrinsic biocompatibility for in vitro and living cell experiments. This work describes surface modifications performed over modified hyaluronan derivatives which could help to understand the physical and biochemical cues on the cell-behaviour. A photocrosslinkable methacrylated hyaluronan was microstructured using soft lithography techniques to obtain a microenvironment suitable for cell-behaviour experiments, which might mimic the extra-cellular matrix. In addition, sulphated and non-sulphated oxidized hyaluronan were immobilized on bare substrates and micrometric features of cell adhesive and non-adhesive proteins were patterned by microcontact printing on top of them. The obtained structures were characterized by optical microscopy, profilometry and atomic force microscopy. The stability of structures was tested by immersion in physiological salt solutions. The observed results prove the suitability of the materials and protocols described. ; This work was supported and carried out under the scope of the European Project Find and Bind (NMP4-SL-2009-229292).