| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Isaksson, Hanna
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (17/17 displayed)
- 2024Impact of storage time prior to cryopreservation on mechanical properties of aortic homograftscitations
- 2022Crack propagation in articular cartilage under cyclic loading using cohesive finite element modelingcitations
- 2022Fracture behavior of a composite of bone and calcium sulfate/hydroxyapatitecitations
- 2022Fracture behavior of a composite of bone and calcium sulfate/hydroxyapatitecitations
- 2021Dual modality neutron and x-ray tomography for enhanced image analysis of the bone-metal interfacecitations
- 2021Dual modality neutron and x-ray tomography for enhanced image analysis of the bone-metal interfacecitations
- 2020Spatio-temporal evolution of hydroxyapatite crystal thickness at the bone-implant interfacecitations
- 2020Bone Damage Evolution Around Integrated Metal Screws Using X-Ray Tomographycitations
- 2020Comparison of small‐angle neutron and X‐ray scattering for studying cortical bone nanostructurecitations
- 2020The influence of microstructure on crack propagation in cortical bone at the mesoscalecitations
- 2019An interface damage model that captures crack propagation at the microscale in cortical bone using XFEMcitations
- 2019Crack propagation in cortical bone is affected by the characteristics of the cement line : a parameter study using an XFEM interface damage modelcitations
- 2019Fracture strength of the proximal femur injected with a calcium sulfate/hydroxyapatite bone substitutecitations
- 2017Neutron tomographic imaging of bone-implant interfacecitations
- 2016Differences in acoustic impedance of fresh and embedded human trabecular bone samples - scanning acoustic microscopy and numerical evaluationcitations
- 2016Bone mineral crystal size and organization vary across mature rat bone cortexcitations
- 2016How accurately can subject-specific finite element models predict strains and strength of human femora? Investigation using full-field measurementscitations
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article
Bone mineral crystal size and organization vary across mature rat bone cortex
Abstract
<p>The macro- and micro-features of bone can be assessed by using imaging methods. However, nano- and molecular features require more detailed characterization, such as use of e.g., vibrational spectroscopy and X-ray scattering. Nano- and molecular features also affect the mechanical competence of bone tissue. The aim of the present study was to reveal the effects of mineralization and its alterations on the mineral crystal scale, by investigating the spatial variation of molecular composition and mineral crystal structure across the cross-section of femur diaphyses in young rats, and healthy and osteoporotic mature rats (N = 5). Fourier transform infrared spectroscopy and scanning small- and wide-angle X-ray scattering (SAXS/WAXS) techniques with high spatial resolution were used at identical locations over the whole cross-section. This allowed quantification of point-by-point information about the spatial distribution of mineral crystal volume. All measured parameters (crystal dimensions, degree of orientation and predominant orientation) varied across the cortex. Specifically, the crystal dimensions were lower in the central cortex than in the endosteal and periosteal regions. Mineral crystal orientation followed the cortical circumference in the periosteal and endosteal regions, but was less well-oriented in the central regions. Central cortex is formed rapidly during development through endochondral ossification. Since rats possess no osteonal remodeling, this bone remains (until old age). Significant linear correlations were observed between the dimensional and organizational parameters, e.g., between crystal length and degree of orientation (R<sup>2</sup> = 0.83, p < 0.001). Application of SAXS/WAXS provides valuable information on bone nanostructure and its constituents, effects of diseases and, prospectively, mechanical competence.</p>