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Naji, M. |
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Motta, Antonella |
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Aletan, Dirar |
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Mohamed, Tarek |
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Ertürk, Emre |
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Taccardi, Nicola |
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Kononenko, Denys |
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Petrov, R. H. | Madrid |
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Alshaaer, Mazen | Brussels |
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Bih, L. |
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Casati, R. |
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Muller, Hermance |
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Kočí, Jan | Prague |
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Šuljagić, Marija |
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Kalteremidou, Kalliopi-Artemi | Brussels |
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Azam, Siraj |
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Ospanova, Alyiya |
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Blanpain, Bart |
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Ali, M. A. |
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Popa, V. |
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Rančić, M. |
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Ollier, Nadège |
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Azevedo, Nuno Monteiro |
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Landes, Michael |
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Rignanese, Gian-Marco |
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Mundlos, S.
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (10/10 displayed)
- 2015Long bone maturation is driven by pore closing: A quantitative tomography investigation of structural formation in young C57BL/6 micecitations
- 2011THE ROLE OF OSTEOCYTES IN THE SKELETAL PATHOLOGY OF NEUROFIBROMATOSIS TYPE I (NF1)
- 2011Fetal and postnatal mouse bone tissue contains more calcium than is present in hydroxyapatitecitations
- 2011The organization of the osteocyte network mirrors the extracellular matrix orientation in bonecitations
- 2009Mineral deposition and growth during embryonal bone development in mice
- 2008Tibia and humerus bowing in a mouse model for neurofibromatosis type 1
- 2007Multiple roles for neurofibromin in skeletal development and growthcitations
- 2007Effect of bisphosphonate intake on the development of an osteonecrosis of the jaw
- 2007Osteonecrosis of the jaw under biphosphonate therapy - A German register for patients with osteonecrosis of the jaw
- 2007Osteonecrosis of jaw under bisphosphonate therapy: Patient profile and risk assessment
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article
The organization of the osteocyte network mirrors the extracellular matrix orientation in bone
Abstract
Bone is a dynamic tissue that is continually undergoing a process of remodeling - an effect due to the interplay between bone resorption by osteoclasts and bone formation by osteoblasts. When new bone is deposited, some of the osteoblasts are embedded in the mineralizing collagen matrix and differentiate to osteocytes, forming a dense network throughout the whole bone tissue. Here, we investigate the extent to which the organization of the osteocyte network controls the collagen matrix arrangement found in various bone tissues. Several tissue types from equine, ovine and murine bone have been examined using confocal laser scanning microscopy as well as polarized light microscopy and back-scattered electron imaging. From comparing the spatial arrangements of unorganized and organized bone, we propose that the formation of a highly oriented collagen matrix requires an alignment of osteoblasts whereby a substrate layer provides a surface such that osteoblasts can align and, collectively, build new matrix. Without such a substrate, osteoblasts act isolated and only form matrices without long range order. Hence, we conclude that osteoblasts synthesize and utilize scaffold-like primary tissue as a guide for the deposition of highly ordered and mechanically competent bone tissue by a collective action of many cells.