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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Esteves Da Silva, Jcge
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (18/18 displayed)
- 2020At-line monitoring of salification process of the antiretroviral lamivudine-saccharinate salt using FT-MIR spectroscopy with multivariate curve resolutioncitations
- 2019At-line green synthesis monitoring of new pharmaceutical co-crystals lamivudine:theophylline polymorph I and II, quantification of polymorph I among its APIs using FT-IR spectroscopy and MCR-ALScitations
- 2016Characterization of cellulose membranes modified with luminescent silicon quantum dots nanoparticlescitations
- 2014NO Fluorescence Quantification by Chitosan CdSe Quantum Dots Nanocompositescitations
- 2014Fingerprint detection and using intercalated CdSe nanoparticles on non-porous surfacescitations
- 2013Solid luminescent CdSe-thiolated porous phosphate heterostructures. Application in fingermark detection in different surfacescitations
- 2013Inclusion of thiol DAB dendrimer/CdSe quantum dots based in a membrane structure: Surface and bulk membrane modificationcitations
- 2013Coal Rank Increase and Aerial Oxidation by a Combination of Fourier Transform Infrared Spectroscopy with Multivariate Analysiscitations
- 2012Thiolated DAB dendrimer/ZnSe nanoparticles for C-reactive protein recognition in human serumcitations
- 2012Thiolated DAB dendrimers and CdSe quantum dots nanocomposites for Cd(II) or Pb(II) sensingcitations
- 2011CdS nanocomposites assembled in porous phosphate heterostructures for fingerprint detectioncitations
- 2011Chemometric Analysis of Excitation Emission Matrices of Fluorescent Nanocompositescitations
- 2011Analytical and bioanalytical applications of carbon dotscitations
- 2011Hybrid porous phosphate heterostructures as adsorbents of Hg(II) and Ni(II) from industrial sewagecitations
- 2011CdSe quantum dots capped PAMAM dendrimer nanocomposites for sensing nitroaromatic compoundscitations
- 2010Fluorescent Properties of a Hybrid Cadmium Sulfide-Dendrimer Nanocomposite and its Quenching with Nitromethanecitations
- 2010Porous phosphate heterostructures containing CdS quantum dots: assembly, characterization and photoluminescencecitations
- 2009Mercury(II) sensing based on the quenching of fluorescence of CdS-dendrimer nanocompositescitations
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article
At-line green synthesis monitoring of new pharmaceutical co-crystals lamivudine:theophylline polymorph I and II, quantification of polymorph I among its APIs using FT-IR spectroscopy and MCR-ALS
Abstract
This paper, reports for the first time the green synthesis of the polymorphs I and II of new pharmaceutical co-crystals lamivudine:theophylline in solid-phase, through the mixture between lamivudine and theophylline (both active pharmaceutical ingredients-APIs) in the proportion of 1:1 by neat grinding and liquid assisted grinding (10 mu L ethanol). Fourier transform-infrared (FT-IR) spectroscopy and multivariate curve resolution with alternating least-squares (MCR-ALS) were employed as non-invasive analytical methodology for the at-line green synthesis monitoring of the novels lamivudine:theophylline co-crystals. By MCR-ALS it was possible to identify each component present in a complex matrix, with strong spectral overlapping, containing lamivudine, theophylline, and the novel lamivudine:theophylline co-crystal with high confidence based on the comparison of the pure and recovered spectral and concentration profiles. This model allowed to identify the end of the reaction and understand the mechanism involved in the synthesis through the identification of the intermediates present in the synthesis process. Also, MCR-ALS model estimated the concentration of co-crystal polymorph I with a root mean square error of prediction (RMSEP) and the percentage relative error of prediction (REP%) equal to 3.323 (w/w) and 9.9%, respectively. These were good results since the spectral profile of cocrystal and the physical mixture of its APIs present strong spectral overlapping in their spectral domain. Therefore, the quantification of the co-crystal between its APIs (lamivudine and theophylline) certified that the co-crystal as final product was obtained, collaborating with the results obtained by differential scanning calorimetry (DSC) and X-ray powder diffraction (XRPD).