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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Cox, Sophie C.
University of Birmingham
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (18/18 displayed)
- 2024A genetic algorithm optimization framework for the characterization of hyper-viscoelastic materials
- 2023Tailoring absorptivity of highly reflective Ag powders by pulsed-direct current magnetron sputtering for additive manufacturing processescitations
- 2023Tailoring absorptivity of highly reflective Ag powders by pulsed-direct current magnetron sputtering for additive manufacturing processescitations
- 2022Surface Free Energy Dominates the Biological Interactions of Postprocessed Additively Manufactured Ti-6Al-4Vcitations
- 2022Controlled Release of Epigenetically-Enhanced Extracellular Vesicles from a GelMA/Nanoclay Composite Hydrogel to Promote Bone Repaircitations
- 2022The influence of thermal oxidation on the microstructure, fatigue properties, tribological and in vitro behaviour of laser powder bed fusion manufactured Ti-34 Nb-13Ta-5Zr-0.2O alloycitations
- 2022Development, characterisation, and modelling of processability of nitinol stents using laser powder bed fusioncitations
- 2022Photocurable antimicrobial silk-based hydrogels for corneal repaircitations
- 2021Surface finish of additively manufactured metalscitations
- 2021Biofilm viability checkercitations
- 2020Optimizing the antimicrobial performance of metallic glass composites through surface texturingcitations
- 2020Selective laser melting of Ti-6Al-4V: the impact of post-processing on the tensile, fatigue and biological properties for medical implant applicationscitations
- 2020Selective laser melting of ti-6al-4vcitations
- 2019Dynamic viscoelastic characterisation of human osteochondral tissuecitations
- 2018Formulation and viscoelasticity of mineralised hydrogels for use in bone-cartilage interfacial reconstructioncitations
- 2018The role of subchondral bone, and its histomorphology, on the dynamic viscoelasticity of cartilage, bone and osteochondral corescitations
- 2018Tailoring selective laser melting process for titanium drug-delivering implants with releasing micro-channelscitations
- 2016Adding functionality with additive manufacturing : fabrication of titanium-based antibiotic eluting implantscitations
Places of action
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article
The role of subchondral bone, and its histomorphology, on the dynamic viscoelasticity of cartilage, bone and osteochondral cores
Abstract
Objective: Viscoelastic properties of articular cartilage have been characterised at physiological frequencies. However, studies investigating the interaction between cartilage and subchondral bone and the influence of underlying bone histomorphometry on the viscoelasticity of cartilage are lacking.<br/><br/>Method: Dynamic Mechanical Analysis (DMA) has been used to quantify the dynamic viscoelasticity of bovine tibial plateau osteochondral cores, over a frequency sweep from 1 to 88 Hz. Specimens (approximately aged between 18 and 30 months) were neither osteoarthritic nor otherwise compromised. A maximum nominal stress of 1.7 MPa was induced. Viscoelastic properties of cores have been compared with that of its components (cartilage and bone) in terms of the elastic and viscous components of both structural stiffness and material modulus. Micro-computed tomography scans were used to quantify the histomorphological properties of the subchondral bone.<br/><br/>Results: Opposing frequency-dependent loss stiffness, and modulus, trends were witnessed for osteochondral tissues: for cartilage it increased logarithmically (P < 0.05); for bone it decreased logarithmically (P < 0.05). The storage stiffness of osteochondral cores was logarithmically frequency-dependent (P < 0.05), however, the loss stiffness was typically frequency-independent (P > 0.05). A linear relationship between the subchondral bone plate (SBP) thickness and cartilage thickness (P < 0.001) was identified. Cartilage loss modulus was linearly correlated to bone mineral density (BMD) (P < 0.05) and bone volume (P < 0.05).<br/><br/>Conclusion: The relationship between the subchondral bone histomorphometry and cartilage viscoelasticity (namely loss modulus) and thickness, have implications for the initiation and progression of osteoarthritis (OA) through an altered ability of cartilage to dissipate energy.