| People | Locations | Statistics |
|---|---|---|
| Naji, M. |
| |
| Motta, Antonella |
| |
| Aletan, Dirar |
| |
| Mohamed, Tarek |
| |
| Ertürk, Emre |
| |
| Taccardi, Nicola |
| |
| Kononenko, Denys |
| |
| Petrov, R. H. | Madrid |
|
| Alshaaer, Mazen | Brussels |
|
| Bih, L. |
| |
| Casati, R. |
| |
| Muller, Hermance |
| |
| Kočí, Jan | Prague |
|
| Šuljagić, Marija |
| |
| Kalteremidou, Kalliopi-Artemi | Brussels |
|
| Azam, Siraj |
| |
| Ospanova, Alyiya |
| |
| Blanpain, Bart |
| |
| Ali, M. A. |
| |
| Popa, V. |
| |
| Rančić, M. |
| |
| Ollier, Nadège |
| |
| Azevedo, Nuno Monteiro |
| |
| Landes, Michael |
| |
| Rignanese, Gian-Marco |
|
Khademhosseini, Ali
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (12/12 displayed)
- 2023A handheld bioprinter for multi-material printing of complex constructscitations
- 2023Aerogel-Based Biomaterials for Biomedical Applications: From Fabrication Methods to Disease-Targeting Applicationscitations
- 2023Drug‐Eluting Shear‐Thinning Hydrogel for the Delivery of Chemo‐ and Immunotherapeutic Agents for the Treatment of Hepatocellular Carcinomacitations
- 2022Assessing the aneurysm occlusion efficacy of a shear-thinning biomaterial in a 3D-printed model.citations
- 2022Additively manufactured metallic biomaterialscitations
- 2021In situ 3D printing of implantable energy storage devicescitations
- 2019The future of layer-by-layer assembly: A tribute to ACS Nano associate editor Helmuth Möhwaldcitations
- 2019Biocompatible Carbon Nanotube-Based Hybrid Microfiber for Implantable Electrochemical Actuator and Flexible Electronic Applications.citations
- 2018Nanobead-on-string composites for tendon tissue engineeringcitations
- 2017Biodegradable elastic nanofibrous platforms with integrated flexible heaters for on-demand drug deliverycitations
- 2016Nanotechnology in textilescitations
- 2016Platinum nanopetal-based potassium sensors for acute cell death monitoringcitations
Places of action
| Organizations | Location | People |
|---|
article
Assessing the aneurysm occlusion efficacy of a shear-thinning biomaterial in a 3D-printed model.
Abstract
Metallic coil embolization is a common method for the endovascular treatment of visceral artery aneurysms (VAA) and visceral artery pseudoaneurysms (VAPA); however, this treatment is suboptimal due to the high cost of coils, incomplete volume occlusion, poor reendothelialization, aneurysm puncture, and coil migration. Several alternative treatment strategies are available, including stent flow diverters, glue embolics, gelfoam slurries, and vascular mesh plugs-each of which have their own disadvantages. Here, we investigated the in vitro capability of a shear-thinning biomaterial (STB), a nanocomposite hydrogel composed of gelatin and silicate nanoplatelets, for the minimally-invasive occlusion of simple necked aneurysm models. We demonstrated the injectability of STB through various clinical catheters, engineered an in vitro testing apparatus to independently manipulate aneurysm neck diameter, fluid flow rate, and flow waveform, and tested the stability of STB within the models under various conditions. Our experiments show that STB is able to withstand at least 1.89Pa of wall shear stress, as estimated by computational fluid dynamics. STB is also able to withstand up to 10mLs-1 pulsatile flow with a waveform mimicking blood flow in the human femoral artery and tolerate greater pressure changes than those in the human aorta. We ultimately found that our in vitro system was limited by supraphysiologic pressure changes caused by aneurysm models with low compliance.