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Naji, M. |
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Motta, Antonella |
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Aletan, Dirar |
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Mohamed, Tarek |
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Ertürk, Emre |
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Taccardi, Nicola |
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Kononenko, Denys |
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Petrov, R. H. | Madrid |
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Alshaaer, Mazen | Brussels |
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Bih, L. |
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Casati, R. |
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Muller, Hermance |
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Kočí, Jan | Prague |
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Šuljagić, Marija |
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Kalteremidou, Kalliopi-Artemi | Brussels |
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Azam, Siraj |
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Ospanova, Alyiya |
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Blanpain, Bart |
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Ali, M. A. |
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Popa, V. |
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Rančić, M. |
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Ollier, Nadège |
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Azevedo, Nuno Monteiro |
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Landes, Michael |
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Rignanese, Gian-Marco |
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Fratzl-Zelman, N.
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (31/31 displayed)
- 2019Cortical bone properties in the Brtl/+ mouse model of Osteogenesis imperfecta as evidenced by acoustic transmission microscopycitations
- 2014Pediatric reference Raman data for material characteristics of iliac trabecular bonecitations
- 2014Relationship of Bone Mineralization Density Distribution (BMDD) in Cortical and Cancellous Bone Within the Iliac Crest of Healthy Premenopausal Womencitations
- 2012Bone matrix mineralization in osteogenesis imperfecta type VI
- 2012Mineral particle size in children with dominant osteogenesis imperfecta is not associated with specific collagen mutation: A synchrotron X-ray scattering studycitations
- 2010Mineralization density distribution of postmenopausal osteoporotic bone is restored to normal after long-term alendronate treatment: qBEI and sSAXS data from the fracture intervention trial long-term extension (FLEX)citations
- 2010Bone material quality in transiliac bone biopsies of postmenopausal osteoporotic women after 3 years of strontium ranelate treatmentcitations
- 2009Combination of nanoindentation and quantitative backscattered electron imaging revealed altered bone material properties associated with femoral neck fragilitycitations
- 2009Evidence of genetic disorders which affect the primary mineralization process of bone matrix
- 2007Evidence that treatment with risedronate in women with postmenopausal osteoporosis affects bone mineralization and bone volumecitations
- 2007Mineralization status of bone matrix in postmenopausal women during a 10-year alendronate treatment period
- 2007Bone material characteristics in osteoporotic postmenopausal women after 3-year treatment with strontium ranelate
- 2006Pamidronate does not adversely affect bone intrinsic material properties in children with osteogenesis imperfectacitations
- 2006Femoral neck fragility is associated with altered bone collagen/mineral nanocomposite properties in osteoporotic women
- 2006Three-year strontium ranelate treatment in osteoporotic women preserves collagen quality in newly formed bone
- 2006Individual bone structural unit characteristics in osteoporotic postmenopausal women after 3-year treatment with strontium ranelate
- 2006Tissue and material characteristics in osteogenesis imperfecta type I: Quantitative versus qualitative collagen mutations
- 2005Biomimetic mineral-organic composite scaffolds with controlled internal architecturecitations
- 2005Towards bone replacement materials from calcium phosphates via rapid prototyping and ceramic gelcastingcitations
- 2005Combined treatment with PTH (1-34) and OPG increases bone volume and uniformity of mineralization in aged ovariectomized ratscitations
- 2004Pamidronate therapy in children with osteogenesis imperfecta: Effect on the bone material level
- 2004Intravenous pamidronate treatment in children with osteogenesis imperfecta increases cancellous bone volume but does not alter mineralization density of bone matrix
- 2004Decreased bone turnover and deterioration of bone structure in two cases of pycnodysostosiscitations
- 2003Cyclical pamidronate treatment does not affect bone mineralization density distribution in children suffering from osteogenesis imperfecta
- 2003Porous hydroxyapatite scaffolds constructed by microstereolithography are suitable substrates for osteoblasts
- 2003Increased uniformity in bone mineralization after combined treatment of PTH-(1-34) and OPG in osteopenic ovariectomized rats
- 2003Orientation of mineral crystallites and mineral density during skeletal development in mice deficient in tissue nonspecific alkaline phosphatasecitations
- 2003Treatment of osteopenic ovariectomized (OVX) rats with a combination of PTH-(1-34) and OPG leads to elevated bone volume and increased uniformity in bone mineralization
- 2003Mineralized microstructure of calcified avian tendons: A scanning small angle X-ray scattering studycitations
- 2002Osteoclastic dysfunction leads to impaired mechanical adaptation of bone structure in pycnodysostosis: Tiransilical biopsy study of two patients with defined mutations within the cathepsin K gene
- 2000A new stretching apparatus for applying anisotropic mechanical strain to bone cells in-vitrocitations
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article
Cortical bone properties in the Brtl/+ mouse model of Osteogenesis imperfecta as evidenced by acoustic transmission microscopy
Abstract
<p>Higher skeletal fragility has been established for the Brtl/+ mouse model of osteogenesis imperfecta at the whole bone level, but previous investigations of mechanical properties at the bone material level were inconclusive. Bone material was analyzed separately at endosteal (ER) and periosteal regions (PR) on transverse femoral midshaft sections for 2-month old mice (wild-type n = 6; Brtl/+ n = 6). Quantitative backscattered electron imaging revealed that the mass density computed from mineral density maps was higher in PR than in ER for both wild-type (+2.1%, p < 0.05) and Brtl/+ mice (+1.8%, p < 0.05). Electron induced X-ray fluorescence analysis indicated significantly lower atomic Ca/P ratios and higher Na/Ca, Mg/Ca and K/Ca ratios in PR bone compared to ER independently of genotype. Second harmonic generation microscopy indicated that the occurrence of periodically alternating collagen orientation in ER of Brtl/+ mice was strongly reduced compared to wild-type mice. Scanning acoustic microscopy in time of flight mode revealed that the sound velocity and Young's modulus (estimated based on sound velocity and mass density maps) were significantly greater in PR (respectively +6% and +15%) compared to ER in wild-type mice but not in Brtl/+ mice. ER sound velocity and Young's modulus were significantly increased in Brtl/+ mice (+9.4% and +22%, respectively) compared to wild-type mice. These data demonstrate that the Col1a1 G349C mutation in Brtl/+ mice affects the mechanical behavior of bone material predominantly in the endosteal region by altering the collagen orientation.</p>