| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Blunn, Gw
University of Portsmouth
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (21/21 displayed)
- 2023Accelerated Degradation of Poly-ε-caprolactone Composite Scaffolds for Large Bone Defectscitations
- 2022Design and in vivo testing of novel single-stage tendon graft using polyurethane nanocomposite polymer for tendon reconstructioncitations
- 2018Novel adaptive finite element algorithms to predict bone ingrowth in additive manufactured porous implantscitations
- 2018Novel adaptive finite element algorithms to predict bone ingrowth in additive manufactured porous implants.
- 2017Clinical cold welding of the modular total hip arthroplasty prosthesiscitations
- 2017Intrinsic osteoinductivity of porous titanium scaffold for bone tissue engineeringcitations
- 2017Fretting corrosion behavior of nitinol spinal rods in conjunction with titanium pedicle screwscitations
- 2016Corrosion at the head-neck interface of current designs of modular femoral componentscitations
- 2016Metal concentrations in the blood and tissues after implantation of titanium growth guidance sliding instrumentationcitations
- 2016Nanohydroxyapatite effect on the degradation, osteoconduction and mechanical properties of polymeric bone tissue engineered scaffoldscitations
- 2015The effect of frictional torque and bending moment on corrosion at the taper interfacecitations
- 2015Lessons from retrievalscitations
- 2015Analysis of retrieved growth guidance sliding LSZ-4D devices for early onset scoliosis and investigation of the use of nitinol rods for this systemcitations
- 2015Silicate-substituted calcium phosphate with enhanced strut porosity stimulates osteogenic differentiation of human mesenchymal stem cellscitations
- 2014Low dose of propranolol does not affect rat osteotomy healing and callus strengthcitations
- 2013Enhanced wear and corrosion in modular tapers in total hip replacement is associated with the contact area and surface topographycitations
- 2011Enhancing the soft tissue seal around intraosseous transcutaneous amputation prostheses using silanized fibronectin titanium alloycitations
- 2008Composite ceramic bone graft substitute in the treatment of locally aggressive benign bone tumours.citations
- 2006Porous Ti-6Al-4V bone replacement materials produced by Selective Laser Sintering (SLS)
- 2004The effect of diamond like carbon and hydroxyapatite coatings on soft tissue reactions to external fixation screws under load
- 2000Fractographic examination of racing greyhound central (navicular) tarsal bone failure surfaces using scanning electron microscopy
Places of action
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article
Novel adaptive finite element algorithms to predict bone ingrowth in additive manufactured porous implants
Abstract
Bone loss caused by stress shielding of metallic implants is a concern, as it can potentially lead to long-term implant failure. Surface coating and reducing structural stiffness of implants are two ways to improve bone ingrowth and osteointegration. Additive manufacturing, through selective laser sintering (SLS) or electron beam melting (EBM) of metallic alloys, can produce porous implants with bone ingrowth regions that enhance osteointegration and improve clinical outcomes. Histology of porous Ti6Al4V plugs of two pore sizes with and without electrochemically deposited hydroxyapatite coating, implanted in ovine condyles, showed that bone formation did not penetrate deep into the porous structure, whilst significantly increased bone growth along coated pore surfaces (osteointegration) was observed. Finite Element simulations, combining new algorithms to model bone ingrowth and the effect of surface modification on osteoconduction, were verified with the histology results. The results showed stress shielding of porous implants made from conventional titanium alloy due to material stiffness and implant geometry, limiting ingrowth and osteointegration. Simulations for reduced implant material stiffness predicted increased bone ingrowth. For low modulus Titanium-tantalum alloy (Ti-70%Ta), reduced stress shielding and enhanced bone ingrowth into the porous implant was found, leading to improved mechanical interlock. Algorithms predicted osteoconductive coating to promote both osteointegration and bone ingrowth into the inner pores when they were coated. These new Finite Element algorithms show that using implant materials with lower elastic modulus, osteoconductive coatings or improved implant design could lead to increased bone remodelling that optimises tissue regeneration, fulfilling the potential of enhanced porosity and complex implant designs made possible by additive layer manufacturing techniques.