| People | Locations | Statistics |
|---|---|---|
| Naji, M. |
| |
| Motta, Antonella |
| |
| Aletan, Dirar |
| |
| Mohamed, Tarek |
| |
| Ertürk, Emre |
| |
| Taccardi, Nicola |
| |
| Kononenko, Denys |
| |
| Petrov, R. H. | Madrid |
|
| Alshaaer, Mazen | Brussels |
|
| Bih, L. |
| |
| Casati, R. |
| |
| Muller, Hermance |
| |
| Kočí, Jan | Prague |
|
| Šuljagić, Marija |
| |
| Kalteremidou, Kalliopi-Artemi | Brussels |
|
| Azam, Siraj |
| |
| Ospanova, Alyiya |
| |
| Blanpain, Bart |
| |
| Ali, M. A. |
| |
| Popa, V. |
| |
| Rančić, M. |
| |
| Ollier, Nadège |
| |
| Azevedo, Nuno Monteiro |
| |
| Landes, Michael |
| |
| Rignanese, Gian-Marco |
|
Cox, Sophie C.
University of Birmingham
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (18/18 displayed)
- 2024A genetic algorithm optimization framework for the characterization of hyper-viscoelastic materials
- 2023Tailoring absorptivity of highly reflective Ag powders by pulsed-direct current magnetron sputtering for additive manufacturing processescitations
- 2023Tailoring absorptivity of highly reflective Ag powders by pulsed-direct current magnetron sputtering for additive manufacturing processescitations
- 2022Surface Free Energy Dominates the Biological Interactions of Postprocessed Additively Manufactured Ti-6Al-4Vcitations
- 2022Controlled Release of Epigenetically-Enhanced Extracellular Vesicles from a GelMA/Nanoclay Composite Hydrogel to Promote Bone Repaircitations
- 2022The influence of thermal oxidation on the microstructure, fatigue properties, tribological and in vitro behaviour of laser powder bed fusion manufactured Ti-34 Nb-13Ta-5Zr-0.2O alloycitations
- 2022Development, characterisation, and modelling of processability of nitinol stents using laser powder bed fusioncitations
- 2022Photocurable antimicrobial silk-based hydrogels for corneal repaircitations
- 2021Surface finish of additively manufactured metalscitations
- 2021Biofilm viability checkercitations
- 2020Optimizing the antimicrobial performance of metallic glass composites through surface texturingcitations
- 2020Selective laser melting of Ti-6Al-4V: the impact of post-processing on the tensile, fatigue and biological properties for medical implant applicationscitations
- 2020Selective laser melting of ti-6al-4vcitations
- 2019Dynamic viscoelastic characterisation of human osteochondral tissuecitations
- 2018Formulation and viscoelasticity of mineralised hydrogels for use in bone-cartilage interfacial reconstructioncitations
- 2018The role of subchondral bone, and its histomorphology, on the dynamic viscoelasticity of cartilage, bone and osteochondral corescitations
- 2018Tailoring selective laser melting process for titanium drug-delivering implants with releasing micro-channelscitations
- 2016Adding functionality with additive manufacturing : fabrication of titanium-based antibiotic eluting implantscitations
Places of action
| Organizations | Location | People |
|---|
article
Formulation and viscoelasticity of mineralised hydrogels for use in bone-cartilage interfacial reconstruction
Abstract
Articular cartilage is a viscoelastic tissue whose structural integrity is important in maintaining joint health. To restore the functionality of osteoarthritic joints it is vital that regenerative strategies mimic the dynamic loading response of cartilage and bone. Here, a rotating simplex model was employed to optimise the composition of agarose and gellan hydrogel constructs structured with hydroxyapatite (HA) with the aim of obtaining composites mechanically comparable to human cartilage in terms of their ability to dissipate energy. Addition of ceramic particles was found to reinforce both matrices up to a critical concentration (<3 w/v%). Beyond this, larger agglomerates were formed, as evidenced by micro computed tomography data, which acted as stress risers and reduced the ability of composites to dissipate energy demonstrated by a reduction in tan δ values. A maximum compressive modulus of 450.7±24.9 kPa was achieved with a composition of 5.8 w/v% agarose and 0.5 w/v% HA. Interestingly, when loaded dynamically (1 – 20 Hz) this optimised formulation did not exhibit the highest complex modulus instead a sample with a higher concentration of mineral was identified (5.8 w/v% agarose and 25 w/v% HA). Thus, demonstrating the importance of examining the mechanical behaviour of biomaterials under conditions representative of physiological environments. While the complex moduli of the optimised gellan (1.0±0.2 MPa at 1 Hz) and agarose (1.7±0.2 MPa at 1 Hz) constructs did not match the complex moduli of healthy human cartilage samples (26.3±6.5 MPa at 1 Hz), similar tan δ values were observed between 1 and 5 Hz. This is promising since these frequencies represent the typical heel strike time of the general population. In summary, this study demonstrates the importance of considering more than just the strength of biomaterials since tissues like cartilage play a more complex role.